mta1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description metastasis associated 1|This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 9112)
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Genes

36 genes co-occuring with the biological term mta1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
BRCA1 breast cancer 1, early onset
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
EIF5A2 eukaryotic translation initiation factor 5A2
ELAVL1 ELAV like RNA binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST4H4 histone cluster 4, H4
HSF1 heat shock transcription factor 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR125B1 microRNA 125b-1
MIR125B2 microRNA 125b-2
MIR661 microRNA 661
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOS2 nitric oxide synthase 2, inducible
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCNA proliferating cell nuclear antigen
RBBP4 retinoblastoma binding protein 4
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RNF144A ring finger protein 144A
SIX3 SIX homeobox 3
SMAD7 SMAD family member 7
TGFB1 transforming growth factor, beta 1
TP53 tumor protein p53
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C