mthfr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description methylenetetrahydrofolate reductase (NAD(P)H)|The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 4524)
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Genes

95 genes co-occuring with the biological term mthfr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRA2A adrenoceptor alpha 2A
AGTR1 angiotensin II receptor, type 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMH anti-Mullerian hormone
APOA5 apolipoprotein A-V
APOE apolipoprotein E
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CDA cytidine deaminase
CDKN2A cyclin-dependent kinase inhibitor 2A
CHDH choline dehydrogenase
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CSK c-src tyrosine kinase
CTCFL CCCTC-binding factor (zinc finger protein)-like
CYBA cytochrome b-245, alpha polypeptide
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAZL deleted in azoospermia-like
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHFR dihydrofolate reductase
DPYD dihydropyrimidine dehydrogenase
DRD3 dopamine receptor D3
ERCC1 excision repair cross-complementation group 1
ERCC5 excision repair cross-complementation group 5
ERN1 endoplasmic reticulum to nucleus signaling 1
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FGF5 fibroblast growth factor 5
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FTO fat mass and obesity associated
G6PD glucose-6-phosphate dehydrogenase
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HFE hemochromatosis
ICAM1 intercellular adhesion molecule 1
IGF2 insulin-like growth factor 2
IL4 interleukin 4
IL6 interleukin 6
IRF6 interferon regulatory factor 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JUN jun proto-oncogene
LDLR low density lipoprotein receptor
LOXL1 lysyl oxidase-like 1
LTA lymphotoxin alpha
MAOA monoamine oxidase A
MGMT O-6-methylguanine-DNA methyltransferase
MIR149 microRNA 149
MLH1 mutL homolog 1
MPO myeloperoxidase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PEMT phosphatidylethanolamine N-methyltransferase
PON1 paraoxonase 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFC1 replication factor C (activator 1) 1, 145kDa
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNRPN small nuclear ribonucleoprotein polypeptide N
STK39 serine threonine kinase 39
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCN2 transcobalamin II
TGFA transforming growth factor, alpha
TGFB3 transforming growth factor, beta 3
TH tyrosine hydroxylase
TP53 tumor protein p53
TPMT thiopurine S-methyltransferase
TYMS thymidylate synthetase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor