mtor Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description mechanistic target of rapamycin (serine/threonine kinase)|The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 2475)
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Genes

282 genes co-occuring with the biological term mtor in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACACA acetyl-CoA carboxylase alpha
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
AMBRA1 autophagy/beclin-1 regulator 1
APC adenomatous polyposis coli
AR androgen receptor
ATF4 activating transcription factor 4
ATG13 autophagy related 13
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C2ORF68 chromosome 2 open reading frame 68
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC28B coiled-coil domain containing 28B
CCND1 cyclin D1
CCNG2 cyclin G2
CCR7 chemokine (C-C motif) receptor 7
CD247 CD247 molecule
CDC42 cell division cycle 42
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN2 claudin 2
CRTC2 CREB regulated transcription coactivator 2
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CUL4B cullin 4B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DDIT4L DNA-damage-inducible transcript 4-like
DEK DEK proto-oncogene
DEPTOR DEP domain containing MTOR-interacting protein
DGKZ diacylglycerol kinase, zeta
EDN1 endothelin 1
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ENG endoglin
EPHB4 EPH receptor B4
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
F10 coagulation factor X
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FANCD2 Fanconi anemia, complementation group D2
FAS Fas cell surface death receptor
FASN fatty acid synthase
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP1A FK506 binding protein 1A, 12kDa
FKBP8 FK506 binding protein 8, 38kDa
FLCN folliculin
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FNIP1 folliculin interacting protein 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GABARAP GABA(A) receptor-associated protein
GATA1 GATA binding protein 1 (globin transcription factor 1)
GFAP glial fibrillary acidic protein
GHRL ghrelin/obestatin prepropeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GSK3B glycogen synthase kinase 3 beta
GSPT1 G1 to S phase transition 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSF1 heat shock transcription factor 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFN1@ interferon, type 1, cluster
IFNG interferon, gamma
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL12B interleukin 12B
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
ILK integrin-linked kinase
INS insulin
IPMK inositol polyphosphate multikinase
IQGAP1 IQ motif containing GTPase activating protein 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
JAG1 jagged 1
JUNB jun B proto-oncogene
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLK3 kallikrein-related peptidase 3
KLK4 kallikrein-related peptidase 4
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRAS Kirsten rat sarcoma viral oncogene homolog
LACRT lacritin
LEP leptin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAF1 MAF1 homolog (S. cerevisiae)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR100 microRNA 100
MIR101-1 microRNA 101-1
MIR144 microRNA 144
MIR148A microRNA 148a
MIR155 microRNA 155
MIR199A1 microRNA 199a-1
MIR199B microRNA 199b
MIR21 microRNA 21
MIR99A microRNA 99a
MIR99B microRNA 99b
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MLXIP MLX interacting protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSTN myostatin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOTCH2 notch 2
NOV nephroblastoma overexpressed
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUP153 nucleoporin 153kDa
NUP214 nucleoporin 214kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PARP1 poly (ADP-ribose) polymerase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFB platelet-derived growth factor beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIH1D1 PIH1 domain containing 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK2 polo-like kinase 2
PML promyelocytic leukemia
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP5C protein phosphatase 5, catalytic subunit
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRKCSH protein kinase C substrate 80K-H
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB4A RAB4A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1B RAP1B, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RET ret proto-oncogene
RHEB Ras homolog enriched in brain
RHEBL1 Ras homolog enriched in brain like 1
RHEBP1 Ras-homolog enriched in brain pseudogene 1
RHOA ras homolog family member A
RICTOR RPTOR independent companion of MTOR, complex 2
RIOK1 RIO kinase 1
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
SACK1D scaffolding CK1 anchoring protein D
SESN2 sestrin 2
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD1 SMAD family member 1
SMAD5 SMAD family member 5
SMAD9 SMAD family member 9
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMN1 survival of motor neuron 1, telomeric
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX2 SRY (sex determining region Y)-box 2
SPAG5 sperm associated antigen 5
SQSTM1 sequestosome 1
SRPK1 SRSF protein kinase 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STK4 serine/threonine kinase 4
TBCK TBC1 domain containing kinase
TBK1 TANK-binding kinase 1
TELO2 telomere maintenance 2
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
THPO thrombopoietin
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TP73 tumor protein p73
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TWIST2 twist family bHLH transcription factor 2
TXNIP thioredoxin interacting protein
UBR5 ubiquitin protein ligase E3 component n-recognin 5
ULK1 unc-51 like autophagy activating kinase 1
ULK2 unc-51 like autophagy activating kinase 2
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP9X ubiquitin specific peptidase 9, X-linked
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VTN vitronectin
YAP1 Yes-associated protein 1