mtor Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description mechanistic target of rapamycin (serine/threonine kinase)|The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 2475)
Similar Terms
Downloads & Tools

Genes

135 proteins co-occuring with the biological term mtor in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMBRA1 autophagy/beclin-1 regulator 1
AR androgen receptor
BAD BCL2-associated agonist of cell death
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BECN1 beclin 1, autophagy related
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREB1 cAMP responsive element binding protein 1
DAP death-associated protein
DEPTOR DEP domain containing MTOR-interacting protein
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF6 eukaryotic translation initiation factor 6
ELK1 ELK1, member of ETS oncogene family
ESR1 estrogen receptor 1
EZR ezrin
FASN fatty acid synthase
FBXW8 F-box and WD repeat domain containing 8
FLCN folliculin
FLNC filamin C, gamma
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GLI1 GLI family zinc finger 1
GRB10 growth factor receptor-bound protein 10
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GYS1 glycogen synthase 1 (muscle)
H2AFX H2A histone family, member X
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H3A histone cluster 1, H3a
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSF1 heat shock transcription factor 1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
JAK2 Janus kinase 2
JUN jun proto-oncogene
KRT17 keratin 17, type I
LIMK1 LIM domain kinase 1
LIPE lipase, hormone-sensitive
LPIN1 lipin 1
MAF1 MAF1 homolog (S. cerevisiae)
MAP4 microtubule-associated protein 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NDRG1 N-myc downstream regulated 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4D phosphodiesterase 4D, cAMP-specific
PDPK1 3-phosphoinositide dependent protein kinase 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PTEN phosphatase and tensin homolog
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHEB Ras homolog enriched in brain
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMAD1 SMAD family member 1
SMAD5 SMAD family member 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPK1 SRSF protein kinase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK11 serine/threonine kinase 11
STK4 serine/threonine kinase 4
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D4 TBC1 domain family, member 4
TELO2 telomere maintenance 2
TERT telomerase reverse transcriptase
TFEB transcription factor EB
TP53 tumor protein p53
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTI1 TELO2 interacting protein 1
ULK1 unc-51 like autophagy activating kinase 1
YY1 YY1 transcription factor