muc1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description mucin 1, cell surface associated|This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 4582)
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Genes

108 genes co-occuring with the biological term muc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACPP acid phosphatase, prostate
ADAM17 ADAM metallopeptidase domain 17
AFP alpha-fetoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
CALR calreticulin
CAMLG calcium modulating ligand
CAMP cathelicidin antimicrobial peptide
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCND1 cyclin D1
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDX2 caudal type homeobox 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSK c-src tyrosine kinase
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL8 chemokine (C-X-C motif) ligand 8
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EGFR epidermal growth factor receptor
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGFR3 fibroblast growth factor receptor 3
FOXO3 forkhead box O3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA3 GATA binding protein 3
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICAM1 intercellular adhesion molecule 1
IGHA1 immunoglobulin heavy constant alpha 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL6 interleukin 6
INHBA inhibin, beta A
JUP junction plakoglobin
KLK3 kallikrein-related peptidase 3
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT5 keratin 5, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAG myelin associated glycoprotein
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MET MET proto-oncogene, receptor tyrosine kinase
MIR141 microRNA 141
MIR145 microRNA 145
MIR200C microRNA 200c
MIR424 microRNA 424
MIR551B microRNA 551b
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MSLN mesothelin
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MUC8 mucin 8
MYD88 myeloid differentiation primary response 88
NKX2-1 NK2 homeobox 1
NOS2 nitric oxide synthase 2, inducible
NRG1 neuregulin 1
PAEP progestagen-associated endometrial protein
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCE1 phospholipase C, epsilon 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PSCA prostate stem cell antigen
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
S100A7 S100 calcium binding protein A7
SELE selectin E
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI1 snail family zinc finger 1
SPRR2A small proline-rich protein 2A
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TRIM29 tripartite motif containing 29
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2