myc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description v-myc avian myelocytomatosis viral oncogene homolog|The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4609)
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Genes

218 genes co-occuring with the biological term myc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ATAD2 ATPase family, AAA domain containing 2
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AXIN1 axin 1
AXIN2 axin 2
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP7 bone morphogenetic protein 7
BRCA1 breast cancer 1, early onset
BRD4 bromodomain containing 4
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCAT1 colon cancer associated transcript 1 (non-protein coding)
CCNB1 cyclin B1
CCND1 cyclin D1
CCNT1 cyclin T1
CD33 CD33 molecule
CD34 CD34 molecule
CDCA7 cell division cycle associated 7
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CREB1 cAMP responsive element binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL7 cullin 7
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DDHD2 DDHD domain containing 2
DLX5 distal-less homeobox 5
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
EGFR epidermal growth factor receptor
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPC1 enhancer of polycomb homolog 1 (Drosophila)
EPC2 enhancer of polycomb homolog 2 (Drosophila)
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO28 F-box protein 28
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FHIT fragile histidine triad
FLT4 fms-related tyrosine kinase 4
FOXO3 forkhead box O3
GATA4 GATA binding protein 4
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSK3B glycogen synthase kinase 3 beta
HAVCR2 hepatitis A virus cellular receptor 2
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HES1 hes family bHLH transcription factor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST3H3 histone cluster 3, H3
HLX H2.0-like homeobox
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRAS Harvey rat sarcoma viral oncogene homolog
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL2RA interleukin 2 receptor, alpha
IRF4 interferon regulatory factor 4
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG2 jagged 2
JAK2 Janus kinase 2
KAT2A K(lysine) acetyltransferase 2A
KAT5 K(lysine) acetyltransferase 5
KDM4B lysine (K)-specific demethylase 4B
KDM5B lysine (K)-specific demethylase 5B
KIAA1524 KIAA1524
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAX MYC associated factor X
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MINA MYC induced nuclear antigen
MIR148A microRNA 148a
MIR17HG miR-17-92 cluster host gene
MIR22 microRNA 22
MIR23A microRNA 23a
MIR23B microRNA 23b
MIR26A1 microRNA 26a-1
MIR28 microRNA 28
MIR29A microRNA 29a
MIR34A microRNA 34a
MIR363 microRNA 363
MIR375 microRNA 375
MIR378A microRNA 378a
MIR451A microRNA 451a
MIR9-1 microRNA 9-1
MIRLET7C microRNA let-7c
MLANA melan-A
MST1 macrophage stimulating 1
MTBP MDM2 binding protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
MXI1 MAX interactor 1, dimerization protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYCT1 myc target 1
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NFE2 nuclear factor, erythroid 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-1 NK3 homeobox 1
NMI N-myc (and STAT) interactor
NOTCH1 notch 1
NUAK1 NUAK family, SNF1-like kinase, 1
OTX2 orthodenticle homeobox 2
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD1 phospholipase D1, phosphatidylcholine-specific
PML promyelocytic leukemia
POU5F1 POU class 5 homeobox 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDM1 PR domain containing 1, with ZNF domain
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCD protein kinase C, delta
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTEN phosphatase and tensin homolog
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PVT1 Pvt1 oncogene (non-protein coding)
RB1 retinoblastoma 1
REST RE1-silencing transcription factor
RET ret proto-oncogene
RHOA ras homolog family member A
ROMO1 reactive oxygen species modulator 1
RUNX1 runt-related transcription factor 1
SAE1 SUMO1 activating enzyme subunit 1
SDC4 syndecan 4
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIN3B SIN3 transcription regulator family member B
SIRT1 sirtuin 1
SIRT7 sirtuin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPHK2 sphingosine kinase 2
SPI1 Spi-1 proto-oncogene
SRSF1 serine/arginine-rich splicing factor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STK38 serine/threonine kinase 38
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAL1 T-cell acute lymphocytic leukemia 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TOB2 transducer of ERBB2, 2
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP63 tumor protein p63
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRRAP transformation/transcription domain-associated protein
TTC5 tetratricopeptide repeat domain 5
UBA2 ubiquitin-like modifier activating enzyme 2
USP22 ubiquitin specific peptidase 22
USP28 ubiquitin specific peptidase 28
UTF1 undifferentiated embryonic cell transcription factor 1
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
WRN Werner syndrome, RecQ helicase-like
YBX1 Y box binding protein 1
YEATS4 YEATS domain containing 4
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB16 zinc finger and BTB domain containing 16
ZBTB17 zinc finger and BTB domain containing 17
ZFP36 ZFP36 ring finger protein
ZNF703 zinc finger protein 703