myd88 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description myeloid differentiation primary response 88|This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 4615)
Similar Terms
Downloads & Tools

Genes

88 genes co-occuring with the biological term myd88 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
AGER advanced glycosylation end product-specific receptor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BMX BMX non-receptor tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD300LF CD300 molecule-like family member f
CD79B CD79b molecule, immunoglobulin-associated beta
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK8 dedicator of cytokinesis 8
EGFR epidermal growth factor receptor
FAS Fas cell surface death receptor
FLII flightless I homolog (Drosophila)
FREM1 FRAS1 related extracellular matrix 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HDAC6 histone deacetylase 6
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL12A interleukin 12A
IL15 interleukin 15
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
JUN jun proto-oncogene
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MAL mal, T-cell differentiation protein
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MIR155 microRNA 155
MIR21 microRNA 21
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP12 NLR family, pyrin domain containing 12
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLAT plasminogen activator, tissue
PRKCE protein kinase C, epsilon
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOA ras homolog family member A
SARM1 sterile alpha and TIR motif containing 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD6 SMAD family member 6
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFB1 transforming growth factor, beta 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSC22D3 TSC22 domain family, member 3
UNC93B1 unc-93 homolog B1 (C. elegans)