myelodysplasia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Myelodysplastic syndromes are a class of syndromes which involve ineffective production (or dysplasia) of the myeloid class of blood cells.|A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) (Experimental Factor Ontology, EFO_0000198)
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Genes

22 genes co-occuring with the biological term myelodysplasia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATRX alpha thalassemia/mental retardation syndrome X-linked
CD177 CD177 molecule
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CSF3R colony stimulating factor 3 receptor (granulocyte)
DAPK1 death-associated protein kinase 1
FOXP1 forkhead box P1
GATA2 GATA binding protein 2
HFE hemochromatosis
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
JAK2 Janus kinase 2
MECOM MDS1 and EVI1 complex locus
NGF nerve growth factor (beta polypeptide)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
RUNX1 runt-related transcription factor 1
SRP72 signal recognition particle 72kDa
TERC telomerase RNA component
TGFB1 transforming growth factor, beta 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9