myelofibrosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue. (Human Disease Ontology, DOID_4971)
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Genes

213 genes co-occuring with the disease myelofibrosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
JAK2 Janus kinase 2 3.20262
JAK1 Janus kinase 1 2.04955
MPL MPL proto-oncogene, thrombopoietin receptor 1.92529
THPO thrombopoietin 1.85091
TET2 tet methylcytosine dioxygenase 2 1.80878
CD34 CD34 molecule 1.75822
ASXL1 additional sex combs like transcriptional regulator 1 1.64711
CALR calreticulin 1.52556
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.48516
CD177 CD177 molecule 1.40264
TGFB1 transforming growth factor, beta 1 1.33981
FIP1L1 factor interacting with PAPOLA and CPSF1 1.27519
SH2B3 SH2B adaptor protein 3 1.23126
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.23039
SRSF2 serine/arginine-rich splicing factor 2 1.19489
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.17035
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.15666
TYK2 tyrosine kinase 2 1.14475
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.13585
FEN1 flap structure-specific endonuclease 1 1.09881
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.09377
BCR breakpoint cluster region 1.07278
RARS arginyl-tRNA synthetase 1.05345
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.04672
NFE2 nuclear factor, erythroid 2 0.983479
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.978848
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.977585
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.976323
AGO2 argonaute RISC catalytic component 2 0.960378
JAK3 Janus kinase 3 0.959123
MPO myeloperoxidase 0.95369
CD33 CD33 molecule 0.950769
EPO erythropoietin 0.940364
FGFR1 fibroblast growth factor receptor 1 0.928346
JARID2 jumonji, AT rich interactive domain 2 0.866321
EPOR erythropoietin receptor 0.858134
IFNA2 interferon, alpha 2 0.852811
ALPPL2 alkaline phosphatase, placental-like 2 0.849126
ALPP alkaline phosphatase, placental 0.848716
ALPL alkaline phosphatase, liver/bone/kidney 0.848307
IFNA1 interferon, alpha 1 0.846669
PF4 platelet factor 4 0.842163
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.830279
FN1 fibronectin 1 0.821667
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.813052
SETBP1 SET binding protein 1 0.804436
FGF2 fibroblast growth factor 2 (basic) 0.795002
INTS3 integrator complex subunit 3 0.794181
FKBP5 FK506 binding protein 5 0.790902
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.789262
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.786394
KIAA0355 KIAA0355 0.776159
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.773296
SETD2 SET domain containing 2 0.754934
SH3D19 SH3 domain containing 19 0.747204
FLT3 fms-related tyrosine kinase 3 0.737865
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.719654
PTH parathyroid hormone 0.704742
VWF von Willebrand factor 0.697911
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0.660008
FXYD5 FXYD domain containing ion transport regulator 5 0.658026
SOX30 SRY (sex determining region Y)-box 30 0.653276
ZNF77 zinc finger protein 77 0.650903
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.649323
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.644192
RNF6 ring finger protein (C3H2C3 type) 6 0.636708
GARS glycyl-tRNA synthetase 0.631205
IL3 interleukin 3 0.629635
RUNX1 runt-related transcription factor 1 0.625319
HMGA2 high mobility group AT-hook 2 0.622183
CD19 CD19 molecule 0.609276
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.60186
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.592116
GPX8 glutathione peroxidase 8 (putative) 0.591337
F8 coagulation factor VIII, procoagulant component 0.58433
SCLT1 sodium channel and clathrin linker 1 0.582384
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.569941
ACPP acid phosphatase, prostate 0.568386
EMC10 ER membrane protein complex subunit 10 0.565666
ETV6 ets variant 6 0.557509
LYZ lysozyme 0.555568
CD7 CD7 molecule 0.546644
FKBP4 FK506 binding protein 4, 59kDa 0.541605
ELN elastin 0.535796
G6PD glucose-6-phosphate dehydrogenase 0.535796
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.535796
CD68 CD68 molecule 0.533088
RASA3 RAS p21 protein activator 3 0.527676
VAV1 vav 1 guanine nucleotide exchange factor 0.526132
CARD6 caspase recruitment domain family, member 6 0.512648
PKLR pyruvate kinase, liver and RBC 0.503824
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.503058
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 0.502675
HRAS Harvey rat sarcoma viral oncogene homolog 0.498085
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.493122
ARID4B AT rich interactive domain 4B (RBP1-like) 0.488549
MREG melanoregulin 0.477151
OLFM4 olfactomedin 4 0.474119
ORAI2 ORAI calcium release-activated calcium modulator 2 0.469954
TF transferrin 0.467684
FAIM Fas apoptotic inhibitory molecule 0.467306
SGMS2 sphingomyelin synthase 2 0.462772
PKM pyruvate kinase, muscle 0.437906
NAAA N-acylethanolamine acid amidase 0.430393
DEFA4 defensin, alpha 4, corticostatin 0.428891
SOCS2 suppressor of cytokine signaling 2 0.415398
BCL2L1 BCL2-like 1 0.400826
RPN1 ribophorin I 0.396353
MIR190A microRNA 190a 0.394863
HDAC9 histone deacetylase 9 0.387423
FGFR1OP FGFR1 oncogene partner 0.38111
FGF12 fibroblast growth factor 12 0.379626
STAT5B signal transducer and activator of transcription 5B 0.374809
JADE1 jade family PHD finger 1 0.374809
MASTL microtubule associated serine/threonine kinase-like 0.36704
PGM1 phosphoglucomutase 1 0.360026
ORAI3 ORAI calcium release-activated calcium modulator 3 0.353763
ZFPM1 zinc finger protein, FOG family member 1 0.344941
CD9 CD9 molecule 0.337242
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.33651
MACROD2 MACRO domain containing 2 0.33651
LOX lysyl oxidase 0.334315
SSBP2 single-stranded DNA binding protein 2 0.333218
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.332121
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.331756
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.325916
HYDIN HYDIN, axonemal central pair apparatus protein 0.312827
F2 coagulation factor II (thrombin) 0.30631
IRAK2 interleukin-1 receptor-associated kinase 2 0.303059
GAS2 growth arrest-specific 2 0.301615
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.299812
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.295492
TP53 tumor protein p53 0.295132
SCRIB scribbled planar cell polarity protein 0.294413
PDGFA platelet-derived growth factor alpha polypeptide 0.293334
FTH1 ferritin, heavy polypeptide 1 0.287235
FTL ferritin, light polypeptide 0.287235
HOXB6 homeobox B6 0.286519
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.282225
TAC4 tachykinin 4 (hemokinin) 0.279367
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.276514
SOCS3 suppressor of cytokine signaling 3 0.274376
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.265849
LCK LCK proto-oncogene, Src family tyrosine kinase 0.26514
CD36 CD36 molecule (thrombospondin receptor) 0.264431
SLCO2A1 solute carrier organic anion transporter family, member 2A1 0.263014
FAT4 FAT atypical cadherin 4 0.261952
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.260891
STIM2 stromal interaction molecule 2 0.25983
HAUS3 HAUS augmin-like complex, subunit 3 0.257005
FGR FGR proto-oncogene, Src family tyrosine kinase 0.257005
RNF19B ring finger protein 19B 0.255946
ZMYM2 zinc finger, MYM-type 2 0.255594
CD164 CD164 molecule, sialomucin 0.253831
PCM1 pericentriolar material 1 0.252422
MCAM melanoma cell adhesion molecule 0.251015
PDGFB platelet-derived growth factor beta polypeptide 0.248905
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.248203
GFI1B growth factor independent 1B transcription repressor 0.243645
HOXB8 homeobox B8 0.241895
CXCL12 chemokine (C-X-C motif) ligand 12 0.240847
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.238752
BMP10 bone morphogenetic protein 10 0.237357
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.235964
HOXB5 homeobox B5 0.235616
NGFR nerve growth factor receptor 0.233183
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.232489
CD59 CD59 molecule, complement regulatory protein 0.231448
KRAS Kirsten rat sarcoma viral oncogene homolog 0.230755
HMGB3 high mobility group box 3 0.228333
ARID4A AT rich interactive domain 4A (RBP1-like) 0.225917
HOXB3 homeobox B3 0.225229
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.22454
F5 coagulation factor V (proaccelerin, labile factor) 0.215992
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.212608
SEBOX SEBOX homeobox 0.212608
IL2RA interleukin 2 receptor, alpha 0.212608
CDK13 cyclin-dependent kinase 13 0.212271
IL1A interleukin 1, alpha 0.209918
NFIB nuclear factor I/B 0.209583
FGF1 fibroblast growth factor 1 (acidic) 0.207245
WT1 Wilms tumor 1 0.206913
STX16 syntaxin 16 0.201308
LYN LYN proto-oncogene, Src family tyrosine kinase 0.198386
DEK DEK proto-oncogene 0.195183
PCNA proliferating cell nuclear antigen 0.192344
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.192031
TNF tumor necrosis factor 0.191408
CD63 CD63 molecule 0.18621
CSF1 colony stimulating factor 1 (macrophage) 0.18621
EP300 E1A binding protein p300 0.185313
TIMP1 TIMP metallopeptidase inhibitor 1 0.183541
IFI27 interferon, alpha-inducible protein 27 0.178126
INSIG1 insulin induced gene 1 0.177301
GYPC glycophorin C (Gerbich blood group) 0.177029
PHYH phytanoyl-CoA 2-hydroxylase 0.176215
STAT5A signal transducer and activator of transcription 5A 0.176215
MIR223 microRNA 223 0.175679
GRB2 growth factor receptor-bound protein 2 0.175679
HLA-C major histocompatibility complex, class I, C 0.173832
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 0.170544
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.169571
CD5 CD5 molecule 0.169091
CSF3 colony stimulating factor 3 (granulocyte) 0.168854
IGHA1 immunoglobulin heavy constant alpha 1 0.166995
CLEC11A C-type lectin domain family 11, member A 0.165435
BMP8B bone morphogenetic protein 8b 0.165001
BMPR1B bone morphogenetic protein receptor, type IB 0.164359
HDAC6 histone deacetylase 6 0.162109
NF1 neurofibromin 1 0.160387
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.160387
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.159838
CPSF3L cleavage and polyadenylation specific factor 3-like 0.158778