myelofibrosis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue. (Human Disease Ontology, DOID_4971)
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Genes

81 genes co-occuring with the biological term myelofibrosis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ASXL1 additional sex combs like transcriptional regulator 1
BMP1 bone morphogenetic protein 1
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
CALR calreticulin
CD14 CD14 molecule
CD177 CD177 molecule
CD34 CD34 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CRP C-reactive protein, pentraxin-related
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ENG endoglin
ERCC2 excision repair cross-complementation group 2
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FKBP5 FK506 binding protein 5
GATA1 GATA binding protein 1 (globin transcription factor 1)
HDAC11 histone deacetylase 11
HDAC9 histone deacetylase 9
HMGA2 high mobility group AT-hook 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL15 interleukin 15
IL17A interleukin 17A
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT7 keratin 7, type II
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MCAM melanoma cell adhesion molecule
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP8 matrix metallopeptidase 8
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFE2 nuclear factor, erythroid 2
NOG noggin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORAI1 ORAI calcium release-activated calcium modulator 1
ORAI2 ORAI calcium release-activated calcium modulator 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFB platelet-derived growth factor beta polypeptide
PHF20 PHD finger protein 20
PML promyelocytic leukemia
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTH parathyroid hormone
RARB retinoic acid receptor, beta
RUNX1 runt-related transcription factor 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SOCS3 suppressor of cytokine signaling 3
SRSF2 serine/arginine-rich splicing factor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STIM1 stromal interaction molecule 1
STIM2 stromal interaction molecule 2
TAC1 tachykinin, precursor 1
TEK TEK tyrosine kinase, endothelial
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TPO thyroid peroxidase
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
VEGFA vascular endothelial growth factor A
ZFPM1 zinc finger protein, FOG family member 1