nadolol-3020 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

191 genes differentially expressed following the nadolol-3020 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACVR1B activin A receptor, type IB
ADRB1 adrenoceptor beta 1
AGXT alanine-glyoxylate aminotransferase
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APP amyloid beta (A4) precursor protein
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ASPH aspartate beta-hydroxylase
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP7 bone morphogenetic protein 7
BPY2 basic charge, Y-linked, 2
CDK19 cyclin-dependent kinase 19
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPB2 carboxypeptidase B2 (plasma)
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CUL3 cullin 3
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DGKE diacylglycerol kinase, epsilon 64kDa
DOCK5 dedicator of cytokinesis 5
EPAS1 endothelial PAS domain protein 1
EPHB2 EPH receptor B2
FAM110B family with sequence similarity 110, member B
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FSD1 fibronectin type III and SPRY domain containing 1
FXYD3 FXYD domain containing ion transport regulator 3
GIF gastric intrinsic factor (vitamin B synthesis)
GOLGA2P5 golgin A2 pseudogene 5
GPR161 G protein-coupled receptor 161
GRAMD1B GRAM domain containing 1B
GRM4 glutamate receptor, metabotropic 4
GSPT1 G1 to S phase transition 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
INS insulin
IRF5 interferon regulatory factor 5
ITGB4 integrin, beta 4
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIAA0087 KIAA0087
KLF5 Kruppel-like factor 5 (intestinal)
KRT23 keratin 23, type I
LAMP1 lysosomal-associated membrane protein 1
LMOD1 leiomodin 1 (smooth muscle)
LRRC48 leucine rich repeat containing 48
MBNL1 muscleblind-like splicing regulator 1
MNMIP1 manchette microtubule inner protein 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYLK myosin light chain kinase
NCKIPSD NCK interacting protein with SH3 domain
NEFM neurofilament, medium polypeptide
NMT1 N-myristoyltransferase 1
OCM2 oncomodulin 2
ONECUT2 one cut homeobox 2
OPCML opioid binding protein/cell adhesion molecule-like
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAPOLB poly(A) polymerase beta (testis specific)
PDE4DIP phosphodiesterase 4D interacting protein
PDIA2 protein disulfide isomerase family A, member 2
PDX1 pancreatic and duodenal homeobox 1
PIGR polymeric immunoglobulin receptor
PLAC1 placenta-specific 1
PLD2 phospholipase D2
PRKCA protein kinase C, alpha
PRKG2 protein kinase, cGMP-dependent, type II
PROS1 protein S (alpha)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTHLH parathyroid hormone-like hormone
PTTG2 pituitary tumor-transforming 2
RB1 retinoblastoma 1
RBP4 retinol binding protein 4, plasma
RNF122 ring finger protein 122
SCGB2A1 secretoglobin, family 2A, member 1
SERHL2 serine hydrolase-like 2
SLC12A8 solute carrier family 12, member 8
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMAD1 SMAD family member 1
SMC1A structural maintenance of chromosomes 1A
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR2B small proline-rich protein 2B
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
SULT4A1 sulfotransferase family 4A, member 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TMOD1 tropomodulin 1
TMPRSS4 transmembrane protease, serine 4
TRPM1 transient receptor potential cation channel, subfamily M, member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR1 WD repeat domain 1
WISP3 WNT1 inducible signaling pathway protein 3
XDH xanthine dehydrogenase
ZNF280B zinc finger protein 280B
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACPP acid phosphatase, prostate
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGB androglobin
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARG1 arginase 1
ARHGAP10 Rho GTPase activating protein 10
BHMT2 betaine--homocysteine S-methyltransferase 2
C14ORF93 chromosome 14 open reading frame 93
C3ORF14 chromosome 3 open reading frame 14
C3ORF18 chromosome 3 open reading frame 18
C8A complement component 8, alpha polypeptide
C8ORF44 chromosome 8 open reading frame 44
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMKMT calmodulin-lysine N-methyltransferase
CCDC69 coiled-coil domain containing 69
CEP295 centrosomal protein 295kDa
CFAP69 cilia and flagella associated protein 69
CISH cytokine inducible SH2-containing protein
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPN2 carboxypeptidase N, polypeptide 2
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DOLK dolichol kinase
DPYS dihydropyrimidinase
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR35 G protein-coupled receptor 35
GUSBP3 glucuronidase, beta pseudogene 3
HCG4 HLA complex group 4 (non-protein coding)
HDAC7 histone deacetylase 7
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AJ histone cluster 1, H2aj
HIST1H3I histone cluster 1, H3i
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC10 homeobox C10
IFNA14 interferon, alpha 14
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL12B interleukin 12B
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIAA0319L KIAA0319-like
KPTN kaptin (actin binding protein)
LOC57399 uncharacterized gastric protein ZA52P
MAP6D1 MAP6 domain containing 1
MFSD11 major facilitator superfamily domain containing 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH4 myosin, heavy chain 4, skeletal muscle
MYO15A myosin XVA
NXPE3 neurexophilin and PC-esterase domain family, member 3
PCDHGB6 protocadherin gamma subfamily B, 6
PFN2 profilin 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLH polymerase (DNA directed), eta
POM121 POM121 transmembrane nucleoporin
PRB3 proline-rich protein BstNI subfamily 3
PROX1 prospero homeobox 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QSER1 glutamine and serine rich 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCAN3 RCAN family member 3
RIBC2 RIB43A domain with coiled-coils 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCD5 stearoyl-CoA desaturase 5
SCN5A sodium channel, voltage gated, type V alpha subunit
SH2D3C SH2 domain containing 3C
SIGLEC15 sialic acid binding Ig-like lectin 15
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC10A3 solute carrier family 10, member 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX12 SRY (sex determining region Y)-box 12
SPATA20 spermatogenesis associated 20
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYNDIG1 synapse differentiation inducing 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAGLN transgelin
TAGLN3 transgelin 3
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM246 transmembrane protein 246
TTC30A tetratricopeptide repeat domain 30A
UBQLN4 ubiquilin 4
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZFHX3 zinc finger homeobox 3
ZNF254 zinc finger protein 254
ZNF280A zinc finger protein 280A
ZNF749 zinc finger protein 749
ZNF816 zinc finger protein 816