nadolol-3359 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the nadolol-3359 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACOX2 acyl-CoA oxidase 2, branched chain
ACTC1 actin, alpha, cardiac muscle 1
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AFF1 AF4/FMR2 family, member 1
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP3 aquaporin 3 (Gill blood group)
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
AUTS2 autism susceptibility candidate 2
BCO1 beta-carotene oxygenase 1
C11ORF30 chromosome 11 open reading frame 30
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC93 coiled-coil domain containing 93
CD248 CD248 molecule, endosialin
CERS4 ceramide synthase 4
CLSTN3 calsyntenin 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRYGD crystallin, gamma D
CTSS cathepsin S
DEAF1 DEAF1 transcription factor
DMP1 dentin matrix acidic phosphoprotein 1
DTNA dystrobrevin, alpha
EFNB3 ephrin-B3
EGR1 early growth response 1
ELL elongation factor RNA polymerase II
FCMR Fc fragment of IgM receptor
FMO5 flavin containing monooxygenase 5
FRMD8 FERM domain containing 8
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GPR3 G protein-coupled receptor 3
GRM6 glutamate receptor, metabotropic 6
HEG1 heart development protein with EGF-like domains 1
HEMK1 HemK methyltransferase family member 1
HIST1H2BJ histone cluster 1, H2bj
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KCNK10 potassium channel, two pore domain subfamily K, member 10
KIAA0125 KIAA0125
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRTM2 leucine rich repeat transmembrane neuronal 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1A microtubule-associated protein 1A
MAPT microtubule-associated protein tau
MCOLN1 mucolipin 1
MGC12488
MST1L macrophage stimulating 1-like
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEUROD4 neuronal differentiation 4
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NME5 NME/NM23 family member 5
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP214 nucleoporin 214kDa
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PEX3 peroxisomal biogenesis factor 3
PLCH1 phospholipase C, eta 1
PLCH2 phospholipase C, eta 2
PLXNB3 plexin B3
POMT2 protein-O-mannosyltransferase 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
RAB11B RAB11B, member RAS oncogene family
RAB33A RAB33A, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RND1 Rho family GTPase 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RUSC2 RUN and SH3 domain containing 2
SAMD4A sterile alpha motif domain containing 4A
SIRT5 sirtuin 5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SOCS3 suppressor of cytokine signaling 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRSF7 serine/arginine-rich splicing factor 7
STAB2 stabilin 2
STMN1 stathmin 1
SUGP1 SURP and G patch domain containing 1
TAS2R1 taste receptor, type 2, member 1
TBXA2R thromboxane A2 receptor
TDRD3 tudor domain containing 3
TEF thyrotrophic embryonic factor
TEX14 testis expressed 14
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM4SF1 transmembrane 4 L six family member 1
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TSPAN9 tetraspanin 9
UCN urocortin
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACTL8 actin-like 8
ADAMTSL3 ADAMTS-like 3
AMPD1 adenosine monophosphate deaminase 1
ARHGAP4 Rho GTPase activating protein 4
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEGAIN brain-enriched guanylate kinase-associated
C11ORF16 chromosome 11 open reading frame 16
C8ORF44 chromosome 8 open reading frame 44
CCDC121 coiled-coil domain containing 121
CCDC71 coiled-coil domain containing 71
CDH10 cadherin 10, type 2 (T2-cadherin)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHRM3 cholinergic receptor, muscarinic 3
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNTFR ciliary neurotrophic factor receptor
CNTN1 contactin 1
CUL9 cullin 9
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DCBLD2 discoidin, CUB and LCCL domain containing 2
DTX2 deltex 2, E3 ubiquitin ligase
EDAR ectodysplasin A receptor
ENO3 enolase 3 (beta, muscle)
EVPL envoplakin
FADS2 fatty acid desaturase 2
FAM120C family with sequence similarity 120C
FAM192A family with sequence similarity 192, member A
FAM212B family with sequence similarity 212, member B
FAM46C family with sequence similarity 46, member C
FANCE Fanconi anemia, complementation group E
FGF23 fibroblast growth factor 23
FGGY FGGY carbohydrate kinase domain containing
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXI1 forkhead box I1
GFI1 growth factor independent 1 transcription repressor
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPR143 G protein-coupled receptor 143
GSTTP1 glutathione S-transferase theta pseudogene 1
HDAC11 histone deacetylase 11
HDAC5 histone deacetylase 5
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMB major histocompatibility complex, class II, DM beta
HOXC5 homeobox C5
IFNAR1 interferon (alpha, beta and omega) receptor 1
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA0319L KIAA0319-like
KLHL25 kelch-like family member 25
KRT31 keratin 31, type I
LIME1 Lck interacting transmembrane adaptor 1
LRP2 low density lipoprotein receptor-related protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA6 melanoma antigen family A6
MORN1 MORN repeat containing 1
MRPL41 mitochondrial ribosomal protein L41
MYOZ3 myozenin 3
NELL2 NEL-like 2 (chicken)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA5 protocadherin alpha 5
PENK proenkephalin
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POPDC3 popeye domain containing 3
PRODH proline dehydrogenase (oxidase) 1
QPCT glutaminyl-peptide cyclotransferase
RAB3A RAB3A, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RELN reelin
RIBC2 RIB43A domain with coiled-coils 2
RNF39 ring finger protein 39
RPL13P5 ribosomal protein L13 pseudogene 5
SCARA3 scavenger receptor class A, member 3
SCGB2A2 secretoglobin, family 2A, member 2
SLC16A6 solute carrier family 16, member 6
SOX12 SRY (sex determining region Y)-box 12
SPINK5 serine peptidase inhibitor, Kazal type 5
TBC1D19 TBC1 domain family, member 19
TCTN2 tectonic family member 2
TDRD12 tudor domain containing 12
TGFBR3 transforming growth factor, beta receptor III
THRB thyroid hormone receptor, beta
TM7SF3 transmembrane 7 superfamily member 3
TMC7 transmembrane channel-like 7
TMEM212 transmembrane protein 212
TRDMT1 tRNA aspartic acid methyltransferase 1
TUBA4B tubulin, alpha 4b
VPS9D1 VPS9 domain containing 1
XDH xanthine dehydrogenase
ZFHX2 zinc finger homeobox 2