nadolol-4021 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the nadolol-4021 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
A4GALT alpha 1,4-galactosyltransferase
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ADAM19 ADAM metallopeptidase domain 19
ADAM23 ADAM metallopeptidase domain 23
ADGRL4 adhesion G protein-coupled receptor L4
ANP32A-IT1 ANP32A intronic transcript 1
ASCL1 achaete-scute family bHLH transcription factor 1
BEND5 BEN domain containing 5
BMP8A bone morphogenetic protein 8a
C1ORF54 chromosome 1 open reading frame 54
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMK1G calcium/calmodulin-dependent protein kinase IG
CDC14B cell division cycle 14B
CDH8 cadherin 8, type 2
CDK20 cyclin-dependent kinase 20
CELA2A chymotrypsin-like elastase family, member 2A
CEP295 centrosomal protein 295kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN18 claudin 18
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISP2 cysteine-rich secretory protein 2
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CTSS cathepsin S
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHODH dihydroorotate dehydrogenase (quinone)
DPP4 dipeptidyl-peptidase 4
EFR3B EFR3 homolog B (S. cerevisiae)
EHD2 EH-domain containing 2
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
EXD3 exonuclease 3'-5' domain containing 3
GLP1R glucagon-like peptide 1 receptor
GPR63 G protein-coupled receptor 63
HBB hemoglobin, beta
HCRTR1 hypocretin (orexin) receptor 1
ICOSLG inducible T-cell co-stimulator ligand
IFFO1 intermediate filament family orphan 1
KIF25 kinesin family member 25
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LOXL3 lysyl oxidase-like 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAPT microtubule-associated protein tau
MARS methionyl-tRNA synthetase
MCF2L MCF.2 cell line derived transforming sequence-like
MED6 mediator complex subunit 6
MEP1B meprin A, beta
MINK1 misshapen-like kinase 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MST1 macrophage stimulating 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NEK1 NIMA-related kinase 1
NIPAL3 NIPA-like domain containing 3
NNMT nicotinamide N-methyltransferase
NOTCH3 notch 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRDM14 PR domain containing 14
PRKCI protein kinase C, iota
RAD51B RAD51 paralog B
RASAL1 RAS protein activator like 1 (GAP1 like)
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RIN3 Ras and Rab interactor 3
RNGTT RNA guanylyltransferase and 5'-phosphatase
S1PR1 sphingosine-1-phosphate receptor 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPACA1 sperm acrosome associated 1
STRN striatin, calmodulin binding protein
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYCE1L synaptonemal complex central element protein 1-like
SYMPK symplekin
TBX2 T-box 2
TCEAL2 transcription elongation factor A (SII)-like 2
TCP10L t-complex 10-like
THBD thrombomodulin
TLX2 T-cell leukemia homeobox 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRA2A transformer 2 alpha homolog (Drosophila)
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TSPY1 testis specific protein, Y-linked 1
TTC9 tetratricopeptide repeat domain 9
TUBA3C tubulin, alpha 3c
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WT1-AS WT1 antisense RNA
ZCCHC11 zinc finger, CCHC domain containing 11
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF236 zinc finger protein 236
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
AGMAT agmatine ureohydrolase (agmatinase)
AHDC1 AT hook, DNA binding motif, containing 1
ALS2CL ALS2 C-terminal like
ARC activity-regulated cytoskeleton-associated protein
ARHGAP22 Rho GTPase activating protein 22
B9D2 B9 protein domain 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BST1 bone marrow stromal cell antigen 1
BTF3P11 basic transcription factor 3 pseudogene 11
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF105 chromosome 14 open reading frame 105
C17ORF53 chromosome 17 open reading frame 53
C19ORF40 chromosome 19 open reading frame 40
C5ORF42 chromosome 5 open reading frame 42
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC71 coiled-coil domain containing 71
CD79B CD79b molecule, immunoglobulin-associated beta
CLDN11 claudin 11
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNGB3 cyclic nucleotide gated channel beta 3
CNR2 cannabinoid receptor 2 (macrophage)
COL9A3 collagen, type IX, alpha 3
CRYBA2 crystallin, beta A2
CTC1 CTS telomere maintenance complex component 1
CYB5R2 cytochrome b5 reductase 2
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
ENO3 enolase 3 (beta, muscle)
EPN1 epsin 1
ERO1LB ERO1-like beta (S. cerevisiae)
EVPL envoplakin
EXO5 exonuclease 5
FANCC Fanconi anemia, complementation group C
FBRS fibrosin
FGF21 fibroblast growth factor 21
FRMPD1 FERM and PDZ domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FSD1 fibronectin type III and SPRY domain containing 1
GNL1 guanine nucleotide binding protein-like 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR19 G protein-coupled receptor 19
GRAMD1B GRAM domain containing 1B
GREB1L growth regulation by estrogen in breast cancer-like
HIST1H3B histone cluster 1, H3b
IFI6 interferon, alpha-inducible protein 6
IFNA17 interferon, alpha 17
IGLL1 immunoglobulin lambda-like polypeptide 1
IPO8 importin 8
ITPKA inositol-trisphosphate 3-kinase A
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
LRRC15 leucine rich repeat containing 15
LTC4S leukotriene C4 synthase
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MACROD1 MACRO domain containing 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MNMIP1 manchette microtubule inner protein 1
MTCP1 mature T-cell proliferation 1
MX1 MX dynamin-like GTPase 1
NOL10 nucleolar protein 10
NPM3 nucleophosmin/nucleoplasmin 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PALMD palmdelphin
PARD6A par-6 family cell polarity regulator alpha
PAX9 paired box 9
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PIP prolactin-induced protein
PLD3 phospholipase D family, member 3
POLL polymerase (DNA directed), lambda
RAI2 retinoic acid induced 2
RNF126P1 ring finger protein 126 pseudogene 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC22A14 solute carrier family 22, member 14
SLC35F6 solute carrier family 35, member F6
SSTR4 somatostatin receptor 4
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TH tyrosine hydroxylase
TMEM212 transmembrane protein 212
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TXK TXK tyrosine kinase
WDR18 WD repeat domain 18
WFDC2 WAP four-disulfide core domain 2
ZNF234 zinc finger protein 234
ZNF268 zinc finger protein 268
ZNF280A zinc finger protein 280A
ZXDB zinc finger, X-linked, duplicated B