nalbuphine-1379 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nalbuphine-1379 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVRL1 activin A receptor type II-like 1
ADRBK2 adrenergic, beta, receptor kinase 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATF5 activating transcription factor 5
BCL7C B-cell CLL/lymphoma 7C
BGN biglycan
BIN2 bridging integrator 2
C2CD2L C2CD2-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN3 calpain 3, (p94)
CCDC40 coiled-coil domain containing 40
CD68 CD68 molecule
CHERP calcium homeostasis endoplasmic reticulum protein
CLIC4 chloride intracellular channel 4
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CREB3 cAMP responsive element binding protein 3
CTH cystathionine gamma-lyase
CTNNBIP1 catenin, beta interacting protein 1
CTRL chymotrypsin-like
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLX2 distal-less homeobox 2
DST dystonin
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F4 E2F transcription factor 4, p107/p130-binding
ELF2 E74-like factor 2 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOSF1 enolase superfamily member 1
FAM3A family with sequence similarity 3, member A
FASTK Fas-activated serine/threonine kinase
FBXO3 F-box protein 3
FYB FYN binding protein
GIMAP5 GTPase, IMAP family member 5
GSTM4 glutathione S-transferase mu 4
HIST1H4J histone cluster 1, H4j
HOXA11 homeobox A11
HUS1 HUS1 checkpoint homolog (S. pombe)
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIFAP3 kinesin-associated protein 3
KLF13 Kruppel-like factor 13
KRI1 KRI1 homolog (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
METTL7A methyltransferase like 7A
MICALL1 MICAL-like 1
MPC1 mitochondrial pyruvate carrier 1
MRC2 mannose receptor, C type 2
MRPL33 mitochondrial ribosomal protein L33
MSH3 mutS homolog 3
MST1 macrophage stimulating 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NPFFR1 neuropeptide FF receptor 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NXPH3 neurexophilin 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PGK1 phosphoglycerate kinase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCD1 phospholipase C, delta 1
PLIN2 perilipin 2
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRRC1 proline-rich coiled-coil 1
PSG4 pregnancy specific beta-1-glycoprotein 4
PSG9 pregnancy specific beta-1-glycoprotein 9
RAB5C RAB5C, member RAS oncogene family
RANBP3 RAN binding protein 3
RET ret proto-oncogene
RHOD ras homolog family member D
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SMG9 SMG9 nonsense mediated mRNA decay factor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPOP speckle-type POZ protein
SPPL2B signal peptide peptidase like 2B
SUGP1 SURP and G patch domain containing 1
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TES testin LIM domain protein
TFG TRK-fused gene
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNK2 tyrosine kinase, non-receptor, 2
TRIP11 thyroid hormone receptor interactor 11
TUBA4B tubulin, alpha 4b
UGCG UDP-glucose ceramide glucosyltransferase
USF2 upstream transcription factor 2, c-fos interacting
USO1 USO1 vesicle transport factor
WDR46 WD repeat domain 46
WSB1 WD repeat and SOCS box containing 1
YLPM1 YLP motif containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2B activin A receptor, type IIB
ADAM15 ADAM metallopeptidase domain 15
ADGRA3 adhesion G protein-coupled receptor A3
ANXA6 annexin A6
APOC4 apolipoprotein C-IV
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ASCC1 activating signal cointegrator 1 complex subunit 1
ATG9A autophagy related 9A
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATXN2 ataxin 2
BTNL3 butyrophilin-like 3
C19ORF40 chromosome 19 open reading frame 40
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CD151 CD151 molecule (Raph blood group)
CDCA3 cell division cycle associated 3
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CTAGE9 CTAGE family, member 9
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DIXDC1 DIX domain containing 1
DOK2 docking protein 2, 56kDa
DSN1 DSN1, MIS12 kinetochore complex component
DTWD1 DTW domain containing 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
ECD ecdysoneless homolog (Drosophila)
FAM114A2 family with sequence similarity 114, member A2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GPR137B G protein-coupled receptor 137B
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTPBP6 GTP binding protein 6 (putative)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IMPAD1 inositol monophosphatase domain containing 1
INO80D INO80 complex subunit D
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KCNK5 potassium channel, two pore domain subfamily K, member 5
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MAGOHB mago-nashi homolog B (Drosophila)
MAPK12 mitogen-activated protein kinase 12
MED17 mediator complex subunit 17
MGA MGA, MAX dimerization protein
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRGBP MRG/MORF4L binding protein
MRPL13 mitochondrial ribosomal protein L13
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NAP1L4 nucleosome assembly protein 1-like 4
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NHEJ1 nonhomologous end-joining factor 1
NRBP1 nuclear receptor binding protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OGFRL1 opioid growth factor receptor-like 1
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PADI1 peptidyl arginine deiminase, type I
PAK1IP1 PAK1 interacting protein 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHGB5 protocadherin gamma subfamily B, 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PROSER1 proline and serine rich 1
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RBM47 RNA binding motif protein 47
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RHOC ras homolog family member C
RNF123 ring finger protein 123
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGA Ras-related GTP binding A
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC35A5 solute carrier family 35, member A5
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLMO2 slowmo homolog 2 (Drosophila)
SLN sarcolipin
SPX spexin hormone
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBCCD1 TBCC domain containing 1
TEX40 testis expressed 40
TUBA3C tubulin, alpha 3c
UBXN2B UBX domain protein 2B
USB1 U6 snRNA biogenesis 1
WDR19 WD repeat domain 19
XDH xanthine dehydrogenase
YEATS4 YEATS domain containing 4
YY2 YY2 transcription factor
ZBTB48 zinc finger and BTB domain containing 48
ZNF263 zinc finger protein 263
ZNF529 zinc finger protein 529