nalbuphine-2063 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the nalbuphine-2063 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD12 ankyrin repeat domain 12
ARL1 ADP-ribosylation factor-like 1
ARTN artemin
ATP10A ATPase, class V, type 10A
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C22ORF29 chromosome 22 open reading frame 29
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CCL20 chemokine (C-C motif) ligand 20
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CORO1A coronin, actin binding protein, 1A
EIF3A eukaryotic translation initiation factor 3, subunit A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV5 ets variant 5
EXOSC2 exosome component 2
FGF1 fibroblast growth factor 1 (acidic)
FGFR1 fibroblast growth factor receptor 1
FLOT2 flotillin 2
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLCE glucuronic acid epimerase
GPR19 G protein-coupled receptor 19
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER3 homer scaffolding protein 3
HOOK1 hook microtubule-tethering protein 1
IFT122 intraflagellar transport 122
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
IQSEC2 IQ motif and Sec7 domain 2
KDM2A lysine (K)-specific demethylase 2A
KIAA0930 KIAA0930
KIRREL kin of IRRE like (Drosophila)
KLHL36 kelch-like family member 36
KRIT1 KRIT1, ankyrin repeat containing
LINC00339 long intergenic non-protein coding RNA 339
LRRK1 leucine-rich repeat kinase 1
LYPD1 LY6/PLAUR domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST2 microtubule associated serine/threonine kinase 2
MEF2C myocyte enhancer factor 2C
MPI mannose phosphate isomerase
MUC1 mucin 1, cell surface associated
MYRF myelin regulatory factor
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NFIB nuclear factor I/B
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUMA1 nuclear mitotic apparatus protein 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACS1 phosphofurin acidic cluster sorting protein 1
PCDH1 protocadherin 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDCD6 programmed cell death 6
PDGFA platelet-derived growth factor alpha polypeptide
PER3 period circadian clock 3
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PKP4 plakophilin 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POM121 POM121 transmembrane nucleoporin
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PTPRE protein tyrosine phosphatase, receptor type, E
RABGAP1L RAB GTPase activating protein 1-like
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM42 RNA binding motif protein 42
RHOT2 ras homolog family member T2
S1PR1 sphingosine-1-phosphate receptor 1
SAYSD1 SAYSVFN motif domain containing 1
SCAPER S-phase cyclin A-associated protein in the ER
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SMAD5 SMAD family member 5
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOGA1 suppressor of glucose, autophagy associated 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCF25 transcription factor 25 (basic helix-loop-helix)
TCF4 transcription factor 4
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLN2 talin 2
TRIM45 tripartite motif containing 45
TTC38 tetratricopeptide repeat domain 38
TTLL7 tubulin tyrosine ligase-like family member 7
U2SURP U2 snRNP-associated SURP domain containing
UGT8 UDP glycosyltransferase 8
XYLB xylulokinase homolog (H. influenzae)
ZNF552 zinc finger protein 552
ZNF587 zinc finger protein 587

decreased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOL6 apolipoprotein L, 6
ARHGAP12 Rho GTPase activating protein 12
AXIN1 axin 1
BCAS3 breast carcinoma amplified sequence 3
BCL9 B-cell CLL/lymphoma 9
BMP15 bone morphogenetic protein 15
BRAF B-Raf proto-oncogene, serine/threonine kinase
C16ORF59 chromosome 16 open reading frame 59
C19ORF40 chromosome 19 open reading frame 40
CCDC130 coiled-coil domain containing 130
CCDC85C coiled-coil domain containing 85C
CHMP6 charged multivesicular body protein 6
CLCN5 chloride channel, voltage-sensitive 5
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CRYBA2 crystallin, beta A2
DCLRE1A DNA cross-link repair 1A
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP8 dual specificity phosphatase 8
ECI1 enoyl-CoA delta isomerase 1
ERCC2 excision repair cross-complementation group 2
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM53B family with sequence similarity 53, member B
FCHSD2 FCH and double SH3 domains 2
FURIN furin (paired basic amino acid cleaving enzyme)
GALT galactose-1-phosphate uridylyltransferase
GLI3 GLI family zinc finger 3
GPR1 G protein-coupled receptor 1
GRWD1 glutamate-rich WD repeat containing 1
GTPBP2 GTP binding protein 2
HDAC5 histone deacetylase 5
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
HIST1H2AG histone cluster 1, H2ag
HMHA1 histocompatibility (minor) HA-1
HOXB13 homeobox B13
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5C lysine (K)-specific demethylase 5C
KIFAP3 kinesin-associated protein 3
KRT15 keratin 15, type I
KRT8P12 keratin 8 pseudogene 12
LHX6 LIM homeobox 6
LIMS2 LIM and senescent cell antigen-like domains 2
LINS lines homolog (Drosophila)
LY6G5C lymphocyte antigen 6 complex, locus G5C
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEH1 melanoma antigen family H1
MAPK3 mitogen-activated protein kinase 3
MGMT O-6-methylguanine-DNA methyltransferase
MNX1 motor neuron and pancreas homeobox 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NGF nerve growth factor (beta polypeptide)
NT5M 5',3'-nucleotidase, mitochondrial
ORAI3 ORAI calcium release-activated calcium modulator 3
PAQR4 progestin and adipoQ receptor family member IV
PARP3 poly (ADP-ribose) polymerase family, member 3
PEX26 peroxisomal biogenesis factor 26
PHLDA3 pleckstrin homology-like domain, family A, member 3
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRAME preferentially expressed antigen in melanoma
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK7 protein tyrosine kinase 7 (inactive)
RAB4B RAB4B, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
SAMD9 sterile alpha motif domain containing 9
SDC3 syndecan 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD1B SET domain containing 1B
SH3BGR SH3 domain binding glutamate-rich protein
SHPK sedoheptulokinase
SIRT2 sirtuin 2
SIX1 SIX homeobox 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC35F6 solute carrier family 35, member F6
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYT17 synaptotagmin XVII
TGFB3 transforming growth factor, beta 3
TKFC triokinase/FMN cyclase
TMC5 transmembrane channel-like 5
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPCN1 two pore segment channel 1
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAIP TRAF interacting protein
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3D tubulin, alpha 3d
USP18 ubiquitin specific peptidase 18
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZC3H12A zinc finger CCCH-type containing 12A
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF574 zinc finger protein 574
ZNF813 zinc finger protein 813
ZNF862 zinc finger protein 862