naloxone-2006 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the naloxone-2006 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACAN aggrecan
ACSL6 acyl-CoA synthetase long-chain family member 6
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APAF1 apoptotic peptidase activating factor 1
APOC4 apolipoprotein C-IV
ARL4C ADP-ribosylation factor-like 4C
ARMC6 armadillo repeat containing 6
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
ATXN2L ataxin 2-like
AXIN1 axin 1
BRAP BRCA1 associated protein
C1ORF61 chromosome 1 open reading frame 61
C4BPA complement component 4 binding protein, alpha
CAMK1G calcium/calmodulin-dependent protein kinase IG
CBY1 chibby homolog 1 (Drosophila)
CD101 CD101 molecule
CD82 CD82 molecule
CELA3B chymotrypsin-like elastase family, member 3B
CETN1 centrin, EF-hand protein, 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
COL4A2 collagen, type IV, alpha 2
CREM cAMP responsive element modulator
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DST dystonin
E2F1 E2F transcription factor 1
ERCC8 excision repair cross-complementation group 8
ESRRA estrogen-related receptor alpha
FBXO42 F-box protein 42
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FSCN1 fascin actin-bundling protein 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLGA2 golgin A2
GPX2 glutathione peroxidase 2
HEMK1 HemK methyltransferase family member 1
HEXA hexosaminidase A (alpha polypeptide)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HK2 hexokinase 2
ICAM2 intercellular adhesion molecule 2
IRGQ immunity-related GTPase family, Q
ITSN1 intersectin 1 (SH3 domain protein)
IVD isovaleryl-CoA dehydrogenase
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF6 Kruppel-like factor 6
LEFTY2 left-right determination factor 2
MAGED2 melanoma antigen family D2
MAGOH2P mago-nashi homolog 2, pseudogene
MCM3AP-AS1 MCM3AP antisense RNA 1
MED13L mediator complex subunit 13-like
MED27 mediator complex subunit 27
MFSD11 major facilitator superfamily domain containing 11
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NHEJ1 nonhomologous end-joining factor 1
NRGN neurogranin (protein kinase C substrate, RC3)
PAPOLG poly(A) polymerase gamma
PAPPA2 pappalysin 2
PCIF1 PDX1 C-terminal inhibiting factor 1
PDCD6 programmed cell death 6
PHF21A PHD finger protein 21A
PRB1 proline-rich protein BstNI subfamily 1
PVT1 Pvt1 oncogene (non-protein coding)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS1 regulator of G-protein signaling 1
RPAP1 RNA polymerase II associated protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP4 secretory carrier membrane protein 4
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A44 solute carrier family 25, member 44
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOGA1 suppressor of glucose, autophagy associated 1
SPTB spectrin, beta, erythrocytic
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TBCD tubulin folding cofactor D
TCL1A T-cell leukemia/lymphoma 1A
TCP11L1 t-complex 11, testis-specific-like 1
TDRD3 tudor domain containing 3
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM45A transmembrane protein 45A
TMEM62 transmembrane protein 62
TRA T cell receptor alpha locus
TRIM29 tripartite motif containing 29
UBE2O ubiquitin-conjugating enzyme E2O
UBOX5 U-box domain containing 5
VWA8 von Willebrand factor A domain containing 8
WDR13 WD repeat domain 13
WDR61 WD repeat domain 61
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XYLT2 xylosyltransferase II
YIPF2 Yip1 domain family, member 2
YLPM1 YLP motif containing 1
ZBED1 zinc finger, BED-type containing 1
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF335 zinc finger protein 335

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABT1 activator of basal transcription 1
ALPK1 alpha-kinase 1
ANXA2P2 annexin A2 pseudogene 2
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATXN2 ataxin 2
B3GNT1
BAX BCL2-associated X protein
BPI bactericidal/permeability-increasing protein
C2ORF42 chromosome 2 open reading frame 42
C5ORF30 chromosome 5 open reading frame 30
CDCA3 cell division cycle associated 3
CEPT1 choline/ethanolamine phosphotransferase 1
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIC capicua transcriptional repressor
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CPOX coproporphyrinogen oxidase
CTR9 CTR9, Paf1/RNA polymerase II complex component
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DBR1 debranching RNA lariats 1
DENND4A DENN/MADD domain containing 4A
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
ERCC2 excision repair cross-complementation group 2
FANCL Fanconi anemia, complementation group L
FBXO46 F-box protein 46
FBXW4 F-box and WD repeat domain containing 4
FNDC3B fibronectin type III domain containing 3B
GBAP1 glucosidase, beta, acid pseudogene 1
GPN3 GPN-loop GTPase 3
GPR21 G protein-coupled receptor 21
GRM6 glutamate receptor, metabotropic 6
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HIST1H2BF histone cluster 1, H2bf
HIST2H2BE histone cluster 2, H2be
KAT7 K(lysine) acetyltransferase 7
KRI1 KRI1 homolog (S. cerevisiae)
LINC00339 long intergenic non-protein coding RNA 339
LOC642236 FSHD region gene 1 pseudogene
LRRC37A2 leucine rich repeat containing 37, member A2
LXN latexin
LZTFL1 leucine zipper transcription factor-like 1
MCM9 minichromosome maintenance complex component 9
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTERF1 mitochondrial transcription termination factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NPIPB15 nuclear pore complex interacting protein family, member B15
NSUN3 NOP2/Sun domain family, member 3
OPHN1 oligophrenin 1
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK1IP1 PAK1 interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCTP phosphatidylcholine transfer protein
PDZD8 PDZ domain containing 8
PEMT phosphatidylethanolamine N-methyltransferase
PEX26 peroxisomal biogenesis factor 26
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RBM41 RNA binding motif protein 41
RBM4B RNA binding motif protein 4B
RIC8A RIC8 guanine nucleotide exchange factor A
RPP38 ribonuclease P/MRP 38kDa subunit
SCYL2 SCY1-like 2 (S. cerevisiae)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SNX11 sorting nexin 11
SPX spexin hormone
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN2 tectonic family member 2
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TMEM115 transmembrane protein 115
TMEM168 transmembrane protein 168
TMEM186 transmembrane protein 186
TMEM230 transmembrane protein 230
TMPRSS6 transmembrane protease, serine 6
TRAPPC12 trafficking protein particle complex 12
TRIM21 tripartite motif containing 21
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
TUBA3C tubulin, alpha 3c
UNKL unkempt family zinc finger-like
USB1 U6 snRNA biogenesis 1
WDR41 WD repeat domain 41
WDR46 WD repeat domain 46
WT1-AS WT1 antisense RNA
XAF1 XIAP associated factor 1
YIPF3 Yip1 domain family, member 3
ZCCHC8 zinc finger, CCHC domain containing 8
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF217 zinc finger protein 217