naloxone-5243 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the naloxone-5243 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADAM19 ADAM metallopeptidase domain 19
AIM1L absent in melanoma 1-like
AIM2 absent in melanoma 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP3 aquaporin 3 (Gill blood group)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATAT1 alpha tubulin acetyltransferase 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
C10ORF95 chromosome 10 open reading frame 95
C19ORF73 chromosome 19 open reading frame 73
C7ORF69 chromosome 7 open reading frame 69
CABP2 calcium binding protein 2
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CALML5 calmodulin-like 5
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC40 coiled-coil domain containing 40
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDO1 cysteine dioxygenase type 1
CLTA clathrin, light chain A
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DEFA4 defensin, alpha 4, corticostatin
DGKQ diacylglycerol kinase, theta 110kDa
DICER1 dicer 1, ribonuclease type III
DMPK dystrophia myotonica-protein kinase
DPYS dihydropyrimidinase
EGR1 early growth response 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FASLG Fas ligand (TNF superfamily, member 6)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRMD4B FERM domain containing 4B
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GM2A GM2 ganglioside activator
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GP2 glycoprotein 2 (zymogen granule membrane)
GPR39 G protein-coupled receptor 39
HIST1H2BN histone cluster 1, H2bn
HIST1H3A histone cluster 1, H3a
HLF hepatic leukemia factor
IL2RB interleukin 2 receptor, beta
INPP5J inositol polyphosphate-5-phosphatase J
IRF8 interferon regulatory factor 8
IRS2 insulin receptor substrate 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
IZUMO4 IZUMO family member 4
KLHL22 kelch-like family member 22
KRT19P2 keratin 19 pseudogene 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MAOA monoamine oxidase A
MAP1A microtubule-associated protein 1A
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MARK2 MAP/microtubule affinity-regulating kinase 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NLGN1 neuroligin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFML2A olfactomedin-like 2A
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARD6A par-6 family cell polarity regulator alpha
PDE7B phosphodiesterase 7B
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRPH2 peripherin 2 (retinal degeneration, slow)
RARA retinoic acid receptor, alpha
RGS10 regulator of G-protein signaling 10
RIMS3 regulating synaptic membrane exocytosis 3
RPL35A ribosomal protein L35a
RUNDC3A RUN domain containing 3A
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SBF1 SET binding factor 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SERHL2 serine hydrolase-like 2
SFRP4 secreted frizzled-related protein 4
SIM2 single-minded family bHLH transcription factor 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYN2 synapsin II
SYN3 synapsin III
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCHH trichohyalin
TNC tenascin C
TP63 tumor protein p63
TRAIP TRAF interacting protein
TUBB2B tubulin, beta 2B class IIb
UNC119 unc-119 homolog (C. elegans)
VN1R1 vomeronasal 1 receptor 1
WNT2B wingless-type MMTV integration site family, member 2B
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ANXA2P3 annexin A2 pseudogene 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B9D2 B9 protein domain 2
C1ORF159 chromosome 1 open reading frame 159
C1ORF35 chromosome 1 open reading frame 35
C8ORF60 chromosome 8 open reading frame 60
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC9 coiled-coil domain containing 9
CDK20 cyclin-dependent kinase 20
CLCN6 chloride channel, voltage-sensitive 6
COPZ2 coatomer protein complex, subunit zeta 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSCAM Down syndrome cell adhesion molecule
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ERCC6 excision repair cross-complementation group 6
ETV6 ets variant 6
FAM110B family with sequence similarity 110, member B
FAN1 FANCD2/FANCI-associated nuclease 1
FBRS fibrosin
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GK3P glycerol kinase 3 pseudogene
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR27 G protein-coupled receptor 27
HLA-J major histocompatibility complex, class I, J (pseudogene)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IGFBP6 insulin-like growth factor binding protein 6
IL17RA interleukin 17 receptor A
KCNK12 potassium channel, two pore domain subfamily K, member 12
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
KRT13 keratin 13, type I
LIME1 Lck interacting transmembrane adaptor 1
LOC390998 ribosomal protein L10 pseudogene
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MCOLN1 mucolipin 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP2 matrix metallopeptidase 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPM3 nucleophosmin/nucleoplasmin 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NXPH4 neurexophilin 4
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSGIN1 oxidative stress induced growth inhibitor 1
PCDHA5 protocadherin alpha 5
PCDHA6 protocadherin alpha 6
PLA2G3 phospholipase A2, group III
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHO1 pleckstrin homology domain containing, family O member 1
POMT2 protein-O-mannosyltransferase 2
PRODH proline dehydrogenase (oxidase) 1
RASAL1 RAS protein activator like 1 (GAP1 like)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A7 S100 calcium binding protein A7
SAV1 salvador family WW domain containing protein 1
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SENP7 SUMO1/sentrin specific peptidase 7
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD1A SET domain containing 1A
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLMO1 slowmo homolog 1 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX12 SRY (sex determining region Y)-box 12
ST5 suppression of tumorigenicity 5
STRA6 stimulated by retinoic acid 6
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TESK1 testis-specific kinase 1
THOP1 thimet oligopeptidase 1
TLE2 transducin-like enhancer of split 2
TMEM242 transmembrane protein 242
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRIM25 tripartite motif containing 25
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3D tubulin, alpha 3d
UBOX5 U-box domain containing 5
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
USP6NL USP6 N-terminal like
VPS9D1 VPS9 domain containing 1
WDR25 WD repeat domain 25
WDR62 WD repeat domain 62
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF16 zinc finger protein 16
ZNF492 zinc finger protein 492
ZNF506 zinc finger protein 506