naltrexone-2209 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the naltrexone-2209 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
ADGRL3 adhesion G protein-coupled receptor L3
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKAP11 A kinase (PRKA) anchor protein 11
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APC adenomatous polyposis coli
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BRD7P3 bromodomain containing 7 pseudogene 3
BTN2A1 butyrophilin, subfamily 2, member A1
CALCR calcitonin receptor
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNK cyclin K
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFAP45 cilia and flagella associated protein 45
CFLAR CASP8 and FADD-like apoptosis regulator
COL1A1 collagen, type I, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGCR8 DGCR8 microprocessor complex subunit
DNAH17 dynein, axonemal, heavy chain 17
DOCK6 dedicator of cytokinesis 6
DPY19L1 dpy-19-like 1 (C. elegans)
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
ERCC4 excision repair cross-complementation group 4
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FOXG1 forkhead box G1
FXYD5 FXYD domain containing ion transport regulator 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GUSBP3 glucuronidase, beta pseudogene 3
HBEGF heparin-binding EGF-like growth factor
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
JAM3 junctional adhesion molecule 3
KIAA0125 KIAA0125
KRT83 keratin 83, type II
LAMP1 lysosomal-associated membrane protein 1
LARP7 La ribonucleoprotein domain family, member 7
MED18 mediator complex subunit 18
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKL1 megakaryoblastic leukemia (translocation) 1
NF2 neurofibromin 2 (merlin)
NNMT nicotinamide N-methyltransferase
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPC1 Niemann-Pick disease, type C1
NT5M 5',3'-nucleotidase, mitochondrial
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OGDHL oxoglutarate dehydrogenase-like
ONECUT2 one cut homeobox 2
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PCNX pecanex homolog (Drosophila)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PKD2L2 polycystic kidney disease 2-like 2
PLCD1 phospholipase C, delta 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSG6 pregnancy specific beta-1-glycoprotein 6
RABGAP1L RAB GTPase activating protein 1-like
RB1 retinoblastoma 1
RBM48 RNA binding motif protein 48
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SERHL2 serine hydrolase-like 2
SKIL SKI-like proto-oncogene
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SORT1 sortilin 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPN sialophorin
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
ST20 suppressor of tumorigenicity 20
STK24 serine/threonine kinase 24
SUGP1 SURP and G patch domain containing 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAPBP TAP binding protein (tapasin)
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
USP12 ubiquitin specific peptidase 12
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WAPAL wings apart-like homolog (Drosophila)
WDR55 WD repeat domain 55
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZCCHC14 zinc finger, CCHC domain containing 14
ZMYND8 zinc finger, MYND-type containing 8
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOD apolipoprotein D
ARC activity-regulated cytoskeleton-associated protein
ARRB1 arrestin, beta 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BGLAP bone gamma-carboxyglutamate (gla) protein
C17ORF70 chromosome 17 open reading frame 70
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF54 chromosome 2 open reading frame 54
C7ORF43 chromosome 7 open reading frame 43
CASZ1 castor zinc finger 1
CD79B CD79b molecule, immunoglobulin-associated beta
CDK3 cyclin-dependent kinase 3
CIC capicua transcriptional repressor
CLCN6 chloride channel, voltage-sensitive 6
CORO7 coronin 7
CUZD1 CUB and zona pellucida-like domains 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOK5 docking protein 5
DSPP dentin sialophosphoprotein
DVL1 dishevelled segment polarity protein 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EMID1 EMI domain containing 1
ETNK2 ethanolamine kinase 2
FAM46C family with sequence similarity 46, member C
FFAR2 free fatty acid receptor 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GADD45G growth arrest and DNA-damage-inducible, gamma
GPX2 glutathione peroxidase 2
GRPR gastrin-releasing peptide receptor
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC5 histone deacetylase 5
HIST1H1D histone cluster 1, H1d
HIST1H3B histone cluster 1, H3b
HIST1H4A histone cluster 1, H4a
HOXA4 homeobox A4
IDI2-AS1 IDI2 antisense RNA 1
IQSEC2 IQ motif and Sec7 domain 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LIME1 Lck interacting transmembrane adaptor 1
LYRM9 LYR motif containing 9
MED9 mediator complex subunit 9
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NDE1 nudE neurodevelopment protein 1
NEUROD4 neuronal differentiation 4
NOL10 nucleolar protein 10
NT5DC3 5'-nucleotidase domain containing 3
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G3 phospholipase A2, group III
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PRSS16 protease, serine, 16 (thymus)
PTK6 protein tyrosine kinase 6
RAB3D RAB3D, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS19 regulator of G-protein signaling 19
RNF2 ring finger protein 2
S100A4 S100 calcium binding protein A4
SAYSD1 SAYSVFN motif domain containing 1
SECTM1 secreted and transmembrane 1
SETD1A SET domain containing 1A
SF3A2 splicing factor 3a, subunit 2, 66kDa
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIPA1 signal-induced proliferation-associated 1
SIX1 SIX homeobox 1
SKI SKI proto-oncogene
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPATA2L spermatogenesis associated 2-like
STAG3 stromal antigen 3
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEX40 testis expressed 40
TH tyrosine hydroxylase
TLN1 talin 1
TLR2 toll-like receptor 2
TMLHE trimethyllysine hydroxylase, epsilon
TMPRSS4 transmembrane protease, serine 4
TMUB2 transmembrane and ubiquitin-like domain containing 2
TTBK2 tau tubulin kinase 2
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
VAX2 ventral anterior homeobox 2
WDR76 WD repeat domain 76
WLS wntless Wnt ligand secretion mediator
XDH xanthine dehydrogenase
XYLT2 xylosyltransferase II
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF506 zinc finger protein 506
ZNF574 zinc finger protein 574