naltrexone-5765 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the naltrexone-5765 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAP1 ArfGAP with dual PH domains 1
ADGRB1 adhesion G protein-coupled receptor B1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANXA10 annexin A10
ARHGAP44 Rho GTPase activating protein 44
ARMCX2 armadillo repeat containing, X-linked 2
ARTN artemin
BGN biglycan
BMP2 bone morphogenetic protein 2
BMP2K BMP2 inducible kinase
BMP5 bone morphogenetic protein 5
C3AR1 complement component 3a receptor 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC177 coiled-coil domain containing 177
CFAP69 cilia and flagella associated protein 69
CNPY4 canopy FGF signaling regulator 4
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP3B contactin associated protein-like 3B
COL10A1 collagen, type X, alpha 1
COL15A1 collagen, type XV, alpha 1
CROCC ciliary rootlet coiled-coil, rootletin
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAAM2 dishevelled associated activator of morphogenesis 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DZIP1 DAZ interacting zinc finger protein 1
EDA ectodysplasin A
EDIL3 EGF-like repeats and discoidin I-like domains 3
FABP3 fatty acid binding protein 3, muscle and heart
FGF18 fibroblast growth factor 18
FGFR2 fibroblast growth factor receptor 2
GAS2 growth arrest-specific 2
GMPR guanosine monophosphate reductase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GSTA3 glutathione S-transferase alpha 3
HDAC6 histone deacetylase 6
HLA-DMB major histocompatibility complex, class II, DM beta
HNF4A hepatocyte nuclear factor 4, alpha
HOOK1 hook microtubule-tethering protein 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIF1A kinesin family member 1A
KRT34 keratin 34, type I
LAMB4 laminin, beta 4
LOC79999 uncharacterized LOC79999
LY86 lymphocyte antigen 86
MERTK MER proto-oncogene, tyrosine kinase
MFAP3 microfibrillar-associated protein 3
MUC4 mucin 4, cell surface associated
MYCNOS MYCN opposite strand
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NPC1 Niemann-Pick disease, type C1
OGFR opioid growth factor receptor
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OTUD4 OTU deubiquitinase 4
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAIP2B poly(A) binding protein interacting protein 2B
PAX8 paired box 8
PLA1A phospholipase A1 member A
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
PRDM12 PR domain containing 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RBBP9 retinoblastoma binding protein 9
RBFA ribosome binding factor A (putative)
RCAN2 regulator of calcineurin 2
RHBDD3 rhomboid domain containing 3
SARDH sarcosine dehydrogenase
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SH3BP2 SH3-domain binding protein 2
SLC16A6 solute carrier family 16, member 6
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35F5 solute carrier family 35, member F5
STC1 stanniocalcin 1
STK11 serine/threonine kinase 11
SYNDIG1 synapse differentiation inducing 1
SYNGR3 synaptogyrin 3
TAS2R10 taste receptor, type 2, member 10
TBC1D2B TBC1 domain family, member 2B
TBXA2R thromboxane A2 receptor
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNK2 tyrosine kinase, non-receptor, 2
TUBA3C tubulin, alpha 3c
UNC13A unc-13 homolog A (C. elegans)
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF140 zinc finger protein 140
ZNF224 zinc finger protein 224
ZNF529 zinc finger protein 529

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKRD36 ankyrin repeat domain 36
ARL15 ADP-ribosylation factor-like 15
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAT1 alpha tubulin acetyltransferase 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C16ORF59 chromosome 16 open reading frame 59
C1RL complement component 1, r subcomponent-like
C22ORF29 chromosome 22 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CA5BP1 carbonic anhydrase VB pseudogene 1
CDK3 cyclin-dependent kinase 3
CISH cytokine inducible SH2-containing protein
CLDN11 claudin 11
CLEC16A C-type lectin domain family 16, member A
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBL cordon-bleu WH2 repeat protein
CSF1R colony stimulating factor 1 receptor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DOCK1 dedicator of cytokinesis 1
EDC3 enhancer of mRNA decapping 3
ERCC5 excision repair cross-complementation group 5
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETV4 ets variant 4
EYA4 EYA transcriptional coactivator and phosphatase 4
FBRS fibrosin
FKBP10 FK506 binding protein 10, 65 kDa
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALT galactose-1-phosphate uridylyltransferase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GRTP1 growth hormone regulated TBC protein 1
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HOXC8 homeobox C8
IFNA17 interferon, alpha 17
IL17RB interleukin 17 receptor B
INO80D INO80 complex subunit D
ITK IL2-inducible T-cell kinase
KRT8P12 keratin 8 pseudogene 12
LMO7 LIM domain 7
LOC257152 uncharacterized LOC257152
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYPD3 LY6/PLAUR domain containing 3
MBTD1 mbt domain containing 1
MGC12488
MT1M metallothionein 1M
MYO1D myosin ID
MYO1F myosin IF
NBEAL2 neurobeachin-like 2
NKX3-2 NK3 homeobox 2
NPM3 nucleophosmin/nucleoplasmin 3
NT5DC3 5'-nucleotidase domain containing 3
NT5M 5',3'-nucleotidase, mitochondrial
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR4 progestin and adipoQ receptor family member IV
PC pyruvate carboxylase
PDE12 phosphodiesterase 12
PHEX phosphate regulating endopeptidase homolog, X-linked
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PODXL2 podocalyxin-like 2
POLM polymerase (DNA directed), mu
PRR15L proline rich 15-like
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RNF2 ring finger protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUFY2 RUN and FYVE domain containing 2
S100A3 S100 calcium binding protein A3
SLITRK5 SLIT and NTRK-like family, member 5
SOBP sine oculis binding protein homolog (Drosophila)
SPEG SPEG complex locus
STARD3 StAR-related lipid transfer (START) domain containing 3
STBD1 starch binding domain 1
STK16 serine/threonine kinase 16
TMCC2 transmembrane and coiled-coil domain family 2
TOM1 target of myb1 (chicken)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WDR4 WD repeat domain 4
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB6 zinc finger and BTB domain containing 6
ZNF573 zinc finger protein 573
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768
ZNF862 zinc finger protein 862