nanog_16518401_mesc_lof_mouse_gpl1261_gds1824 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS1824
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Genes

192 genes differentially expressed following the nanog_16518401_mesc_lof_mouse_gpl1261_gds1824 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.408419
FGFBP1 fibroblast growth factor binding protein 1 0.407946
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.407808
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.407266
VGLL3 vestigial-like family member 3 0.407238
H19 H19, imprinted maternally expressed transcript (non-protein coding) 0.407058
IGF2 insulin-like growth factor 2 0.406518
NELFA negative elongation factor complex member A 0.405771
MEP1B meprin A, beta 0.405563
PERP PERP, TP53 apoptosis effector 0.404642
GLRX2 glutaredoxin 2 0.404533
HIST1H2BC histone cluster 1, H2bc 0.404151
LXN latexin 0.403592
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.402571
HSPA1B heat shock 70kDa protein 1B 0.401527
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.39953
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 0.397656
GJA1 gap junction protein, alpha 1, 43kDa 0.395315
SCAMP1 secretory carrier membrane protein 1 0.393887
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.392826
CWC22 CWC22 spliceosome-associated protein 0.390584
RPL13 ribosomal protein L13 0.38522
FLNB filamin B, beta 0.384998
CALCOCO2 calcium binding and coiled-coil domain 2 0.382661
SPESP1 sperm equatorial segment protein 1 0.379549
CA2 carbonic anhydrase II 0.375664
CSRNP1 cysteine-serine-rich nuclear protein 1 0.374819
S100A6 S100 calcium binding protein A6 0.369804
LGALS1 lectin, galactoside-binding, soluble, 1 0.369098
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.365976
LPAR6 lysophosphatidic acid receptor 6 0.355165
ZNF560 zinc finger protein 560 0.353378
IGFBP3 insulin-like growth factor binding protein 3 0.349034
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.334948
SFMBT2 Scm-like with four mbt domains 2 0.331161
AMOTL2 angiomotin like 2 0.329811
FAT1 FAT atypical cadherin 1 0.329641
FGF1 fibroblast growth factor 1 (acidic) 0.327045
NODAL nodal growth differentiation factor 0.323173
KRT18 keratin 18, type I 0.317015
PMM2 phosphomannomutase 2 0.309202
ADRB3 adrenoceptor beta 3 0.30056
LONP2 lon peptidase 2, peroxisomal 0.29212
EFNB2 ephrin-B2 0.27758
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.26106
THBS1 thrombospondin 1 0.25894
ANXA3 annexin A3 0.227957
DDIT4L DNA-damage-inducible transcript 4-like 0.226951
ZFAND2A zinc finger, AN1-type domain 2A 0.219128
CYR61 cysteine-rich, angiogenic inducer, 61 0.212622
KRTAP4-9 keratin associated protein 4-9 0.177549
DST dystonin 0.175094
SS18 synovial sarcoma translocation, chromosome 18 0.167837
ETL4 epilepsy, occipitotemporal lobe, and migraine with aura 0.159081
CAPN2 calpain 2, (m/II) large subunit 0.134909
PLAGL1 pleiomorphic adenoma gene-like 1 0.104045
ZWINT ZW10 interacting kinetochore protein 0.096512
COCH cochlin 0.088988
FUNDC1 FUN14 domain containing 1 0.083828
UBC ubiquitin C 0.082475
ARG2 arginase 2 0.081996
REXO2 RNA exonuclease 2 0.06359
IRGM immunity-related GTPase family, M 0.055443
PDGFRL platelet-derived growth factor receptor-like 0.054172
PPAP2B phosphatidic acid phosphatase type 2B 0.045877
FBP2 fructose-1,6-bisphosphatase 2 0.036182
PLK3 polo-like kinase 3 0.025588
CCNO cyclin O 0.012261

decreased expression

Symbol Name Standardized Value
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.80977
H1F0 H1 histone family, member 0 -2.79918
KDM5B lysine (K)-specific demethylase 5B -2.79777
NANOG Nanog homeobox -2.78706
MARCKS myristoylated alanine-rich protein kinase C substrate -2.78669
ESRRB estrogen-related receptor beta -2.78578
KAT6B K(lysine) acetyltransferase 6B -2.78286
NAMPT nicotinamide phosphoribosyltransferase -2.77843
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.77448
FIGNL1 fidgetin-like 1 -2.76485
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.75944
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -2.7188
EGR1 early growth response 1 -2.67205
FYTTD1 forty-two-three domain containing 1 -2.64566
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -2.64288
FXYD6 FXYD domain containing ion transport regulator 6 -2.61343
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.59624
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.57757
FBLIM1 filamin binding LIM protein 1 -2.57638
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 -2.53886
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -2.52543
IFT43 intraflagellar transport 43 -2.49374
CDYL2 chromodomain protein, Y-like 2 -2.40491
KIAA0101 KIAA0101 -2.34068
HSF2BP heat shock transcription factor 2 binding protein -2.26512
FZD5 frizzled class receptor 5 -2.26383
PLA2G10 phospholipase A2, group X -2.22793
ZIC5 Zic family member 5 -2.20127
MID1 midline 1 -2.16551
A2M alpha-2-macroglobulin -2.16359
LRRC2 leucine rich repeat containing 2 -2.15328
TCL1A T-cell leukemia/lymphoma 1A -2.13546
MUT methylmalonyl CoA mutase -2.08676
PFKP phosphofructokinase, platelet -2.07561
COMMD1 copper metabolism (Murr1) domain containing 1 -2.06537
TPI1 triosephosphate isomerase 1 -2.06454
GLI2 GLI family zinc finger 2 -2.05469
FAM60A family with sequence similarity 60, member A -2.01962
LRRC34 leucine rich repeat containing 34 -1.99533
FKBP3 FK506 binding protein 3, 25kDa -1.98528
TTI1 TELO2 interacting protein 1 -1.8892
PRELID2 PRELI domain containing 2 -1.85097
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -1.80923
ERAS ES cell expressed Ras -1.68731
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -1.48726
IFITM3 interferon induced transmembrane protein 3 -1.40167
MANBA mannosidase, beta A, lysosomal -1.37133
PHGDH phosphoglycerate dehydrogenase -1.35861
IER3 immediate early response 3 -1.15243
BHLHE40 basic helix-loop-helix family, member e40 -1.06657
EIF1AX eukaryotic translation initiation factor 1A, X-linked -0.879029
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.848989
SYCE2 synaptonemal complex central element protein 2 -0.72496
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.585073
HCK HCK proto-oncogene, Src family tyrosine kinase -0.578584
PAX6 paired box 6 -0.575314
TUBA3E tubulin, alpha 3e -0.551173
NR0B1 nuclear receptor subfamily 0, group B, member 1 -0.47009
CSNK1A1 casein kinase 1, alpha 1 -0.432678
PSIP1 PC4 and SFRS1 interacting protein 1 -0.413057
RFC4 replication factor C (activator 1) 4, 37kDa -0.386872
LDHB lactate dehydrogenase B -0.386326
IFITM2 interferon induced transmembrane protein 2 -0.386126
TMED7 transmembrane emp24 protein transport domain containing 7 -0.385148
TUBB2B tubulin, beta 2B class IIb -0.384989
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.384776
INHBB inhibin, beta B -0.384524
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.384451
SMC1B structural maintenance of chromosomes 1B -0.384388
ARMCX2 armadillo repeat containing, X-linked 2 -0.383939
GCAT glycine C-acetyltransferase -0.38344
SWI5 SWI5 recombination repair homolog (yeast) -0.383415
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -0.383036
PNO1 partner of NOB1 homolog (S. cerevisiae) -0.382928
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.381934
LCK LCK proto-oncogene, Src family tyrosine kinase -0.381848
GLTSCR1L GLTSCR1-like -0.381704
OSBPL1A oxysterol binding protein-like 1A -0.381638
JAM2 junctional adhesion molecule 2 -0.381312
CCND1 cyclin D1 -0.381169
NFYB nuclear transcription factor Y, beta -0.380559
N4BP3 NEDD4 binding protein 3 -0.380496
TMSB10 thymosin beta 10 -0.380218
OOEP oocyte expressed protein -0.378858
PNMA2 paraneoplastic Ma antigen 2 -0.378463
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -0.377972
NADK2 NAD kinase 2, mitochondrial -0.376245
UNKL unkempt family zinc finger-like -0.37065
NEFM neurofilament, medium polypeptide -0.360666
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -0.350757
EIF4H eukaryotic translation initiation factor 4H -0.313424
GLUD1 glutamate dehydrogenase 1 -0.303402
PSRC1 proline/serine-rich coiled-coil 1 -0.287727
GPN3 GPN-loop GTPase 3 -0.285862
CCNG1 cyclin G1 -0.27948
MBNL2 muscleblind-like splicing regulator 2 -0.272093
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.261387
GLIS2 GLIS family zinc finger 2 -0.240329
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -0.229546
HMGXB4 HMG box domain containing 4 -0.212031
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -0.195017
SEPP1 selenoprotein P, plasma, 1 -0.193315
SGCE sarcoglycan, epsilon -0.18898
HMGA2 high mobility group AT-hook 2 -0.174627
KLF3 Kruppel-like factor 3 (basic) -0.1674
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -0.154852
MBNL3 muscleblind-like splicing regulator 3 -0.149102
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.137542
TTC30B tetratricopeptide repeat domain 30B -0.137195
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 -0.135776
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.134592
PEG3 paternally expressed 3 -0.118921
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -0.115182
KCMF1 potassium channel modulatory factor 1 -0.112729
VIMP VCP-interacting membrane selenoprotein -0.109152
CCSER1 coiled-coil serine-rich protein 1 -0.099543
SPTA1 spectrin, alpha, erythrocytic 1 -0.095254
S100A10 S100 calcium binding protein A10 -0.062049
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.050546
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -0.050085
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -0.036465
HMOX1 heme oxygenase 1 -0.018265
HMGN5 high mobility group nucleosome binding domain 5 -0.013389
LPAR4 lysophosphatidic acid receptor 4 -0.003714
Funding