napelline-4486 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the napelline-4486 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACE2 angiotensin I converting enzyme 2
AGGF1 angiogenic factor with G patch and FHA domains 1
ALDOB aldolase B, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANGPTL4 angiopoietin-like 4
APC2 adenomatosis polyposis coli 2
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATXN2L ataxin 2-like
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C11ORF21 chromosome 11 open reading frame 21
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK13 cyclin-dependent kinase 13
CHN2 chimerin 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLSTN3 calsyntenin 3
CLTA clathrin, light chain A
CSF1 colony stimulating factor 1 (macrophage)
DCN decorin
DGCR2 DiGeorge syndrome critical region gene 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMPK dystrophia myotonica-protein kinase
DSTYK dual serine/threonine and tyrosine protein kinase
ECE1 endothelin converting enzyme 1
EGR2 early growth response 2
EPHA5 EPH receptor A5
EPN1 epsin 1
ETV1 ets variant 1
FAM63B family with sequence similarity 63, member B
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FHL3 four and a half LIM domains 3
FSCN3 fascin actin-bundling protein 3, testicular
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GLB1L galactosidase, beta 1-like
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIP2 glutamate receptor interacting protein 2
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IGSF6 immunoglobulin superfamily, member 6
IL1A interleukin 1, alpha
ITGA7 integrin, alpha 7
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
ITGB6 integrin, beta 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK5 potassium channel, two pore domain subfamily K, member 5
KEL Kell blood group, metallo-endopeptidase
KIAA0319L KIAA0319-like
KLHL25 kelch-like family member 25
LAMC3 laminin, gamma 3
LRP2 low density lipoprotein receptor-related protein 2
MAGEA12 melanoma antigen family A12
MVB12B multivesicular body subunit 12B
NLE1 notchless homolog 1 (Drosophila)
NOVA2 neuro-oncological ventral antigen 2
NRP2 neuropilin 2
PDLIM5 PDZ and LIM domain 5
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTCRA pre T-cell antigen receptor alpha
RAB40AL RAB40A, member RAS oncogene family-like
RAB6A RAB6A, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RARA retinoic acid receptor, alpha
REEP1 receptor accessory protein 1
RGS5 regulator of G-protein signaling 5
RUNDC3A RUN domain containing 3A
SBNO1 strawberry notch homolog 1 (Drosophila)
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFTPB surfactant protein B
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SNRPN small nuclear ribonucleoprotein polypeptide N
STOML1 stomatin (EPB72)-like 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D2 TBC1 domain family, member 2
TCP10 t-complex 10
TFDP3 transcription factor Dp family, member 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS15 transmembrane protease, serine 15
TNPO2 transportin 2
UBA6 ubiquitin-like modifier activating enzyme 6
UBE2I ubiquitin-conjugating enzyme E2I
WDR59 WD repeat domain 59
WIZ widely interspaced zinc finger motifs
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AADAC arylacetamide deacetylase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACBD4 acyl-CoA binding domain containing 4
ADGRB2 adhesion G protein-coupled receptor B2
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANXA2P1 annexin A2 pseudogene 1
ATAD5 ATPase family, AAA domain containing 5
ATG10 autophagy related 10
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
AURKC aurora kinase C
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX1 brain expressed, X-linked 1
BICC1 BicC family RNA binding protein 1
BSPRY B-box and SPRY domain containing
BTF3P12 basic transcription factor 3 pseudogene 12
CA5BP1 carbonic anhydrase VB pseudogene 1
CALCOCO1 calcium binding and coiled-coil domain 1
CAMKMT calmodulin-lysine N-methyltransferase
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCL27 chemokine (C-C motif) ligand 27
CD101 CD101 molecule
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DCAF17 DDB1 and CUL4 associated factor 17
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOC2A double C2-like domains, alpha
DPF3 D4, zinc and double PHD fingers, family 3
EGF epidermal growth factor
FAIM Fas apoptotic inhibitory molecule
FAM204A family with sequence similarity 204, member A
FANCE Fanconi anemia, complementation group E
FBRS fibrosin
FBXO2 F-box protein 2
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HIST1H2BM histone cluster 1, H2bm
HIST1H3C histone cluster 1, H3c
HIST1H4C histone cluster 1, H4c
HOXA2 homeobox A2
HOXA4 homeobox A4
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFI6 interferon, alpha-inducible protein 6
INO80D INO80 complex subunit D
ITPKA inositol-trisphosphate 3-kinase A
KIAA0232 KIAA0232
KLHL36 kelch-like family member 36
LMTK1 lemur tail kinase 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRK1 leucine-rich repeat kinase 1
LY86 lymphocyte antigen 86
MDFI MyoD family inhibitor
MFAP2 microfibrillar-associated protein 2
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MMP2 matrix metallopeptidase 2
MNX1 motor neuron and pancreas homeobox 1
MVP major vault protein
NARFL nuclear prelamin A recognition factor-like
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCDHA9 protocadherin alpha 9
PID1 phosphotyrosine interaction domain containing 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLL polymerase (DNA directed), lambda
PTPRE protein tyrosine phosphatase, receptor type, E
RNF25 ring finger protein 25
RPP25 ribonuclease P/MRP 25kDa subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SELL selectin L
SERTAD3 SERTA domain containing 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
SPATA2L spermatogenesis associated 2-like
STON1 stonin 1
TIGD6 tigger transposable element derived 6
TNRC6B trinucleotide repeat containing 6B
TRABD TraB domain containing
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR25 WD repeat domain 25
XAB2 XPA binding protein 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF134 zinc finger protein 134
ZNF37BP zinc finger protein 37B, pseudogene
ZNF573 zinc finger protein 573
ZNF668 zinc finger protein 668
ZNF816 zinc finger protein 816