naproxen-2533 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the naproxen-2533 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTC1 actin, alpha, cardiac muscle 1
AHCYL2 adenosylhomocysteinase-like 2
ALOXE3 arachidonate lipoxygenase 3
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARNT aryl hydrocarbon receptor nuclear translocator
ASB9 ankyrin repeat and SOCS box containing 9
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP7B ATPase, Cu++ transporting, beta polypeptide
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP8B bone morphogenetic protein 8b
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCSER2 coiled-coil serine-rich protein 2
CDC14B cell division cycle 14B
CDO1 cysteine dioxygenase type 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEND1 cell cycle exit and neuronal differentiation 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRY2 cryptochrome circadian clock 2
CTAGE9 CTAGE family, member 9
EFNB2 ephrin-B2
EIF1 eukaryotic translation initiation factor 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM155A family with sequence similarity 155, member A
FCAR Fc fragment of IgA receptor
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FST follistatin
GAS6 growth arrest-specific 6
GDAP1 ganglioside induced differentiation associated protein 1
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GK glycerol kinase
GRHL2 grainyhead-like 2 (Drosophila)
HIPK3 homeodomain interacting protein kinase 3
HOXA4 homeobox A4
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICAM1 intercellular adhesion molecule 1
KCTD20 potassium channel tetramerization domain containing 20
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF12 Kruppel-like factor 12
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRIT1 KRIT1, ankyrin repeat containing
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LEPR leptin receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LPAR1 lysophosphatidic acid receptor 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP7 microtubule-associated protein 7
MMP3 matrix metallopeptidase 3
MORN1 MORN repeat containing 1
MSRB2 methionine sulfoxide reductase B2
MTMR8 myotubularin related protein 8
MYRF myelin regulatory factor
NCKAP1L NCK-associated protein 1-like
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDHA9 protocadherin alpha 9
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDLIM7 PDZ and LIM domain 7 (enigma)
PEX26 peroxisomal biogenesis factor 26
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLCG1 phospholipase C, gamma 1
PLK4 polo-like kinase 4
PORCN porcupine homolog (Drosophila)
POU4F1 POU class 4 homeobox 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKCE protein kinase C, epsilon
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVR poliovirus receptor
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
REEP1 receptor accessory protein 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHOD ras homolog family member D
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
STARD5 StAR-related lipid transfer (START) domain containing 5
STRA6 stimulated by retinoic acid 6
SUGP1 SURP and G patch domain containing 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM242 transmembrane protein 242
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TYMP thymidine phosphorylase
UBTD1 ubiquitin domain containing 1
VPRBP Vpr (HIV-1) binding protein
WDR76 WD repeat domain 76
ZNF185 zinc finger protein 185 (LIM domain)
ZNF205 zinc finger protein 205
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ANKRD36 ankyrin repeat domain 36
ANKRD40 ankyrin repeat domain 40
ANKRD55 ankyrin repeat domain 55
ANXA3 annexin A3
ARG1 arginase 1
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATAT1 alpha tubulin acetyltransferase 1
AXIN1 axin 1
BATF basic leucine zipper transcription factor, ATF-like
BTF3P12 basic transcription factor 3 pseudogene 12
C22ORF46 chromosome 22 open reading frame 46
C5 complement component 5
CCDC176 coiled-coil domain containing 176
CCNB1 cyclin B1
CD70 CD70 molecule
CDC20 cell division cycle 20
CDKL3 cyclin-dependent kinase-like 3
CENPE centromere protein E, 312kDa
CHML choroideremia-like (Rab escort protein 2)
CHMP7 charged multivesicular body protein 7
CLEC2D C-type lectin domain family 2, member D
CORT cortistatin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CXORF56 chromosome X open reading frame 56
DEPDC1 DEP domain containing 1
DOK3 docking protein 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENO3 enolase 3 (beta, muscle)
FJX1 four jointed box 1 (Drosophila)
FLCN folliculin
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
GAB2 GRB2-associated binding protein 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GALE UDP-galactose-4-epimerase
GALK1 galactokinase 1
GRAMD1B GRAM domain containing 1B
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1T histone cluster 1, H1t
HIST1H2BN histone cluster 1, H2bn
HIST1H3B histone cluster 1, H3b
HSPA1L heat shock 70kDa protein 1-like
HSPB6 heat shock protein, alpha-crystallin-related, B6
HYAL3 hyaluronoglucosaminidase 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT81 intraflagellar transport 81
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA0319L KIAA0319-like
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF3B kinesin family member 3B
KLF1 Kruppel-like factor 1 (erythroid)
KRI1 KRI1 homolog (S. cerevisiae)
KRT81 keratin 81, type II
LIME1 Lck interacting transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
MBTD1 mbt domain containing 1
MEGF8 multiple EGF-like-domains 8
MTSS1L metastasis suppressor 1-like
NAG18 NAG18 mRNA
NNAT neuronatin
NXF2 nuclear RNA export factor 2
PADI2 peptidyl arginine deiminase, type II
PIP prolactin-induced protein
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLK1 polo-like kinase 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSKH1 protein serine kinase H1
PSRC1 proline/serine-rich coiled-coil 1
RAB3A RAB3A, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SCAI suppressor of cancer cell invasion
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SNHG20 small nucleolar RNA host gene 20
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRD5A3 steroid 5 alpha-reductase 3
TESK1 testis-specific kinase 1
THEM6 thioesterase superfamily member 6
TNS2 tensin 2
VANGL1 VANGL planar cell polarity protein 1
VEGFC vascular endothelial growth factor C
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB48 zinc finger and BTB domain containing 48
ZNF197 zinc finger protein 197
ZNF551 zinc finger protein 551
ZNF668 zinc finger protein 668
ZNF701 zinc finger protein 701