naproxen-6358 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the naproxen-6358 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACVR1B activin A receptor, type IB
ADGRL1 adhesion G protein-coupled receptor L1
AIM1L absent in melanoma 1-like
ANKLE2 ankyrin repeat and LEM domain containing 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
BBC3 BCL2 binding component 3
C9ORF40 chromosome 9 open reading frame 40
CALD1 caldesmon 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP45 cilia and flagella associated protein 45
CLCA1 chloride channel accessory 1
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNGB3 cyclic nucleotide gated channel beta 3
CSNK1E casein kinase 1, epsilon
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
ELMO2 engulfment and cell motility 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EXD3 exonuclease 3'-5' domain containing 3
FAM13A family with sequence similarity 13, member A
FGF1 fibroblast growth factor 1 (acidic)
FGFR1 fibroblast growth factor receptor 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GIF gastric intrinsic factor (vitamin B synthesis)
GPATCH3 G patch domain containing 3
GPR137 G protein-coupled receptor 137
GPR17 G protein-coupled receptor 17
GPR182 G protein-coupled receptor 182
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H1D histone cluster 1, H1d
IDS iduronate 2-sulfatase
IFNA14 interferon, alpha 14
IL15 interleukin 15
IL17RB interleukin 17 receptor B
INADL InaD-like (Drosophila)
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ISL1 ISL LIM homeobox 1
KDM4C lysine (K)-specific demethylase 4C
KDM6B lysine (K)-specific demethylase 6B
KIAA1109 KIAA1109
KIFC3 kinesin family member C3
LAMA4 laminin, alpha 4
LIMK1 LIM domain kinase 1
LINS lines homolog (Drosophila)
MAPK11 mitogen-activated protein kinase 11
MAPK7 mitogen-activated protein kinase 7
MED9 mediator complex subunit 9
MINK1 misshapen-like kinase 1
MTAP methylthioadenosine phosphorylase
MUC3A mucin 3A, cell surface associated
MYO1F myosin IF
MYOF myoferlin
NDP Norrie disease (pseudoglioma)
NEK1 NIMA-related kinase 1
NIPAL2 NIPA-like domain containing 2
NT5M 5',3'-nucleotidase, mitochondrial
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUMA1 nuclear mitotic apparatus protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF3 polycomb group ring finger 3
PDCD2 programmed cell death 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PEX6 peroxisomal biogenesis factor 6
PLEKHA6 pleckstrin homology domain containing, family A member 6
PMFBP1 polyamine modulated factor 1 binding protein 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PROX1 prospero homeobox 1
PRR7 proline rich 7 (synaptic)
PURA purine-rich element binding protein A
RAD51 RAD51 recombinase
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPL31 ribosomal protein L31
RPS28 ribosomal protein S28
RUNX1 runt-related transcription factor 1
SAFB2 scaffold attachment factor B2
SAYSD1 SAYSVFN motif domain containing 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOGA1 suppressor of glucose, autophagy associated 1
SOX15 SRY (sex determining region Y)-box 15
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRD5A3 steroid 5 alpha-reductase 3
SRSF1 serine/arginine-rich splicing factor 1
SS18 synovial sarcoma translocation, chromosome 18
STK16 serine/threonine kinase 16
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBCD tubulin folding cofactor D
TDRD3 tudor domain containing 3
TLR2 toll-like receptor 2
USB1 U6 snRNA biogenesis 1
VWA1 von Willebrand factor A domain containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF446 zinc finger protein 446
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABHD4 abhydrolase domain containing 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADTRP androgen-dependent TFPI-regulating protein
AFAP1 actin filament associated protein 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ANKRD40 ankyrin repeat domain 40
ANOS1 anosmin 1
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARL15 ADP-ribosylation factor-like 15
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX1 brain expressed, X-linked 1
C11ORF30 chromosome 11 open reading frame 30
C1QTNF1 C1q and tumor necrosis factor related protein 1
C7ORF69 chromosome 7 open reading frame 69
CAPN5 calpain 5
CBX7 chromobox homolog 7
CCDC85C coiled-coil domain containing 85C
CENPO centromere protein O
CENPT centromere protein T
CTSF cathepsin F
CXCL3 chemokine (C-X-C motif) ligand 3
DDN dendrin
DSCAM Down syndrome cell adhesion molecule
EHD3 EH-domain containing 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETNK2 ethanolamine kinase 2
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FER fer (fps/fes related) tyrosine kinase
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLT8D2 glycosyltransferase 8 domain containing 2
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HIST1H2BI histone cluster 1, H2bi
HOMER2 homer scaffolding protein 2
HOXA6 homeobox A6
HOXA7 homeobox A7
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL7R interleukin 7 receptor
ITGA10 integrin, alpha 10
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
LIMS2 LIM and senescent cell antigen-like domains 2
LPAR6 lysophosphatidic acid receptor 6
LZTR1 leucine-zipper-like transcription regulator 1
MAP7D1 MAP7 domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MNX1 motor neuron and pancreas homeobox 1
MTRF1 mitochondrial translational release factor 1
MX1 MX dynamin-like GTPase 1
MYOZ3 myozenin 3
NDRG4 NDRG family member 4
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NXPE3 neurexophilin and PC-esterase domain family, member 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PADI1 peptidyl arginine deiminase, type I
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLD3 phospholipase D family, member 3
POMT2 protein-O-mannosyltransferase 2
RANBP17 RAN binding protein 17
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCG2 secretogranin II
SCML2 sex comb on midleg-like 2 (Drosophila)
SH3GLB2 SH3-domain GRB2-like endophilin B2
SHROOM2 shroom family member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLMO1 slowmo homolog 1 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSBP3 single stranded DNA binding protein 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SYCP2 synaptonemal complex protein 2
TEP1 telomerase-associated protein 1
TLN1 talin 1
TMC5 transmembrane channel-like 5
TMEM120B transmembrane protein 120B
TMEM159 transmembrane protein 159
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM21 tripartite motif containing 21
TSC22D4 TSC22 domain family, member 4
TSKU tsukushi, small leucine rich proteoglycan
URGCP upregulator of cell proliferation
URM1 ubiquitin related modifier 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WNT7A wingless-type MMTV integration site family, member 7A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF324 zinc finger protein 324
ZNF408 zinc finger protein 408
ZNF528 zinc finger protein 528
ZNF606 zinc finger protein 606