naproxen-6794 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the naproxen-6794 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
ANAPC13 anaphase promoting complex subunit 13
APOM apolipoprotein M
BBS9 Bardet-Biedl syndrome 9
C14ORF79 chromosome 14 open reading frame 79
C17ORF59 chromosome 17 open reading frame 59
C1ORF105 chromosome 1 open reading frame 105
CA4 carbonic anhydrase IV
CACFD1 calcium channel flower domain containing 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CHKB choline kinase beta
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CPB1 carboxypeptidase B1 (tissue)
CTC1 CTS telomere maintenance complex component 1
CXCR4 chemokine (C-X-C motif) receptor 4
DCTN1 dynactin 1
DGCR8 DGCR8 microprocessor complex subunit
DLK2 delta-like 2 homolog (Drosophila)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EFNB3 ephrin-B3
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
ETNK2 ethanolamine kinase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FANCA Fanconi anemia, complementation group A
FOXN2 forkhead box N2
FSCN1 fascin actin-bundling protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GSTTP1 glutathione S-transferase theta pseudogene 1
HAO2 hydroxyacid oxidase 2 (long chain)
HFE hemochromatosis
HPS1 Hermansky-Pudlak syndrome 1
HSF1 heat shock transcription factor 1
IL1B interleukin 1, beta
IMPG2 interphotoreceptor matrix proteoglycan 2
IRF4 interferon regulatory factor 4
JAKMIP2 janus kinase and microtubule interacting protein 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLHL22 kelch-like family member 22
KREMEN2 kringle containing transmembrane protein 2
KRT16 keratin 16, type I
KRT83 keratin 83, type II
LTBP2 latent transforming growth factor beta binding protein 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MBD3 methyl-CpG binding domain protein 3
MMP3 matrix metallopeptidase 3
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NAT6 N-acetyltransferase 6 (GCN5-related)
NLGN1 neuroligin 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSGIN2 oxidative stress induced growth inhibitor family member 2
PARD6A par-6 family cell polarity regulator alpha
PCNX pecanex homolog (Drosophila)
PDLIM3 PDZ and LIM domain 3
PER3 period circadian clock 3
PGAP1 post-GPI attachment to proteins 1
PGR progesterone receptor
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLIN2 perilipin 2
PML promyelocytic leukemia
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PSD4 pleckstrin and Sec7 domain containing 4
RFPL3 ret finger protein-like 3
RPLP2 ribosomal protein, large, P2
SAYSD1 SAYSVFN motif domain containing 1
SETD4 SET domain containing 4
SH3GL3 SH3-domain GRB2-like 3
SHOX2 short stature homeobox 2
SIRT5 sirtuin 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
STK24 serine/threonine kinase 24
TGM2 transglutaminase 2
TJAP1 tight junction associated protein 1 (peripheral)
TOP3A topoisomerase (DNA) III alpha
TSGA10 testis specific, 10
TUBB2B tubulin, beta 2B class IIb
TYRP1 tyrosinase-related protein 1
VPS9D1 VPS9 domain containing 1
WDR1 WD repeat domain 1
WDR19 WD repeat domain 19
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WSCD1 WSC domain containing 1
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACSF2 acyl-CoA synthetase family member 2
ACVR2B activin A receptor, type IIB
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AUTS2 autism susceptibility candidate 2
BAX BCL2-associated X protein
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
C22ORF46 chromosome 22 open reading frame 46
CALCOCO1 calcium binding and coiled-coil domain 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC134 coiled-coil domain containing 134
CD82 CD82 molecule
CDKL3 cyclin-dependent kinase-like 3
CEP72 centrosomal protein 72kDa
CGA glycoprotein hormones, alpha polypeptide
CIDEC cell death-inducing DFFA-like effector c
CNPY3 canopy FGF signaling regulator 3
COPS7B COP9 signalosome subunit 7B
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSF cathepsin F
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGAT1 diacylglycerol O-acyltransferase 1
DOCK1 dedicator of cytokinesis 1
DSCAM Down syndrome cell adhesion molecule
DSPP dentin sialophosphoprotein
DVL1 dishevelled segment polarity protein 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPPK1 epiplakin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FGF23 fibroblast growth factor 23
GAMT guanidinoacetate N-methyltransferase
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1D histone cluster 1, H1d
HIST1H2AL histone cluster 1, H2al
HOOK1 hook microtubule-tethering protein 1
HPN hepsin
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IRF1 interferon regulatory factor 1
KDM8 lysine (K)-specific demethylase 8
KIF13B kinesin family member 13B
KLHL36 kelch-like family member 36
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
LIME1 Lck interacting transmembrane adaptor 1
MATK megakaryocyte-associated tyrosine kinase
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
MGC12488
MYL5 myosin, light chain 5, regulatory
NNAT neuronatin
ONECUT2 one cut homeobox 2
PADI1 peptidyl arginine deiminase, type I
PCDH12 protocadherin 12
PCSK7 proprotein convertase subtilisin/kexin type 7
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRB paired immunoglobin-like type 2 receptor beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PTPRU protein tyrosine phosphatase, receptor type, U
QPCTL glutaminyl-peptide cyclotransferase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RGS2 regulator of G-protein signaling 2
RHBDD3 rhomboid domain containing 3
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPAP2 RNA polymerase II associated protein 2
SLIT2 slit homolog 2 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SREK1IP1 SREK1-interacting protein 1
STMN3 stathmin-like 3
TCHH trichohyalin
TMEM180 transmembrane protein 180
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTBK2 tau tubulin kinase 2
UNC119 unc-119 homolog (C. elegans)
USP36 ubiquitin specific peptidase 36
VEZT vezatin, adherens junctions transmembrane protein
WDR76 WD repeat domain 76
YY2 YY2 transcription factor
ZNF227 zinc finger protein 227
ZNF276 zinc finger protein 276
ZNF286A zinc finger protein 286A
ZNF365 zinc finger protein 365
ZNF480 zinc finger protein 480
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747