naproxen-7146 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the naproxen-7146 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1D adrenoceptor alpha 1D
AFAP1 actin filament associated protein 1
AK1 adenylate kinase 1
ALS2CL ALS2 C-terminal like
AMBRA1 autophagy/beclin-1 regulator 1
AMPD3 adenosine monophosphate deaminase 3
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
APOL6 apolipoprotein L, 6
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ATP11A ATPase, class VI, type 11A
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BOLA1 bolA family member 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BSPRY B-box and SPRY domain containing
CABIN1 calcineurin binding protein 1
CCP110 centriolar coiled coil protein 110kDa
CDK3 cyclin-dependent kinase 3
CEMIP cell migration inducing protein, hyaluronan binding
CHAT choline O-acetyltransferase
CREB5 cAMP responsive element binding protein 5
CST1 cystatin SN
DGKE diacylglycerol kinase, epsilon 64kDa
DGKQ diacylglycerol kinase, theta 110kDa
DNPEP aspartyl aminopeptidase
DXO decapping exoribonuclease
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
FAM160B2 family with sequence similarity 160, member B2
FGFR4 fibroblast growth factor receptor 4
FLJ21369 uncharacterized protein FLJ21369
FOSL2 FOS-like antigen 2
FUZ fuzzy planar cell polarity protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GK glycerol kinase
GPR137 G protein-coupled receptor 137
GSTA1 glutathione S-transferase alpha 1
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HR hair growth associated
HYAL3 hyaluronoglucosaminidase 3
IFIH1 interferon induced with helicase C domain 1
ITGB4 integrin, beta 4
ITPKC inositol-trisphosphate 3-kinase C
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KDM5C lysine (K)-specific demethylase 5C
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MECP2 methyl CpG binding protein 2
MED16 mediator complex subunit 16
MFN2 mitofusin 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKL1 megakaryoblastic leukemia (translocation) 1
MOXD1 monooxygenase, DBH-like 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAG18 NAG18 mRNA
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUMA1 nuclear mitotic apparatus protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHKA2 phosphorylase kinase, alpha 2 (liver)
PLD1 phospholipase D1, phosphatidylcholine-specific
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PPP5C protein phosphatase 5, catalytic subunit
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RUNX3 runt-related transcription factor 3
SCARA3 scavenger receptor class A, member 3
SCIN scinderin
SH2D3A SH2 domain containing 3A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMG7 SMG7 nonsense mediated mRNA decay factor
SPATA1 spermatogenesis associated 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SSH3 slingshot protein phosphatase 3
STRN striatin, calmodulin binding protein
SUGP1 SURP and G patch domain containing 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBXAS1 thromboxane A synthase 1 (platelet)
TCP11 t-complex 11, testis-specific
TELO2 telomere maintenance 2
TH tyrosine hydroxylase
TMEM8B transmembrane protein 8B
USP20 ubiquitin specific peptidase 20
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WDR4 WD repeat domain 4
ZNF571 zinc finger protein 571

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTSL3 ADAMTS-like 3
ADGRF1 adhesion G protein-coupled receptor F1
ANOS1 anosmin 1
ANXA10 annexin A10
ARMC6 armadillo repeat containing 6
ASB13 ankyrin repeat and SOCS box containing 13
BAHD1 bromo adjacent homology domain containing 1
BCL2L2 BCL2-like 2
BIRC3 baculoviral IAP repeat containing 3
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
C17ORF85 chromosome 17 open reading frame 85
C3ORF52 chromosome 3 open reading frame 52
C9ORF91 chromosome 9 open reading frame 91
CCNA1 cyclin A1
CLDN7 claudin 7
CRIP1 cysteine-rich protein 1 (intestinal)
DHRS11 dehydrogenase/reductase (SDR family) member 11
EFCAB2 EF-hand calcium binding domain 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
F8 coagulation factor VIII, procoagulant component
FAM114A2 family with sequence similarity 114, member A2
FAM131A family with sequence similarity 131, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FHOD1 formin homology 2 domain containing 1
GHR growth hormone receptor
GRHL2 grainyhead-like 2 (Drosophila)
GRWD1 glutamate-rich WD repeat containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC9 histone deacetylase 9
HIRA histone cell cycle regulator
INCENP inner centromere protein antigens 135/155kDa
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KATNBL1 katanin p80 subunit B-like 1
KIF20B kinesin family member 20B
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
METTL1 methyltransferase like 1
MID1IP1 MID1 interacting protein 1
MMP13 matrix metallopeptidase 13
MNX1 motor neuron and pancreas homeobox 1
MTRF1 mitochondrial translational release factor 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NMB neuromedin B
NPY1R neuropeptide Y receptor Y1
NR3C2 nuclear receptor subfamily 3, group C, member 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PALMD palmdelphin
PARD6A par-6 family cell polarity regulator alpha
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZD2 PDZ domain containing 2
POLH polymerase (DNA directed), eta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPP1R9A protein phosphatase 1, regulatory subunit 9A
RPP25 ribonuclease P/MRP 25kDa subunit
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD6 SET domain containing 6
SIX1 SIX homeobox 1
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOX12 SRY (sex determining region Y)-box 12
SPAG4 sperm associated antigen 4
SRPX sushi-repeat containing protein, X-linked
STBD1 starch binding domain 1
STK16 serine/threonine kinase 16
STK25 serine/threonine kinase 25
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TEAD3 TEA domain family member 3
TGFB3 transforming growth factor, beta 3
THOC6 THO complex 6
TMEM2 transmembrane protein 2
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSKU tsukushi, small leucine rich proteoglycan
TSPYL2 TSPY-like 2
TSSC1 tumor suppressing subtransferable candidate 1
TULP4 tubby like protein 4
ULK1 unc-51 like autophagy activating kinase 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWA9 von Willebrand factor A domain containing 9
WDR76 WD repeat domain 76
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZMYM3 zinc finger, MYM-type 3
ZNF227 zinc finger protein 227
ZNF426 zinc finger protein 426
ZNF551 zinc finger protein 551
ZNF552 zinc finger protein 552
ZNF696 zinc finger protein 696
ZNF721 zinc finger protein 721
ZNF84 zinc finger protein 84