narcolepsy Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work. (Human Disease Ontology, DOID_8986)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:8986
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Genes

173 genes associated with the disease narcolepsy in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
MRPL24 mitochondrial ribosomal protein L24 2.44927
C6ORF10 chromosome 6 open reading frame 10 2.41441
CENPC centromere protein C 2.40523
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 2.40229
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.36218
JAKMIP2 janus kinase and microtubule interacting protein 2 2.35196
NOTCH4 notch 4 2.34848
FAM171A1 family with sequence similarity 171, member A1 2.34562
CCDC68 coiled-coil domain containing 68 2.34048
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.33959
OXR1 oxidation resistance 1 2.33542
NPFFR2 neuropeptide FF receptor 2 2.33391
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 2.33301
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.32502
POLI polymerase (DNA directed) iota 2.32472
GPC5 glypican 5 2.32441
JPH1 junctophilin 1 2.31937
CTNND2 catenin (cadherin-associated protein), delta 2 2.31927
CSMD3 CUB and Sushi multiple domains 3 2.31154
PHF20 PHD finger protein 20 2.30392
TRIM9 tripartite motif containing 9 2.30365
CATSPER4 cation channel, sperm associated 4 2.30167
ACSS1 acyl-CoA synthetase short-chain family member 1 2.29561
ELMO1 engulfment and cell motility 1 2.28708
NOX4 NADPH oxidase 4 2.28006
MCC mutated in colorectal cancers 2.27988
LOC100507377 uncharacterized LOC100507377 2.27662
ZYG11B zyg-11 family member B, cell cycle regulator 2.26667
TMEM108 transmembrane protein 108 2.26462
FOLR1 folate receptor 1 (adult) 2.26377
DNAH8 dynein, axonemal, heavy chain 8 2.26339
WDR48 WD repeat domain 48 2.26007
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.25914
VAT1L vesicle amine transport 1-like 2.24842
NKAIN3 Na+/K+ transporting ATPase interacting 3 2.24367
SDK1 sidekick cell adhesion molecule 1 2.23946
PRCP prolylcarboxypeptidase (angiotensinase C) 2.23128
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.23038
SUN5 Sad1 and UNC84 domain containing 5 2.22546
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 2.22518
C8ORF34 chromosome 8 open reading frame 34 2.21002
RIT2 Ras-like without CAAX 2 2.20907
LYRM4 LYR motif containing 4 2.20808
TIAM1 T-cell lymphoma invasion and metastasis 1 2.20793
GRM8 glutamate receptor, metabotropic 8 2.20573
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.20245
KIAA0922 KIAA0922 2.20014
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 2.19984
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.19933
MAP3K7 mitogen-activated protein kinase kinase kinase 7 2.19836
PALLD palladin, cytoskeletal associated protein 2.19616
FHOD3 formin homology 2 domain containing 3 2.19456
FSTL5 follistatin-like 5 2.1898
TF transferrin 2.18848
TCERG1 transcription elongation regulator 1 2.18547
ATG5 autophagy related 5 2.18547
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.18517
AGTR1 angiotensin II receptor, type 1 2.18458
ANO3 anoctamin 3 2.18214
PDE4B phosphodiesterase 4B, cAMP-specific 2.18094
RYR2 ryanodine receptor 2 (cardiac) 2.18094
GRM5 glutamate receptor, metabotropic 5 2.17981
NRXN1 neurexin 1 2.17331
BCR breakpoint cluster region 2.17221
CA10 carbonic anhydrase X 2.1681
NKAIN2 Na+/K+ transporting ATPase interacting 2 2.16664
FHIT fragile histidine triad 2.16232
GRID1 glutamate receptor, ionotropic, delta 1 2.16216
FOXP2 forkhead box P2 2.16212
ASTN1 astrotactin 1 2.16133
RBMS3 RNA binding motif, single stranded interacting protein 3 2.15775
ATF6 activating transcription factor 6 2.15759
UNC5D unc-5 homolog D (C. elegans) 2.15733
VAV1 vav 1 guanine nucleotide exchange factor 2.15626
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.15345
KLF12 Kruppel-like factor 12 2.14971
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.14896
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.14774
RNGTT RNA guanylyltransferase and 5'-phosphatase 2.14502
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.14222
RAD50 RAD50 homolog (S. cerevisiae) 2.14128
VAV2 vav 2 guanine nucleotide exchange factor 2.13508
PPARA peroxisome proliferator-activated receptor alpha 2.13427
SFRP1 secreted frizzled-related protein 1 2.13291
SERAC1 serine active site containing 1 2.13253
NT5DC1 5'-nucleotidase domain containing 1 2.13122
LOC339166 uncharacterized LOC339166 2.12445
LINC00536 long intergenic non-protein coding RNA 536 2.12307
BTNL2 butyrophilin-like 2 2.12174
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 2.12129
DPYD dihydropyrimidine dehydrogenase 2.12083
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2.11941
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.11386
GLIS3 GLIS family zinc finger 3 2.11238
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 2.10878
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.10111
NOL4 nucleolar protein 4 2.10051
ANTXR2 anthrax toxin receptor 2 2.09933
MRAS muscle RAS oncogene homolog 2.09515
HINT3 histidine triad nucleotide binding protein 3 2.09255
DCDC2C doublecortin domain containing 2C 2.09168
DHODH dihydroorotate dehydrogenase (quinone) 2.09156
DCHS1 dachsous cadherin-related 1 2.08953
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.08712
DAP3 death associated protein 3 2.08383
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.08267
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.08238
FRMPD2 FERM and PDZ domain containing 2 2.08199
CDK8 cyclin-dependent kinase 8 2.0819
BLMH bleomycin hydrolase 2.07967
CEP112 centrosomal protein 112kDa 2.07797
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.0729
ADAMTSL3 ADAMTS-like 3 2.07102
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.86651
HLA-DRA major histocompatibility complex, class II, DR alpha 1.81643
HDAC9 histone deacetylase 9 1.77929
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.77917
LOC401324 uncharacterized LOC401324 1.76461
EPHB1 EPH receptor B1 1.7322
SHC4 SHC (Src homology 2 domain containing) family, member 4 1.71817
EDNRA endothelin receptor type A 1.70634
SHKBP1 SH3KBP1 binding protein 1 1.67021
ZNF365 zinc finger protein 365 1.63837
PDE7B phosphodiesterase 7B 1.62103
LOC100294145 uncharacterized LOC100294145 1.6187
BARX2 BARX homeobox 2 1.60192
SWAP70 SWAP switching B-cell complex 70kDa subunit 1.60093
ITCH itchy E3 ubiquitin protein ligase 1.59687
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 1.58826
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 1.56451
HOXD-AS2 HOXD cluster antisense RNA 2 1.56312
ASIC2 acid sensing (proton gated) ion channel 2 1.56195
FAM179A family with sequence similarity 179, member A 1.55048
PPAN peter pan homolog (Drosophila) 1.53704
KALRN kalirin, RhoGEF kinase 1.52161
TENM2 teneurin transmembrane protein 2 1.51612
HLA-F-AS1 HLA-F antisense RNA 1 1.51142
FGF10 fibroblast growth factor 10 1.49335
FRY furry homolog (Drosophila) 1.47775
AK5 adenylate kinase 5 1.47748
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.4737
NXPH1 neurexophilin 1 1.4647
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.4625
DENND3 DENN/MADD domain containing 3 1.45494
DPP10 dipeptidyl-peptidase 10 (non-functional) 1.45141
NUP37 nucleoporin 37kDa 1.44903
TMEM132B transmembrane protein 132B 1.41552
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 1.40141
STIM1 stromal interaction molecule 1 1.39523
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.39396
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.38436
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 1.38087
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 1.36817
FXN frataxin 1.36465
AKAP6 A kinase (PRKA) anchor protein 6 1.35253
NFRKB nuclear factor related to kappaB binding protein 1.35197
AGBL1 ATP/GTP binding protein-like 1 1.34689
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.34642
SNX29 sorting nexin 29 1.34552
CHKB-CPT1B CHKB-CPT1B readthrough (NMD candidate) 1.33878
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 1.3387
FREM2 FRAS1 related extracellular matrix protein 2 1.33699
LRRC4C leucine rich repeat containing 4C 1.33685
MAPT-AS1 MAPT antisense RNA 1 1.3316
COLGALT1 collagen beta(1-O)galactosyltransferase 1 1.33142
LRRN1 leucine rich repeat neuronal 1 1.31872
UBXN2B UBX domain protein 2B 1.31635
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 1.14463
CFAP69 cilia and flagella associated protein 69 1.13248
LAMA1 laminin, alpha 1 1.09523
HAL histidine ammonia-lyase 1.05742
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.04489
SNX6 sorting nexin 6 1.02921