necroptotic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. (Gene Ontology, GO_0070266)
External Link http://amigo.geneontology.org/amigo/term/GO:0070266
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Genes

9 genes participating in the necroptotic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
CYLD cylindromatosis (turban tumor syndrome)
FASLG Fas ligand (TNF superfamily, member 6)
IPMK inositol polyphosphate multikinase
ITPK1 inositol-tetrakisphosphate 1-kinase
MLKL mixed lineage kinase domain-like
PGAM5 phosphoglycerate mutase family member 5
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
TRPM7 transient receptor potential cation channel, subfamily M, member 7