necrotic cell death Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. (Gene Ontology, GO_0070265)
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19 genes participating in the necrotic cell death biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CYLD cylindromatosis (turban tumor syndrome)
DNM1L dynamin 1-like
FASLG Fas ligand (TNF superfamily, member 6)
IRF3 interferon regulatory factor 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLKL mixed lineage kinase domain-like
PGAM5 phosphoglycerate mutase family member 5
PPIF peptidylprolyl isomerase F
PYGL phosphorylase, glycogen, liver
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRPM7 transient receptor potential cation channel, subfamily M, member 7