negative regulation of MAPK cascade Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. (Gene Ontology, GO_0043409)
External Link http://amigo.geneontology.org/amigo/term/GO:0043409
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Genes

128 genes participating in the negative regulation of MAPK cascade biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADIPOQ adiponectin, C1Q and collagen domain containing
AGXT alanine-glyoxylate aminotransferase
AIDA axin interactor, dorsalization associated
AMBP alpha-1-microglobulin/bikunin precursor
APOE apolipoprotein E
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CD300A CD300a molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CNKSR3 CNKSR family member 3
CYLD cylindromatosis (turban tumor syndrome)
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB114 defensin, beta 114
DLG1 discs, large homolog 1 (Drosophila)
DSG3 desmoglein 3
DUSP10 dual specificity phosphatase 10
DUSP12 dual specificity phosphatase 12
DUSP13B dual specificity phosphatase 13B
DUSP16 dual specificity phosphatase 16
DUSP19 dual specificity phosphatase 19
DUSP2 dual specificity phosphatase 2
DUSP28 dual specificity phosphatase 28
DUSP29 dual specificity phosphatase 29
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
EMILIN1 elastin microfibril interfacer 1
EPHA4 EPH receptor A4
EPHB2 EPH receptor B2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN1 fibulin 1
FKTN fukutin
FLCN folliculin
FOXM1 forkhead box M1
FOXO1 forkhead box O1
GBA1 glucosylceramidase beta 1
GBP1 guanylate binding protein 1, interferon-inducible
GPER1 G protein-coupled estrogen receptor 1
GPS2 G protein pathway suppressor 2
GSTP1 glutathione S-transferase pi 1
HDAC3 histone deacetylase 3
HYAL2 hyaluronoglucosaminidase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IL1B interleukin 1, beta
INPP5K inositol polyphosphate-5-phosphatase K
IRAK3 interleukin-1 receptor-associated kinase 3
ITCH itchy E3 ubiquitin protein ligase
ITGB1BP1 integrin beta 1 binding protein 1
KLHL31 kelch-like family member 31
LAX1 lymphocyte transmembrane adaptor 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MARVELD3 MARVEL domain containing 3
MECOM MDS1 and EVI1 complex locus
MEN1 multiple endocrine neoplasia I
MISO1 mitochondrial inner membrane subdomain organizer 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NF1 neurofibromin 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAQR3 progestin and adipoQ receptor family member III
PDZD2 PDZ domain containing 2
PEBP1 phosphatidylethanolamine binding protein 1
PER1 period circadian clock 1
PHB1 prohibitin 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PP2D1 protein phosphatase 2C-like domain containing 1
PPARG peroxisome proliferator-activated receptor gamma
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRDM15 PR domain containing 15
PRKCD protein kinase C, delta
PRKN parkin RBR E3 ubiquitin protein ligase
PRMT1 protein arginine methyltransferase 1
PSCA prostate stem cell antigen
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRR protein tyrosine phosphatase, receptor type, R
QARS1 glutaminyl-tRNA synthetase 1
RANBP9 RAN binding protein 9
RGS14 regulator of G-protein signaling 14
RGS2 regulator of G-protein signaling 2
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SBNO1 strawberry notch homolog 1 (Drosophila)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SH2B3 SH2B adaptor protein 3
SH3GL2 SH3-domain GRB2-like 2
SH3RF2 SH3 domain containing ring finger 2
SIRPA signal-regulatory protein alpha
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD4 SMAD family member 4
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STK38 serine/threonine kinase 38
STYXL2 serine/threonine/tyrosine interacting like 2
SYNJ2BP synaptojanin 2 binding protein
TAOK3 TAO kinase 3
TLR4 toll-like receptor 4
TNIP1 TNFAIP3 interacting protein 1
TREM2 triggering receptor expressed on myeloid cells 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNK2 WNK lysine deficient protein kinase 2
XBP1 X-box binding protein 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF675 zinc finger protein 675