negative regulation of T cell activation Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. (Gene Ontology, GO_0050868)
External Link http://amigo.geneontology.org/amigo/term/GO:0050868
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Genes

52 genes participating in the negative regulation of T cell activation biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
BTLA B and T lymphocyte associated
CD274 CD274 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTSG cathepsin G
DLG5 discs, large homolog 5 (Drosophila)
DUSP3 dual specificity phosphatase 3
FGL1 fibrinogen-like 1
FOXP3 forkhead box P3
GLMN glomulin, FKBP associated protein
GPNMB glycoprotein (transmembrane) nmb
HAVCR2 hepatitis A virus cellular receptor 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IFNL1 interferon, lambda 1
IL10 interleukin 10
IL4I1 interleukin 4 induced 1
ILDR2 immunoglobulin-like domain containing receptor 2
JAK3 Janus kinase 3
LAPTM5 lysosomal protein transmembrane 5
LAX1 lymphocyte transmembrane adaptor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G2D phospholipase A2, group IID
PLA2G2F phospholipase A2, group IIF
PLA2G5 phospholipase A2, group V
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RIPOR2 RHO family interacting cell polarization regulator 2
SDC4 syndecan 4
SFTPD surfactant protein D
TIGIT T cell immunoreceptor with Ig and ITIM domains
TINAGL1 tubulointerstitial nephritis antigen-like 1
TIPE2 TNF alpha induced protein 8 like 2
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
UFL1 UFM1-specific ligase 1
VSIG4 V-set and immunoglobulin domain containing 4
VSIR V-set immunoregulatory receptor
VTCN1 V-set domain containing T cell activation inhibitor 1