negative regulation of TOR signaling Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. (Gene Ontology, GO_0032007)
External Link http://amigo.geneontology.org/amigo/term/GO:0032007
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Genes

71 genes participating in the negative regulation of TOR signaling biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
AKT1S1 AKT1 substrate 1 (proline-rich)
ATM ATM serine/threonine kinase
ATXN3 ataxin 3
ATXN3L ataxin 3-like
BMAL1 basic helix-loop-helix ARNT like 1
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2
DDIT4 DNA-damage-inducible transcript 4
DEPDC5 DEP domain containing 5
DEPTOR DEP domain containing MTOR-interacting protein
ENDOG endonuclease G
FLCN folliculin
FNIP1 folliculin interacting protein 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
ITFG2 integrin alpha FG-GAP repeat containing 2
KICS2 KICSTOR subunit 2
KPTN kaptin (actin binding protein)
MAPK3 mitogen-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MINAR1 membrane integral NOTCH2 associated receptor 1
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NLK nemo-like kinase
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
OTUD7B OTU deubiquitinase 7B
PDCD6 programmed cell death 6
PELI1 pellino E3 ubiquitin protein ligase 1
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
RNF152 ring finger protein 152
RNF167 ring finger protein 167
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMTOR S-adenosylmethionine sensor upstream of mTORC1
SAR1A secretion associated, Ras related GTPase 1A
SAR1B secretion associated, Ras related GTPase 1B
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SESN1 sestrin 1
SESN2 sestrin 2
SESN3 sestrin 3
SH3BP4 SH3-domain binding protein 4
SIRT1 sirtuin 1
SPAAR small regulatory polypeptide of amino acid response
STK11 serine/threonine kinase 11
SZT2 seizure threshold 2 homolog (mouse)
TBC1D7 TBC1 domain family, member 7
TBK1 TANK-binding kinase 1
TIPE1 TNF alpha induced protein 8 like 1
TMEM127 transmembrane protein 127
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2N ubiquitin-conjugating enzyme E2N
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBE3A ubiquitin protein ligase E3A
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR24 WD repeat domain 24
WDR59 WD repeat domain 59
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta