negative regulation of cell differentiation Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. (Gene Ontology, GO_0045596)
External Link http://amigo.geneontology.org/amigo/term/GO:0045596
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Genes

221 genes participating in the negative regulation of cell differentiation biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTL6A actin-like 6A
ACTL6B actin-like 6B
ACVR1B activin A receptor, type IB
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADGRV1 adhesion G protein-coupled receptor V1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKRD26 ankyrin repeat domain 26
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ASCL1 achaete-scute family bHLH transcription factor 1
ASXL1 additional sex combs like transcriptional regulator 1
BAMBI BMP and activin membrane-bound inhibitor
BBS12 Bardet-Biedl syndrome 12
BCL7A B-cell CLL/lymphoma 7A
BCL7B B-cell CLL/lymphoma 7B
BCL7C B-cell CLL/lymphoma 7C
BICRA BRD4 interacting chromatin remodeling complex associated protein
BICRAL BICRA like chromatin remodeling complex associated protein
BMAL1 basic helix-loop-helix ARNT like 1
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMP7 bone morphogenetic protein 7
BMP8B bone morphogenetic protein 8b
BRD9 bromodomain containing 9
CALR calreticulin
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CDC73 cell division cycle 73
CDK6 cyclin-dependent kinase 6
CETP cholesteryl ester transfer protein, plasma
CHADL chondroadherin-like
CHRD chordin
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CNTN4 contactin 4
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTR9 CTR9, Paf1/RNA polymerase II complex component
DAB2IP DAB2 interacting protein
DISP3 dispatched RND transporter family member 3
DLL1 delta-like 1 (Drosophila)
DSG2 desmoglein 2
DTX1 deltex 1, E3 ubiquitin ligase
E2F1 E2F transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EID2B EP300 interacting inhibitor of differentiation 2B
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA4 EPH receptor A4
ERFE erythroferrone
ESRRB estrogen-related receptor beta
FBXO11 F-box protein 11
FERMT2 fermitin family member 2
FGF23 fibroblast growth factor 23
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXO1 forkhead box O1
GATA3 GATA binding protein 3
GDF5 growth differentiation factor 5
GPER1 G protein-coupled estrogen receptor 1
GPS2 G protein pathway suppressor 2
GREM1 gremlin 1, DAN family BMP antagonist
GSK3B glycogen synthase kinase 3 beta
HDAC7 histone deacetylase 7
HES5 hes family bHLH transcription factor 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOPX HOP homeobox
HOXA9 homeobox A9
HOXB8 homeobox B8
HPN hepsin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IL17RD interleukin 17 receptor D
IL6 interleukin 6
IPO7 importin 7
IQCB1 IQ motif containing B1
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1 jagged 1
KAT8 K(lysine) acetyltransferase 8
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LIMD1 LIM domains containing 1
LOC102724023 ES1 protein homolog, mitochondrial
LRP3 low density lipoprotein receptor-related protein 3
LRP5 low density lipoprotein receptor-related protein 5
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MARK1 MAP/microtubule affinity-regulating kinase 1
MBD4 methyl-CpG binding domain protein 4
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MEN1 multiple endocrine neoplasia I
METTL14 methyltransferase like 14
MIXL1 Mix paired-like homeobox
MSTN myostatin
MYB v-myb avian myeloblastosis viral oncogene homolog
MYOCD myocardin
NBR1 neighbor of BRCA1 gene 1
NELFB negative elongation factor complex member B
NEPRO nucleolus and neural progenitor protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-1 NK2 homeobox 1
NKX3-2 NK3 homeobox 2
NOCT nocturnin
NOG noggin
NOTCH1 notch 1
NOTCH4 notch 4
NPHP3 nephronophthisis 3 (adolescent)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR5A2 nuclear receptor subfamily 5, group A, member 2
OSR1 odd-skipped related transciption factor 1
OVOL2 ovo-like zinc finger 2
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PKP2 plakophilin 2
POTEF POTE ankyrin domain family, member F
POU4F2 POU class 4 homeobox 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRAME preferentially expressed antigen in melanoma
PTBP1 polypyrimidine tract binding protein 1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGR3 prostaglandin reductase 3
PTHLH parathyroid hormone-like hormone
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RANBP3L RAN binding protein 3-like
RB1 retinoblastoma 1
REST RE1-silencing transcription factor
RIOX1 ribosomal oxygenase 1
RORA RAR-related orphan receptor A
RORB RAR-related orphan receptor B
RTN4 reticulon 4
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCAF1 SR-related CTD-associated factor 1
SDHAF2 succinate dehydrogenase complex assembly factor 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SHH sonic hedgehog
SINHCAF SIN3-HDAC complex associated factor
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIX3 SIX homeobox 3
SKI SKI proto-oncogene
SKIC8 SKI8 subunit of superkiller complex
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SNAI2 snail family zinc finger 2
SOSTDC1 sclerostin domain containing 1
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
SOX4 SRY (sex determining region Y)-box 4
SOX8 SRY (sex determining region Y)-box 8
SOX9 SRY (sex determining region Y)-box 9
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SS18 synovial sarcoma translocation, chromosome 18
SUFU suppressor of fused homolog (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TBX1 T-box 1
TBX3 T-box 3
TBX5 T-box 5
TCF23 transcription factor 23
TENT5C terminal nucleotidyltransferase 5C
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TMEM182 transmembrane protein 182
TMEM53 transmembrane protein 53
TMEM64 transmembrane protein 64
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNN tenascin N
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TRIO trio Rho guanine nucleotide exchange factor
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSKU tsukushi, small leucine rich proteoglycan
TUNAR TCL1 upstream neural differentiation-associated RNA
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
USF3 upstream transcription factor family member 3
USH2A Usher syndrome 2A (autosomal recessive, mild)
VASN vasorin
WNT1 wingless-type MMTV integration site family, member 1
WNT10B wingless-type MMTV integration site family, member 10B
WNT5A wingless-type MMTV integration site family, member 5A
WNT9A wingless-type MMTV integration site family, member 9A
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBED6 zinc finger, BED-type containing 6
ZBTB16 zinc finger and BTB domain containing 16
ZFHX3 zinc finger homeobox 3
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF750 zinc finger protein 750