negative regulation of defense response Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. (Gene Ontology, GO_0031348)
External Link http://amigo.geneontology.org/amigo/term/GO:0031348
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Genes

122 genes participating in the negative regulation of defense response biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACOD1 aconitate decarboxylase 1
ADIPOQ adiponectin, C1Q and collagen domain containing
AHR aryl hydrocarbon receptor
ALOX5 arachidonate 5-lipoxygenase
AOAH acyloxyacyl hydrolase (neutrophil)
APOA1 apolipoprotein A-I
APOE apolipoprotein E
ATG12 autophagy related 12
ATG5 autophagy related 5
AURKB aurora kinase B
BANF1 barrier to autointegration factor 1
C1QBP complement component 1, q subcomponent binding protein
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACTIN cactin, spliceosome C complex subunit
CCN3 cellular communication network factor 3
CDH5 cadherin 5, type 2 (vascular endothelium)
CEP63 centrosomal protein 63kDa
CLEC12A C-type lectin domain family 12, member A
CXCL17 chemokine (C-X-C motif) ligand 17
CYLD cylindromatosis (turban tumor syndrome)
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DTX4 deltex 4, E3 ubiquitin ligase
ELANE elastase, neutrophil expressed
ELF4 E74-like factor 4 (ets domain transcription factor)
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
EXTL3 exostosin-like glycosyltransferase 3
FAM76B family with sequence similarity 76, member B
FEM1C fem-1 homolog c (C. elegans)
FFAR4 free fatty acid receptor 4
FNDC4 fibronectin type III domain containing 4
FPR2 formyl peptide receptor 2
FXR1 fragile X mental retardation, autosomal homolog 1
GATA3 GATA binding protein 3
GBA1 glucosylceramidase beta 1
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GPER1 G protein-coupled estrogen receptor 1
GPR31 G protein-coupled receptor 31
GPS2 G protein pathway suppressor 2
IFI16 interferon, gamma-inducible protein 16
IFT54 intraflagellar transport 54
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL13 interleukin 13
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL4 interleukin 4
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains
IRAK3 interleukin-1 receptor-associated kinase 3
IRGM immunity-related GTPase family, M
ISL1 ISL LIM homeobox 1
ITCH itchy E3 ubiquitin protein ligase
KLF4 Kruppel-like factor 4 (gut)
LONP1 lon peptidase 1, mitochondrial
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
LYAR Ly1 antibody reactive
MACIR macrophage immunometabolism regulator
MAPK7 mitogen-activated protein kinase 7
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEFV Mediterranean fever
METRNL meteorin, glial cell differentiation regulator-like
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MIA3 melanoma inhibitory activity family, member 3
MMP26 matrix metallopeptidase 26
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVK mevalonate kinase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRC3 NLR family, CARD domain containing 3
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NLRP4 NLR family, pyrin domain containing 4
NMI N-myc (and STAT) interactor
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR5A2 nuclear receptor subfamily 5, group A, member 2
OTULIN OTU deubiquitinase with linear linkage specificity
PARP1 poly (ADP-ribose) polymerase 1
PCBP2 poly(rC) binding protein 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKCD protein kinase C, delta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYDC2 pyrin domain containing 2
RB1 retinoblastoma 1
REXO2 RNA exonuclease 2
RNF26 ring finger protein 26
RORA RAR-related orphan receptor A
SAA2 serum amyloid A2
SELENOS selenoprotein S
SHARPIN SHANK-associated RH domain interactor
SIRPA signal-regulatory protein alpha
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TEK TEK tyrosine kinase, endothelial
TIPE2 TNF alpha induced protein 8 like 2
TMSB4X thymosin beta 4, X-linked
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAFD1 TRAF-type zinc finger domain containing 1
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TRIM45 tripartite motif containing 45
TRIM65 tripartite motif containing 65
TYRO3 TYRO3 protein tyrosine kinase
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
USP38 ubiquitin specific peptidase 38
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZDHHC18 zinc finger, DHHC-type containing 18