negative regulation of intracellular signal transduction Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. (Gene Ontology, GO_1902532)
External Link http://amigo.geneontology.org/amigo/term/GO_1902532
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Genes

232 genes participating in the negative regulation of intracellular signal transduction biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRG3 adhesion G protein-coupled receptor G3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AIM2 absent in melanoma 2
AJUBA ajuba LIM protein
AKT1S1 AKT1 substrate 1 (proline-rich)
APLNR apelin receptor
ARHGAP12 Rho GTPase activating protein 12
ARHGAP25 Rho GTPase activating protein 25
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB2 arrestin, beta 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L2 BCL2-like 2
BMP7 bone morphogenetic protein 7
C16ORF72 chromosome 16 open reading frame 72
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACTIN cactin, spliceosome C complex subunit
CARD19 caspase recruitment domain family member 19
CARD8 caspase recruitment domain family, member 8
CASC2 cancer susceptibility candidate 2 (non-protein coding)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CCDC22 coiled-coil domain containing 22
CCN3 cellular communication network factor 3
CD22 CD22 molecule
CD2AP CD2-associated protein
CDC34 cell division cycle 34
CGNL1 cingulin-like 1
CIB1 calcium and integrin binding 1 (calmyrin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CIT citron rho-interacting serine/threonine kinase
CPNE1 copine I
CYLD cylindromatosis (turban tumor syndrome)
CYRIB CYFIP related Rac1 interactor B
DAB2IP DAB2 interacting protein
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DEPDC5 DEP domain containing 5
DEPTOR DEP domain containing MTOR-interacting protein
DGKD diacylglycerol kinase, delta 130kDa
DGKG diacylglycerol kinase, gamma 90kDa
DLG5 discs, large homolog 5 (Drosophila)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1
DUSP1 dual specificity phosphatase 1
DUSP13 dual specificity phosphatase 13
DUSP16 dual specificity phosphatase 16
DUSP2 dual specificity phosphatase 2
DUSP26 dual specificity phosphatase 26 (putative)
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
ENDOG endonuclease G
EPHA2 EPH receptor A2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
FAM89B family with sequence similarity 89, member B
FLCN folliculin
FNIP1 folliculin interacting protein 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPER1 G protein-coupled estrogen receptor 1
GSK3A glycogen synthase kinase 3 alpha
GSTP1 glutathione S-transferase pi 1
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-G major histocompatibility complex, class I, G
HYAL2 hyaluronoglucosaminidase 2
IFI35 interferon-induced protein 35
IGF1R insulin-like growth factor 1 receptor
INPP5K inositol polyphosphate-5-phosphatase K
IRGM immunity-related GTPase family, M
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA1024 KIAA1024
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LIMD1 LIM domains containing 1
LRP1 low density lipoprotein receptor-related protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK3 MAP/microtubule affinity-regulating kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MKRN2 makorin ring finger protein 2
MMP9 matrix metallopeptidase 9
MSTN myostatin
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYADM myeloid-associated differentiation marker
MYO1C myosin IC
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NF1 neurofibromin 1
NLRC3 NLR family, CARD domain containing 3
NLRP12 NLR family, pyrin domain containing 12
NLRP2 NLR family, pyrin domain containing 2
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOP53 NOP53 ribosome biogenesis factor
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUAK1 NUAK family, SNF1-like kinase, 1
NUAK2 NUAK family, SNF1-like kinase, 2
OTUD3 OTU deubiquitinase 3
OTUD7B OTU deubiquitinase 7B
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PBLD phenazine biosynthesis-like protein domain containing
PDCD6 programmed cell death 6
PDE10A phosphodiesterase 10A
PDE11A phosphodiesterase 11A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4D phosphodiesterase 4D, cAMP-specific
PDZD3 PDZ domain containing 3
PEBP1 phosphatidylethanolamine binding protein 1
PER1 period circadian clock 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLAUR plasminogen activator, urokinase receptor
PLEK pleckstrin
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPIF peptidylprolyl isomerase F
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM15 PR domain containing 15
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTPRJ protein tyrosine phosphatase, receptor type, J
PYCARD PYD and CARD domain containing
PYDC2 pyrin domain containing 2
RACK1 receptor for activated C kinase 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHOH ras homolog family member H
RIOK3 RIO kinase 3
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTKN2 rhotekin 2
SFRP5 secreted frizzled-related protein 5
SH2B3 SH2B adaptor protein 3
SH3BP1 SH3-domain binding protein 1
SH3BP4 SH3-domain binding protein 4
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIRT1 sirtuin 1
SLA2 Src-like-adaptor 2
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT2 slit homolog 2 (Drosophila)
SORD sorbitol dehydrogenase
SPI1 Spi-1 proto-oncogene
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY3 sprouty homolog 3 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STYXL2 serine/threonine/tyrosine interacting like 2
TANK TRAF family member-associated NFKB activator
TBC1D7 TBC1 domain family, member 7
THBS1 thrombospondin 1
TIPE1 TNF alpha induced protein 8 like 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM127 transmembrane protein 127
TMSB4X thymosin beta 4, X-linked
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TNIP3 TNFAIP3 interacting protein 3
TREM2 triggering receptor expressed on myeloid cells 2
TRIM15 tripartite motif containing 15
TRIM39 tripartite motif containing 39
TRIM40 tripartite motif containing 40
TRIM59 tripartite motif containing 59
TRIM60 tripartite motif containing 60
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSPAN6 tetraspanin 6
TSSK1B testis-specific serine kinase 1B
TSSK2 testis-specific serine kinase 2
TSSK3 testis-specific serine kinase 3
TSSK6 testis-specific serine kinase 6
TWIST1 twist family bHLH transcription factor 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBE2B ubiquitin-conjugating enzyme E2B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
URI1 URI1, prefoldin-like chaperone
USP10 ubiquitin specific peptidase 10
USP20 ubiquitin specific peptidase 20
VEPH1 ventricular zone expressed PH domain-containing 1
VGLL4 vestigial-like family member 4
WTIP Wilms tumor 1 interacting protein
WWC1 WW and C2 domain containing 1
WWC2 WW and C2 domain containing 2
WWC3 WWC family member 3
ZC3H12A zinc finger CCCH-type containing 12A
ZMYND11 zinc finger, MYND-type containing 11