negative regulation of intracellular signal transduction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. (Gene Ontology, GO_1902532)
External Link http://amigo.geneontology.org/amigo/term/GO:1902532
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Genes

298 genes participating in the negative regulation of intracellular signal transduction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
AARS1 alanyl-tRNA synthetase 1
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRG3 adhesion G protein-coupled receptor G3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AIM2 absent in melanoma 2
AJUBA ajuba LIM protein
AKT1S1 AKT1 substrate 1 (proline-rich)
APLNR apelin receptor
ARHGAP12 Rho GTPase activating protein 12
ARHGAP17 Rho GTPase activating protein 17
ARHGAP22 Rho GTPase activating protein 22
ARHGAP25 Rho GTPase activating protein 25
ARHGAP29 Rho GTPase activating protein 29
ARHGAP45 Rho GTPase activating protein 45
ARRB2 arrestin, beta 2
ASXL1 additional sex combs like transcriptional regulator 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BMAL1 basic helix-loop-helix ARNT like 1
BMP7 bone morphogenetic protein 7
C1D C1D nuclear receptor corepressor
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACTIN cactin, spliceosome C complex subunit
CALR calreticulin
CARD19 caspase recruitment domain family member 19
CARD8 caspase recruitment domain family, member 8
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CCDC22 coiled-coil domain containing 22
CCN3 cellular communication network factor 3
CD22 CD22 molecule
CD2AP CD2-associated protein
CGNL1 cingulin-like 1
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CIB1 calcium and integrin binding 1 (calmyrin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNOT1 CCR4-NOT transcription complex, subunit 1
CPNE1 copine I
CREBRF CREB3 regulatory factor
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNND1 catenin (cadherin-associated protein), delta 1
CYLD cylindromatosis (turban tumor syndrome)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1
CYRIB CYFIP related Rac1 interactor B
DAB2IP DAB2 interacting protein
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DEPTOR DEP domain containing MTOR-interacting protein
DGKD diacylglycerol kinase, delta 130kDa
DGKG diacylglycerol kinase, gamma 90kDa
DHDDS dehydrodolichyl diphosphate synthase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUSP12 dual specificity phosphatase 12
DUSP13B dual specificity phosphatase 13B
DUSP16 dual specificity phosphatase 16
DUSP2 dual specificity phosphatase 2
DUSP28 dual specificity phosphatase 28
DUSP29 dual specificity phosphatase 29
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP8 dual specificity phosphatase 8
EDN1 endothelin 1
EID2 EP300 interacting inhibitor of differentiation 2
EMILIN1 elastin microfibril interfacer 1
ENDOG endonuclease G
ENG endoglin
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM89B family with sequence similarity 89, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLCN folliculin
FNIP1 folliculin interacting protein 1
GBA1 glucosylceramidase beta 1
GDF15 growth differentiation factor 15
GMIP GEM interacting protein
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HAPSTR1 HUWE1 associated protein modifying stress responses
HDAC7 histone deacetylase 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-G major histocompatibility complex, class I, G
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HYAL2 hyaluronoglucosaminidase 2
IFI35 interferon-induced protein 35
IGF1R insulin-like growth factor 1 receptor
INPP5K inositol polyphosphate-5-phosphatase K
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRGM immunity-related GTPase family, M
ITCH itchy E3 ubiquitin protein ligase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KANK2 KN motif and ankyrin repeat domains 2
KLF4 Kruppel-like factor 4 (gut)
LAX1 lymphocyte transmembrane adaptor 1
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LIMD1 LIM domains containing 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAPK14 mitogen-activated protein kinase 14
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK3 MAP/microtubule affinity-regulating kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MINAR1 membrane integral NOTCH2 associated receptor 1
MKRN2 makorin ring finger protein 2
MLXIPL MLX interacting protein-like
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMP9 matrix metallopeptidase 9
MOB4 MOB family member 4, phocein
MORN3 MORN repeat containing 3
MSTN myostatin
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NF1 neurofibromin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHERF4 NHERF family PDZ scaffold protein 4
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NLRC3 NLR family, CARD domain containing 3
NLRP12 NLR family, pyrin domain containing 12
NLRP2 NLR family, pyrin domain containing 2
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NMI N-myc (and STAT) interactor
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOG noggin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOP53 NOP53 ribosome biogenesis factor
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
OPRM1 opioid receptor, mu 1
OTUD3 OTU deubiquitinase 3
OTUD7B OTU deubiquitinase 7B
OVOL2 ovo-like zinc finger 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAQR3 progestin and adipoQ receptor family member III
PDCD6 programmed cell death 6
PDE10A phosphodiesterase 10A
PDE11A phosphodiesterase 11A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDZD2 PDZ domain containing 2
PEBP1 phosphatidylethanolamine binding protein 1
PER1 period circadian clock 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAUR plasminogen activator, urokinase receptor
PLEK pleckstrin
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLIN5 perilipin 5
PLK3 polo-like kinase 3
PMEPA1 prostate transmembrane protein, androgen induced 1
PP2D1 protein phosphatase 2C-like domain containing 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPIF peptidylprolyl isomerase F
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRAME preferentially expressed antigen in melanoma
PRDM15 PR domain containing 15
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTPRJ protein tyrosine phosphatase, receptor type, J
PYCARD PYD and CARD domain containing
PYDC1 PYD (pyrin domain) containing 1
PYDC2 pyrin domain containing 2
RACK1 receptor for activated C kinase 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHOH ras homolog family member H
RIOK3 RIO kinase 3
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF39 ring finger protein 39
RORA RAR-related orphan receptor A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTKN2 rhotekin 2
RUBCN rubicon autophagy regulator
SBNO1 strawberry notch homolog 1 (Drosophila)
SFRP5 secreted frizzled-related protein 5
SH2B3 SH2B adaptor protein 3
SH3BP1 SH3-domain binding protein 1
SH3BP4 SH3-domain binding protein 4
SH3GL2 SH3-domain GRB2-like 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIKE1 suppressor of IKBKE 1
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SIRT7 sirtuin 7
SKI SKI proto-oncogene
SLA2 Src-like-adaptor 2
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT2 slit homolog 2 (Drosophila)
SLMAP sarcolemma associated protein
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNAI2 snail family zinc finger 2
SPI1 Spi-1 proto-oncogene
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY3 sprouty homolog 3 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STRIP1 striatin interacting protein 1
STRN3 striatin, calmodulin binding protein 3
STRN4 striatin, calmodulin binding protein 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STYXL2 serine/threonine/tyrosine interacting like 2
TANK TRAF family member-associated NFKB activator
TARBP2 TAR (HIV-1) RNA binding protein 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D7 TBC1 domain family, member 7
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
THEM4 thioesterase superfamily member 4
TIPE1 TNF alpha induced protein 8 like 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMC8 transmembrane channel-like 8
TMEM127 transmembrane protein 127
TMSB4X thymosin beta 4, X-linked
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TNIP3 TNFAIP3 interacting protein 3
TREM2 triggering receptor expressed on myeloid cells 2
TRIM15 tripartite motif containing 15
TRIM39 tripartite motif containing 39
TRIM40 tripartite motif containing 40
TRIM59 tripartite motif containing 59
TRIM60 tripartite motif containing 60
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSPAN6 tetraspanin 6
TWIST1 twist family bHLH transcription factor 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
URI1 URI1, prefoldin-like chaperone
USP20 ubiquitin specific peptidase 20
USP32 ubiquitin specific peptidase 32
USP49 ubiquitin specific peptidase 49
VCP valosin containing protein
VEPH1 ventricular zone expressed PH domain-containing 1
VGLL4 vestigial-like family member 4
WNK1 WNK lysine deficient protein kinase 1
WTIP Wilms tumor 1 interacting protein
WWC1 WW and C2 domain containing 1
WWC2 WW and C2 domain containing 2
WWC3 WWC family member 3
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZMYND11 zinc finger, MYND-type containing 11
ZNF675 zinc finger protein 675