negative regulation of macromolecule metabolic process Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. (Gene Ontology, GO_0010605)
External Link http://amigo.geneontology.org/amigo/term/GO_0010605
Similar Terms
Downloads & Tools

Genes

187 genes participating in the negative regulation of macromolecule metabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACVRL1 activin A receptor type II-like 1
ADAM10 ADAM metallopeptidase domain 10
AMH anti-Mullerian hormone
ANXA7 annexin A7
AP1AR adaptor-related protein complex 1 associated regulatory protein
APLN apelin
APLNR apelin receptor
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATOH8 atonal homolog 8 (Drosophila)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
CCDC3 coiled-coil domain containing 3
CCL3 chemokine (C-C motif) ligand 3
CCR1 chemokine (C-C motif) receptor 1
CD28 CD28 molecule
CD34 CD34 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD46 CD46 molecule, complement regulatory protein
CELF1 CUGBP, Elav-like family member 1
CHD4 chromodomain helicase DNA binding protein 4
CHMP1A charged multivesicular body protein 1A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN19 claudin 19
CLDN3 claudin 3
CLDN5 claudin 5
CNOT7 CCR4-NOT transcription complex, subunit 7
CNPY2 canopy FGF signaling regulator 2
CPNE1 copine I
CREB3L1 cAMP responsive element binding protein 3-like 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXCL8 chemokine (C-X-C motif) ligand 8
DAXX death-domain associated protein
DDRGK1 DDRGK domain containing 1
DGKQ diacylglycerol kinase, theta 110kDa
DICER1 dicer 1, ribonuclease type III
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DLL4 delta-like 4 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EDN1 endothelin 1
EDNRB endothelin receptor type B
EMILIN1 elastin microfibril interfacer 1
ENG endoglin
ERP29 endoplasmic reticulum protein 29
ESR1 estrogen receptor 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FLCN folliculin
FLOT2 flotillin 2
FOXP1 forkhead box P1
GATA2 GATA binding protein 2
GATA5 GATA binding protein 5
GPER1 G protein-coupled estrogen receptor 1
GSK3B glycogen synthase kinase 3 beta
HAND2 heart and neural crest derivatives expressed 2
HAVCR2 hepatitis A virus cellular receptor 2
HDAC1 histone deacetylase 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINFP histone H4 transcription factor
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
INS insulin
ITGB8 integrin, beta 8
KDM4A lysine (K)-specific demethylase 4A
KDR kinase insert domain receptor
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LGALS9 lectin, galactoside-binding, soluble, 9
LGMN legumain
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LOC105375355 uroplakin-3b
LRP1 low density lipoprotein receptor-related protein 1
LRP3 low density lipoprotein receptor-related protein 3
MAPT microtubule-associated protein tau
MARK1 MAP/microtubule affinity-regulating kinase 1
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
MMP8 matrix metallopeptidase 8
MSR1 macrophage scavenger receptor 1
MTMR2 myotubularin related protein 2
MYADM myeloid-associated differentiation marker
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDFIP1 Nedd4 family interacting protein 1
NDFIP2 Nedd4 family interacting protein 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-1 NK3 homeobox 1
NOCT nocturnin
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOTCH2 notch 2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NTS neurotensin
OCLN occludin
OLFM1 olfactomedin 1
OPRD1 opioid receptor, delta 1
OPTN optineurin
OVOL2 ovo-like zinc finger 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP10 poly (ADP-ribose) polymerase family, member 10
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP15 poly (ADP-ribose) polymerase family, member 15
PARP9 poly (ADP-ribose) polymerase family, member 9
PCSK9 proprotein convertase subtilisin/kexin type 9
PDCD10 programmed cell death 10
PDGFB platelet-derived growth factor beta polypeptide
PGR progesterone receptor
PICALM phosphatidylinositol binding clathrin assembly protein
PINK1 PTEN induced putative kinase 1
PLA2G3 phospholipase A2, group III
POU4F1 POU class 4 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSEN1 presenilin 1
PTH parathyroid hormone
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTRH2 peptidyl-tRNA hydrolase 2
RACK1 receptor for activated C kinase 1
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBMS3 RNA binding motif, single stranded interacting protein 3
REL v-rel avian reticuloendotheliosis viral oncogene homolog
REST RE1-silencing transcription factor
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SETDB1 SET domain, bifurcated 1
SETDB2 SET domain, bifurcated 2
SFMBT2 Scm-like with four mbt domains 2
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SH3GL2 SH3-domain GRB2-like 2
SIRT1 sirtuin 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
SMO smoothened, frizzled class receptor
SNX12 sorting nexin 12
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
SPI1 Spi-1 proto-oncogene
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC2 stanniocalcin 2
STOX1 storkhead box 1
SUB1 SUB1 homolog (S. cerevisiae)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TARDBP TAR DNA binding protein
TCEAL1 transcription elongation factor A (SII)-like 1
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE5 TLE family member 5, transcriptional modulator
TNF tumor necrosis factor
TRAT1 T cell receptor associated transmembrane adaptor 1
TRIM6 tripartite motif containing 6
TTBK1 tau tubulin kinase 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT4 wingless-type MMTV integration site family, member 4
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YAP1 Yes-associated protein 1
YY1 YY1 transcription factor
ZC3H12A zinc finger CCCH-type containing 12A
ZNF148 zinc finger protein 148
ZNF281 zinc finger protein 281
ZNF410 zinc finger protein 410
ZNF503 zinc finger protein 503