Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. (Gene Ontology, GO_0010605)
11 genes participating in the negative regulation of macromolecule metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.
