negative regulation of signal transduction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. (Gene Ontology, GO_0009968)
External Link http://amigo.geneontology.org/amigo/term/GO:0009968
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Genes

278 genes participating in the negative regulation of signal transduction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACOD1 aconitate decarboxylase 1
ACVR1 activin A receptor, type I
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGTR2 angiotensin II receptor, type 2
AGXT alanine-glyoxylate aminotransferase
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT1 angiopoietin 1
APCDD1 adenomatosis polyposis coli down-regulated 1
APLN apelin
APOD apolipoprotein D
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARRB1 arrestin, beta 1
ARRDC1 arrestin domain containing 1
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BEND6 BEN domain containing 6
BLVRB biliverdin reductase B
BMP2 bone morphogenetic protein 2
BMP5 bone morphogenetic protein 5
BPIFB1 BPI fold containing family B, member 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C12ORF43 chromosome 12 open reading frame 43
C1D C1D nuclear receptor corepressor
C6ORF89 chromosome 6 open reading frame 89
CACTIN cactin, spliceosome C complex subunit
CADM4 cell adhesion molecule 4
CARD16 caspase recruitment domain family, member 16
CARD8 caspase recruitment domain family, member 8
CBY1 chibby homolog 1 (Drosophila)
CCL5 chemokine (C-C motif) ligand 5
CCNC cyclin C
CDK3 cyclin-dependent kinase 3
CER1 cerberus 1, DAN family BMP antagonist
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLEC12B C-type lectin domain family 12, member B
CREB3L1 cAMP responsive element binding protein 3-like 1
CRHBP corticotropin releasing hormone binding protein
CRY1 cryptochrome circadian clock 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CUL7 cullin 7
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXXC4 CXXC finger protein 4
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DACT3 dishevelled-binding antagonist of beta-catenin 3
DCN decorin
DEFB114 defensin, beta 114
DEFB118 defensin, beta 118
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK4 dickkopf WNT signaling pathway inhibitor 4
DLK1 delta-like 1 homolog (Drosophila)
DLK2 delta-like 2 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DLL4 delta-like 4 (Drosophila)
EGFL7 EGF-like-domain, multiple 7
EMILIN1 elastin microfibril interfacer 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENTREP1 endosomal transmembrane epsin interactor 1
EPHB2 EPH receptor B2
EPN2 epsin 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
FGF13 fibroblast growth factor 13
FRZB frizzled-related protein
FSTL3 follistatin-like 3 (secreted glycoprotein)
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GBA1 glucosylceramidase beta 1
GDF15 growth differentiation factor 15
GLI3 GLI family zinc finger 3
GLIS2 GLIS family zinc finger 2
GPC1 glypican 1
GPC3 glypican 3
GPR108 G protein-coupled receptor 108
GPS2 G protein pathway suppressor 2
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRB7 growth factor receptor-bound protein 7
GSK3A glycogen synthase kinase 3 alpha
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HHEX hematopoietically expressed homeobox
HHIP hedgehog interacting protein
HIC1 hypermethylated in cancer 1
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGXB4 HMG box domain containing 4
IFT122 intraflagellar transport 122
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL1B interleukin 1, beta
IL36RN interleukin 36 receptor antagonist
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
IRAK3 interleukin-1 receptor-associated kinase 3
IRS1 insulin receptor substrate 1
KANK1 KN motif and ankyrin repeat domains 1
KCTD21 potassium channel tetramerization domain containing 21
KCTD6 potassium channel tetramerization domain containing 6
KIF26A kinesin family member 26A
KIF7 kinesin family member 7
KLK14 kallikrein-related peptidase 14
LACRT lacritin
LEPROT leptin receptor overlapping transcript
LEPROTL1 leptin receptor overlapping transcript-like 1
LGMN legumain
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC14 leucine rich repeat containing 14
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA1 melanoma antigen family A1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MDFI MyoD family inhibitor
MEGF8 multiple EGF-like-domains 8
METTL3 methyltransferase like 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMRN1 multimerin 1
MMRN2 multimerin 2
MOSMO modulator of smoothened
MPIG6B megakaryocyte and platelet inhibitory receptor G6b
NCK1 NCK adaptor protein 1
NCOA2 nuclear receptor coactivator 2
NDRG4 NDRG family member 4
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKD1 naked cuticle homolog 1 (Drosophila)
NKD2 naked cuticle homolog 2 (Drosophila)
NKX3-1 NK3 homeobox 1
NLK nemo-like kinase
NLRP12 NLR family, pyrin domain containing 12
NLRP2B NLR family pyrin domain containing 2B
NOG noggin
NOTUM notum pectinacetylesterase homolog (Drosophila)
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRARP NOTCH-regulated ankyrin repeat protein
NXN nucleoredoxin
OTUD4 OTU deubiquitinase 4
OVOL2 ovo-like zinc finger 2
PALM3 paralemmin 3
PDCD6 programmed cell death 6
PHACTR4 phosphatase and actin regulator 4
PID1 phosphotyrosine interaction domain containing 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLEK pleckstrin
PPARG peroxisome proliferator-activated receptor gamma
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PTCH1 patched 1
PTCH2 patched 2
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRT protein tyrosine phosphatase, receptor type, T
QARS1 glutaminyl-tRNA synthetase 1
RAB7B RAB7B, member RAS oncogene family
RACK1 receptor for activated C kinase 1
RB1 retinoblastoma 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGS14 regulator of G-protein signaling 14
RGS2 regulator of G-protein signaling 2
RGS7 regulator of G-protein signaling 7
RITA1 RBPJ interacting and tubulin associated 1
RNF115 ring finger protein 115
RNF43 ring finger protein 43
RPGRIP1L RPGRIP1-like
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SH2B3 SH2B adaptor protein 3
SHISA2 shisa family member 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIRPA signal-regulatory protein alpha
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD5 SMAD family member 5
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS5 suppressor of cytokine signaling 5
SOST sclerostin
SOSTDC1 sclerostin domain containing 1
SOX30 SRY (sex determining region Y)-box 30
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
SUFU suppressor of fused homolog (Drosophila)
SULF1 sulfatase 1
SULF2 sulfatase 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCIM transcriptional and immune response regulator
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR6 toll-like receptor 6
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED7-TICAM2 TMED7-TICAM2 readthrough
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS2 tensin 2
TRABD2A TraB domain containing 2A
TRABD2B TraB domain containing 2B
TREM2 triggering receptor expressed on myeloid cells 2
TRIB1 tribbles pseudokinase 1
TRIM32 tripartite motif containing 32
TSC2 tuberous sclerosis 2
TSKU tsukushi, small leucine rich proteoglycan
TSPAN15 tetraspanin 15
TULP3 tubby like protein 3
TYRO3 TYRO3 protein tyrosine kinase
UBASH3B ubiquitin associated and SH3 domain containing B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
ULK3 unc-51 like kinase 3
VCP valosin containing protein
VGLL4 vestigial-like family member 4
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WIF1 WNT inhibitory factor 1
WNT16 wingless-type MMTV integration site family, member 16
WWOX WW domain containing oxidoreductase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB7A zinc finger and BTB domain containing 7A
ZNF653 zinc finger protein 653
ZNF675 zinc finger protein 675