negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. (Gene Ontology, GO_0090101)
External Link http://amigo.geneontology.org/amigo/term/GO:0090101
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Genes

123 genes participating in the negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACVR1 activin A receptor, type I
ADAM17 ADAM metallopeptidase domain 17
ADAMTSL2 ADAMTS-like 2
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
BCL9L B-cell CLL/lymphoma 9-like
BMP2 bone morphogenetic protein 2
BRMS1L breast cancer metastasis-suppressor 1-like
C1D C1D nuclear receptor corepressor
CAV1 caveolin 1, caveolae protein, 22kDa
CCN3 cellular communication network factor 3
CD109 CD109 molecule
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CER1 cerberus 1, DAN family BMP antagonist
CHRD chordin
CHRDL1 chordin-like 1
CHRDL2 chordin-like 2
CIDEA cell death-inducing DFFA-like effector a
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DAND5 DAN domain family member 5, BMP antagonist
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX1 distal-less homeobox 1
EID2 EP300 interacting inhibitor of differentiation 2
EMILIN1 elastin microfibril interfacer 1
ENG endoglin
ERFE erythroferrone
FAM89B family with sequence similarity 89, member B
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1C FK506 binding protein 1C
FST follistatin
FSTL3 follistatin-like 3 (secreted glycoprotein)
GDF15 growth differentiation factor 15
GDF3 growth differentiation factor 3
GPR155 G protein-coupled receptor 155
GREM1 gremlin 1, DAN family BMP antagonist
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIPK2 homeodomain interacting protein kinase 2
HSPA1A heat shock 70kDa protein 1A
HTRA3 HtrA serine peptidase 3
HTRA4 HtrA serine peptidase 4
IGSF1 immunoglobulin superfamily, member 1
IL17RD interleukin 17 receptor D
ING1 inhibitor of growth family, member 1
ING3 inhibitor of growth family, member 3
INTS9 integrator complex subunit 9
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LEMD3 LEM domain containing 3
LINC02762 long intergenic non-protein coding RNA 2762
LRP2 low density lipoprotein receptor-related protein 2
LRRC32 leucine rich repeat containing 32
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MECOM MDS1 and EVI1 complex locus
MTMR4 myotubularin related protein 4
NKX2-1 NK2 homeobox 1
NOG noggin
NOTCH1 notch 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OVOL2 ovo-like zinc finger 2
PBLD phenazine biosynthesis-like protein domain containing
PDPK1 3-phosphoinositide dependent protein kinase 1
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRDM16 PR domain containing 16
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBPMS2 RNA binding protein with multiple splicing 2
SAP130 Sin3A-associated protein, 130kDa
SAP30 Sin3A-associated protein, 30kDa
SAP30L SAP30-like
SIN3A SIN3 transcription regulator family member A
SINHCAF SIN3-HDAC complex associated factor
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SKOR1 SKI family transcriptional corepressor 1
SKOR2 SKI family transcriptional corepressor 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNX25 sorting nexin 25
SNX6 sorting nexin 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOST sclerostin
SOSTDC1 sclerostin domain containing 1
SPART spartin
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRFBP1 serum response factor binding protein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
TET1 tet methylcytosine dioxygenase 1
TGFBR3 transforming growth factor, beta receptor III
TMEM53 transmembrane protein 53
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM33 tripartite motif containing 33
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
USP15 ubiquitin specific peptidase 15
VASN vasorin
VEPH1 ventricular zone expressed PH domain-containing 1
VWC2 von Willebrand factor C domain containing 2
VWC2L von Willebrand factor C domain containing protein 2-like
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
WNT1 wingless-type MMTV integration site family, member 1
XBP1 X-box binding protein 1
ZBTB7A zinc finger and BTB domain containing 7A
ZNF451 zinc finger protein 451