nephropathy Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A disease affecting the kidneys (Experimental Factor Ontology, EFO_0003086)
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Genes

418 genes co-occuring with the biological term nephropathy in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACACB acetyl-CoA carboxylase beta
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTA1 actin, alpha 1, skeletal muscle
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN4 actinin, alpha 4
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADM adrenomedullin
ADRB1 adrenoceptor beta 1
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AIF1 allograft inflammatory factor 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APOL1 apolipoprotein L, 1
AQP2 aquaporin 2 (collecting duct)
AQP5 aquaporin 5
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
B2M beta-2-microglobulin
BDKRB2 bradykinin receptor B2
BMP7 bone morphogenetic protein 7
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C1GALT1C1 C1GALT1-specific chaperone 1
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C5 complement component 5
CALD1 caldesmon 1
CARD9 caspase recruitment domain family, member 9
CASP12 caspase 12 (gene/pseudogene)
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCKAR cholecystokinin A receptor
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD2AP CD2-associated protein
CD4 CD4 molecule
CD40LG CD40 ligand
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELA1 chymotrypsin-like elastase family, member 1
CFH complement factor H
CFHR5 complement factor H-related 5
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CMA1 chymase 1, mast cell
CMIP c-Maf inducing protein
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CNR1 cannabinoid receptor 1 (brain)
CNSN Carnosinemia (carnosinase)
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYLD cylindromatosis (turban tumor syndrome)
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCN decorin
DDN dendrin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFT1P2 defensin, theta 1 pseudogene 2
DNASE1 deoxyribonuclease I
EDN1 endothelin 1
EGF epidermal growth factor
ELMO1 engulfment and cell motility 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
ERBB4 erb-b2 receptor tyrosine kinase 4
ERRFI1 ERBB receptor feedback inhibitor 1
EXT1 exostosin glycosyltransferase 1
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F5 coagulation factor V (proaccelerin, labile factor)
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FCAR Fc fragment of IgA receptor
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCRLB Fc receptor-like B
FGA fibrinogen alpha chain
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FN3K fructosamine 3 kinase
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FRMD3 FERM domain containing 3
GAS6 growth arrest-specific 6
GCM1 glial cells missing homolog 1 (Drosophila)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GHRL ghrelin/obestatin prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GSK3A glycogen synthase kinase 3 alpha
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HAVCR1 hepatitis A virus cellular receptor 1
HBA1 hemoglobin, alpha 1
HES1 hes family bHLH transcription factor 1
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HP haptoglobin
HPSE heparanase
HPX hemopexin
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPG2 heparan sulfate proteoglycan 2
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGHA1 immunoglobulin heavy constant alpha 1
IGHMBP2 immunoglobulin mu binding protein 2
IL10 interleukin 10
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL4 interleukin 4
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
IRS2 insulin receptor substrate 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JAG1 jagged 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JUN jun proto-oncogene
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KHK ketohexokinase (fructokinase)
KIRREL kin of IRRE like (Drosophila)
KITLG KIT ligand
KL klotho
KLF6 Kruppel-like factor 6
KLK1 kallikrein 1
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA4 karyopherin alpha 4 (importin alpha 3)
L1CAM L1 cell adhesion molecule
LAMP3 lysosomal-associated membrane protein 3
LCAT lecithin-cholesterol acyltransferase
LCN2 lipocalin 2
LEP leptin
LIPC lipase, hepatic
LMX1B LIM homeobox transcription factor 1, beta
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LRRC7 leucine rich repeat containing 7
LTBP1 latent transforming growth factor beta binding protein 1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAPK14 mitogen-activated protein kinase 14
MARK2 MAP/microtubule affinity-regulating kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCAM melanoma cell adhesion molecule
MCF2L2 MCF.2 cell line derived transforming sequence-like 2
MDK midkine (neurite growth-promoting factor 2)
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR135A1 microRNA 135a-1
MIR135A2 microRNA 135a-2
MIR146A microRNA 146a
MIR148B microRNA 148b
MIR155 microRNA 155
MIR192 microRNA 192
MIR200C microRNA 200c
MIR21 microRNA 21
MIR223 microRNA 223
MIR377 microRNA 377
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTMR3 myotubularin related protein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYH9 myosin, heavy chain 9, non-muscle
NAMPT nicotinamide phosphoribosyltransferase
NCALD neurocalcin delta
NES nestin
NEUROD1 neuronal differentiation 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NOX1 NADPH oxidase 1
NOX3 NADPH oxidase 3
NOX4 NADPH oxidase 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPY neuropeptide Y
NRP1 neuropilin 1
NRP2 neuropilin 2
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARL presenilin associated, rhomboid-like
PDCD1 programmed cell death 1
PDE5A phosphodiesterase 5A, cGMP-specific
PDGFB platelet-derived growth factor beta polypeptide
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PGC progastricsin (pepsinogen C)
PIGR polymeric immunoglobulin receptor
PKLR pyruvate kinase, liver and RBC
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAU plasminogen activator, urokinase
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PODXL podocalyxin-like
PON1 paraoxonase 1
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRSS1 protease, serine, 1 (trypsin 1)
PRSS2 protease, serine, 2 (trypsin 2)
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTEN phosphatase and tensin homolog
PTER phosphotriesterase related
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
PVT1 Pvt1 oncogene (non-protein coding)
RAP1B RAP1B, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RBP4 retinol binding protein 4, plasma
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RHOA ras homolog family member A
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCAF4 SR-related CTD-associated factor 4
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SDK1 sidekick cell adhesion molecule 1
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHBG sex hormone-binding globulin
SIRT1 sirtuin 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAI1 snail family zinc finger 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOX2 SRY (sex determining region Y)-box 2
SP3 Sp3 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
SUMO4 small ubiquitin-like modifier 4
SYK spleen tyrosine kinase
SYNPO synaptopodin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THBS1 thrombospondin 1
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
THSD7A thrombospondin, type I, domain containing 7A
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKT transketolase
TKTL1 transketolase-like 1
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNR tenascin R
TP53 tumor protein p53
TRA T cell receptor alpha locus
TRDN triadin
TRIB3 tribbles pseudokinase 3
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSC22D1 TSC22 domain family, member 1
TWIST1 twist family bHLH transcription factor 1
UBD ubiquitin D
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UMOD uromodulin
UNC13B unc-13 homolog B (C. elegans)
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWCE von Willebrand factor C and EGF domains
VWF von Willebrand factor
WT1 Wilms tumor 1
WTAP Wilms tumor 1 associated protein
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XYLT1 xylosyltransferase I
XYLT2 xylosyltransferase II