neural tube closure Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. (Gene Ontology, GO_0001843)
External Link http://amigo.geneontology.org/amigo/term/GO:0001843
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Genes

31 genes participating in the neural tube closure biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
BBS4 Bardet-Biedl syndrome 4
BCL10 B-cell CLL/lymphoma 10
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
COBL cordon-bleu WH2 repeat protein
DEAF1 DEAF1 transcription factor
DLC1 DLC1 Rho GTPase activating protein
DVL2 dishevelled segment polarity protein 2
FOLR2 folate receptor 2 (fetal)
FUZ fuzzy planar cell polarity protein
GRHL2 grainyhead-like 2 (Drosophila)
GRHL3 grainyhead-like 3 (Drosophila)
IFT122 intraflagellar transport 122
KDM2B lysine (K)-specific demethylase 2B
LMO4 LIM domain only 4
LRP2 low density lipoprotein receptor-related protein 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PAX2 paired box 2
PHACTR4 phosphatase and actin regulator 4
PLXNB2 plexin B2
PRICKLE1 prickle homolog 1 (Drosophila)
SCRIB scribbled planar cell polarity protein
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SKI SKI proto-oncogene
STIL SCL/TAL1 interrupting locus
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TSC2 tuberous sclerosis 2
VANGL2 VANGL planar cell polarity protein 2
VASP vasodilator-stimulated phosphoprotein