neuroblastomas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.|A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)|A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome (MeSH). (Experimental Factor Ontology, EFO_0000621)
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Genes

54 genes co-occuring with the biological term neuroblastomas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ALX3 ALX homeobox 3
ANG angiogenin, ribonuclease, RNase A family, 5
BIRC5 baculoviral IAP repeat containing 5
CA9 carbonic anhydrase IX
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CD44 CD44 molecule (Indian blood group)
CDON cell adhesion associated, oncogene regulated
CHD5 chromodomain helicase DNA binding protein 5
CHRM1 cholinergic receptor, muscarinic 1
CHRM3 cholinergic receptor, muscarinic 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EPB41 erythrocyte membrane protein band 4.1
EPO erythropoietin
EPOR erythropoietin receptor
GRP gastrin-releasing peptide
IGF1R insulin-like growth factor 1 receptor
ING1 inhibitor of growth family, member 1
INSRR insulin receptor-related receptor
KDR kinase insert domain receptor
KIF1B kinesin family member 1B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAPTM5 lysosomal protein transmembrane 5
LMO4 LIM domain only 4
MAPT microtubule-associated protein tau
MIR181A1 microRNA 181a-1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
NGFR nerve growth factor receptor
NTF3 neurotrophin 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PDPN podoplanin
PHOX2B paired-like homeobox 2b
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PROX1 prospero homeobox 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SSTR2 somatostatin receptor 2
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
YEATS4 YEATS domain containing 4
ZAR1 zygote arrest 1