neuromuscular junction Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. (Gene Ontology, GO_0031594)
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Genes

47 proteins localized to the neuromuscular junction cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor 0.663342
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.663342
CDK5 cyclin-dependent kinase 5 0.237908
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.237908
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.237908
F2R coagulation factor II (thrombin) receptor 0.237908
MUSK muscle, skeletal, receptor tyrosine kinase 0.237908
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.237908
PSEN1 presenilin 1 0.098109
CAV3 caveolin 3 0.098109
TBC1D24 TBC1 domain family, member 24 0.098109
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.098109
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.098109
ACHE acetylcholinesterase (Yt blood group) 0.098109
PSEN2 presenilin 2 0.098109
LRP4 low density lipoprotein receptor-related protein 4 0.098109
COL4A5 collagen, type IV, alpha 5 0.03318
UNC13B unc-13 homolog B (C. elegans) 0.03318
UTRN utrophin 0.03318
MYH9 myosin, heavy chain 9, non-muscle 0.03318
SYNGR3 synaptogyrin 3 0.03318
RAPSN receptor-associated protein of the synapse 0.03318
EFNA2 ephrin-A2 0.03318
DOK7 docking protein 7 0.03318
UNC13A unc-13 homolog A (C. elegans) 0.03318
MYH10 myosin, heavy chain 10, non-muscle 0.03318
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 0.03318
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 0.03318
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.03318
EPHA4 EPH receptor A4 0.03318
PDZRN3 PDZ domain containing ring finger 3 0.03318
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.03318
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.03318
SNTA1 syntrophin, alpha 1 0.03318
SV2A synaptic vesicle glycoprotein 2A 0.03318
HDAC4 histone deacetylase 4 0.03318
SYNC syncoilin, intermediate filament protein 0.03318
APP amyloid beta (A4) precursor protein 0.03318
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.03318
DES desmin 0.03318
DLG1 discs, large homolog 1 (Drosophila) 0.03318
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.03318
CIB2 calcium and integrin binding family member 2 0.03318
ITGA7 integrin, alpha 7 0.03318
NEFM neurofilament, medium polypeptide 0.03318
NRG1 neuregulin 1 0.03318
EPHA7 EPH receptor A7 0.03318