neuromuscular junction Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. (Gene Ontology, GO_0031594)
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Genes

296 proteins co-occuring with the neuromuscular junction cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MUSK muscle, skeletal, receptor tyrosine kinase 3.42795
ACHE acetylcholinesterase (Yt blood group) 3.10024
RAPSN receptor-associated protein of the synapse 2.74417
BCHE butyrylcholinesterase 2.59881
DOK7 docking protein 7 2.15517
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.9216
UTRN utrophin 1.84634
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 1.83679
DMD dystrophin 1.78583
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 1.776
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 1.776
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.62
CALCA calcitonin-related polypeptide alpha 1.48701
LRP4 low density lipoprotein receptor-related protein 4 1.44573
CHRND cholinergic receptor, nicotinic, delta (muscle) 1.35649
CHAT choline O-acetyltransferase 1.34283
GFPT1 glutamine--fructose-6-phosphate transaminase 1 1.32762
SMN2 survival of motor neuron 2, centromeric 1.27983
AGRN agrin 1.2476
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.23088
SMN1 survival of motor neuron 1, telomeric 1.2086
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 1.19057
LAMB2 laminin, beta 2 (laminin S) 1.14648
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 1.13165
PRIMA1 proline rich membrane anchor 1 1.03078
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 1.02879
NRG1 neuregulin 1 1.02281
MGAM maltase-glucoamylase 1.01238
NTF4 neurotrophin 4 1.0109
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.00399
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.996123
SYP synaptophysin 0.994162
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.983419
GDNF glial cell derived neurotrophic factor 0.974198
CD44 CD44 molecule (Indian blood group) 0.966956
BDNF brain-derived neurotrophic factor 0.95305
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.949713
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.937377
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.879633
SYT1 synaptotagmin I 0.874107
C1ORF123 chromosome 1 open reading frame 123 0.86077
CNTF ciliary neurotrophic factor 0.852961
NMT1 N-myristoyltransferase 1 0.831384
CST7 cystatin F (leukocystatin) 0.814864
MYOG myogenin (myogenic factor 4) 0.813028
DMPK dystrophia myotonica-protein kinase 0.812111
TAC1 tachykinin, precursor 1 0.802938
RAB3A RAB3A, member RAS oncogene family 0.798353
NRG2 neuregulin 2 0.784156
ERBB3 erb-b2 receptor tyrosine kinase 3 0.779126
SNTA1 syntrophin, alpha 1 0.755437
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.75453
NTF3 neurotrophin 3 0.754076
MYF6 myogenic factor 6 (herculin) 0.732422
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.726152
NCAM1 neural cell adhesion molecule 1 0.723919
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.718125
MYOD1 myogenic differentiation 1 0.712795
KLHL8 kelch-like family member 8 0.708366
NALCN sodium leak channel, non selective 0.707482
SYT2 synaptotagmin II 0.70439
IGHMBP2 immunoglobulin mu binding protein 2 0.701744
TNC tenascin C 0.692955
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.692516
UBE4B ubiquitination factor E4B 0.689888
MYBPC1 myosin binding protein C, slow type 0.684644
BSN bassoon presynaptic cytomatrix protein 0.682463
NPS neuropeptide S 0.672026
TMPO thymopoietin 0.665529
SCN3A sodium channel, voltage gated, type III alpha subunit 0.664664
SDC2 syndecan 2 0.660776
NGF nerve growth factor (beta polypeptide) 0.659482
NGFR nerve growth factor receptor 0.640145
PTN pleiotrophin 0.625632
PLA2G1B phospholipase A2, group IB (pancreas) 0.620954
SH3GL2 SH3-domain GRB2-like 2 0.615861
CAV3 caveolin 3 0.609086
ECEL1 endothelin converting enzyme-like 1 0.60444
CDK5 cyclin-dependent kinase 5 0.604017
OARD1 O-acyl-ADP-ribose deacylase 1 0.601909
DNM2 dynamin 2 0.587199
IGF1 insulin-like growth factor 1 (somatomedin C) 0.586361
NSF N-ethylmaleimide-sensitive factor 0.586361
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.586361
SYN1 synapsin I 0.585523
SLITRK1 SLIT and NTRK-like family, member 1 0.580922
PLEC plectin 0.576329
APP amyloid beta (A4) precursor protein 0.572994
DACH2 dachshund family transcription factor 2 0.563847
NBEA neurobeachin 0.562602
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.561358
MYNN myoneurin 0.560943
NGEF neuronal guanine nucleotide exchange factor 0.557629
ERBB4 erb-b2 receptor tyrosine kinase 4 0.552664
GAP43 growth associated protein 43 0.546885
CORO6 coronin 6 0.544411
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.543587
ZBTB42 zinc finger and BTB domain containing 42 0.539883
ERBB2 erb-b2 receptor tyrosine kinase 2 0.513677
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.510418
PLS3 plastin 3 0.503099
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.502693
POMT1 protein-O-mannosyltransferase 1 0.50107
VIP vasoactive intestinal peptide 0.497015
MAP1B microtubule-associated protein 1B 0.496205
AMPH amphiphysin 0.495395
LGALS4 lectin, galactoside-binding, soluble, 4 0.495395
MNX1 motor neuron and pancreas homeobox 1 0.49499
LAMA2 laminin, alpha 2 0.493371
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.488519
ANK2 ankyrin 2, neuronal 0.488115
GAL galanin/GMAP prepropeptide 0.484079
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.470005
PARK2 parkin RBR E3 ubiquitin protein ligase 0.468802
FUS FUS RNA binding protein 0.4676
ANK1 ankyrin 1, erythrocytic 0.465198
NFASC neurofascin 0.463198
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.454418
TYRO3 TYRO3 protein tyrosine kinase 0.447259
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.446069
SHPK sedoheptulokinase 0.445672
DLG1 discs, large homolog 1 (Drosophila) 0.442104
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 0.433012
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.426711
SOD2 superoxide dismutase 2, mitochondrial 0.425924
SSPN sarcospan 0.42396
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.423174
EPHB3 EPH receptor B3 0.423174
WNT9A wingless-type MMTV integration site family, member 9A 0.421604
ADCY2 adenylate cyclase 2 (brain) 0.42082
CNTN1 contactin 1 0.418077
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.416902
SPTB spectrin, beta, erythrocytic 0.41143
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.410649
DNAH8 dynein, axonemal, heavy chain 8 0.410259
FKTN fukutin 0.408309
MYF5 myogenic factor 5 0.403637
GPHN gephyrin 0.40247
PDZRN3 PDZ domain containing ring finger 3 0.401304
UNC13B unc-13 homolog B (C. elegans) 0.399363
EPHA4 EPH receptor A4 0.392775
DLG3 discs, large homolog 3 (Drosophila) 0.391228
FGF2 fibroblast growth factor 2 (basic) 0.389296
SPAST spastin 0.386208
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.381584
SYNE1 spectrin repeat containing, nuclear envelope 1 0.376202
DLG2 discs, large homolog 2 (Drosophila) 0.375434
PTPRB protein tyrosine phosphatase, receptor type, B 0.371216
NPY neuropeptide Y 0.370833
DPYSL5 dihydropyrimidinase-like 5 0.369301
EMC7 ER membrane protein complex subunit 7 0.367771
ADAMTSL3 ADAMTS-like 3 0.366241
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.363949
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.363567
NLGN2 neuroligin 2 0.362804
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.361277
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.360515
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.359752
ADAM19 ADAM metallopeptidase domain 19 0.358609
ADA adenosine deaminase 0.357086
CAMP cathelicidin antimicrobial peptide 0.354042
TARDBP TAR DNA binding protein 0.353282
GARS glycyl-tRNA synthetase 0.351002
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.350622
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.350622
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.350243
GLB1 galactosidase, beta 1 0.347587
NAV1 neuron navigator 1 0.346829
GFAP glial fibrillary acidic protein 0.345692
ITGA7 integrin, alpha 7 0.345314
RAP2B RAP2B, member of RAS oncogene family 0.345314
EMX1 empty spiracles homeobox 1 0.343421
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.340773
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.340773
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.340017
POMC proopiomelanocortin 0.340017
SAR1A secretion associated, Ras related GTPase 1A 0.338506
ARF3 ADP-ribosylation factor 3 0.338128
RAB1B RAB1B, member RAS oncogene family 0.335487
HDAC4 histone deacetylase 4 0.326078
SNTG2 syntrophin, gamma 2 0.324576
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.320077
TSN translin 0.31783
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.317082
HMOX2 heme oxygenase 2 0.317082
FBXO45 F-box protein 45 0.315212
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.313718
ORC3 origin recognition complex, subunit 3 0.312971
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.310358
INS insulin 0.308122
ENO3 enolase 3 (beta, muscle) 0.307749
PNPLA6 patatin-like phospholipase domain containing 6 0.307377
UTS2B urotensin 2B 0.307004
MEOX1 mesenchyme homeobox 1 0.298455
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.294378
MTM1 myotubularin 1 0.292897
RET ret proto-oncogene 0.292157
FMR1 fragile X mental retardation 1 0.289938
SNAP23 synaptosomal-associated protein, 23kDa 0.289569
EGFLAM EGF-like, fibronectin type III and laminin G domains 0.289199
FOXP3 forkhead box P3 0.288091
MMP3 matrix metallopeptidase 3 0.286983
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.285138
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.284769
VCL vinculin 0.284401
ADAMTSL1 ADAMTS-like 1 0.284032
NLGN1 neuroligin 1 0.280349
MED18 mediator complex subunit 18 0.275569
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 0.268603
CSAD cysteine sulfinic acid decarboxylase 0.267139
COL19A1 collagen, type XIX, alpha 1 0.266042
NES nestin 0.260566
GLRB glycine receptor, beta 0.259837
NKX6-2 NK6 homeobox 2 0.259473
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.258745
DES desmin 0.258016
NRG4 neuregulin 4 0.252564
FOS FBJ murine osteosarcoma viral oncogene homolog 0.246046
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.244962
NTS neurotensin 0.244962
GUCY2C guanylate cyclase 2C 0.244601
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.242437
PRNP prion protein 0.240636
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.239557
NPR1 natriuretic peptide receptor 1 0.237042
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 0.235966
WNT3A wingless-type MMTV integration site family, member 3A 0.233101
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.232386
CADM2 cell adhesion molecule 2 0.230601
ALG10 ALG10, alpha-1,2-glucosyltransferase 0.230245
FST follistatin 0.226686
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.225976
CDC42 cell division cycle 42 0.22385
RTN4 reticulon 4 0.222083
GPR162 G protein-coupled receptor 162 0.219969
TBC1D15 TBC1 domain family, member 15 0.218914
AQP4 aquaporin 4 0.218563
UNC13A unc-13 homolog A (C. elegans) 0.218563
SLC10A4 solute carrier family 10, member 4 0.218212
SOD1 superoxide dismutase 1, soluble 0.217861
AR androgen receptor 0.215761
TTN titin 0.214366
SPG11 spastic paraplegia 11 (autosomal recessive) 0.211933
COL13A1 collagen, type XIII, alpha 1 0.211587
GMFG glia maturation factor, gamma 0.210549
PLA2G2D phospholipase A2, group IID 0.208481
TNIP1 TNFAIP3 interacting protein 1 0.207108
FGF22 fibroblast growth factor 22 0.203361
IGHV3-30 immunoglobulin heavy variable 3-30 0.201335
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.196999
FGF5 fibroblast growth factor 5 0.196669
CD59 CD59 molecule, complement regulatory protein 0.195025
RAB3C RAB3C, member RAS oncogene family 0.193719
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.191135
AKAP1 A kinase (PRKA) anchor protein 1 0.190495
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.190175
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 0.18859
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.18796
JUN jun proto-oncogene 0.187333
MIR133B microRNA 133b 0.18702
STX1B syntaxin 1B 0.18516
SPAG9 sperm associated antigen 9 0.183328
LAMA5 laminin, alpha 5 0.181823
F2R coagulation factor II (thrombin) receptor 0.178877
NLGN4X neuroligin 4, X-linked 0.178011
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.174635
CRCP CGRP receptor component 0.174361
ONECUT3 one cut homeobox 3 0.173003
NOS1 nitric oxide synthase 1 (neuronal) 0.172735
DRP2 dystrophin related protein 2 0.172201
FYN FYN proto-oncogene, Src family tyrosine kinase 0.172201
NRXN1 neurexin 1 0.17141
STAU1 staufen double-stranded RNA binding protein 1 0.16935
MYO5A myosin VA (heavy chain 12, myoxin) 0.168847
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.168598
CLASP2 cytoplasmic linker associated protein 2 0.168598
CADM1 cell adhesion molecule 1 0.167366
COL25A1 collagen, type XXV, alpha 1 0.166643
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.165932
PYGB phosphorylase, glycogen; brain 0.165463
PYGL phosphorylase, glycogen, liver 0.165231
TH tyrosine hydroxylase 0.164315
PYGM phosphorylase, glycogen, muscle 0.164089
BACE1 beta-site APP-cleaving enzyme 1 0.163641
GAS7 growth arrest-specific 7 0.162546
CLIP3 CAP-GLY domain containing linker protein 3 0.162117
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.161693
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.160658
LMNB1 lamin B1 0.160456
FN1 fibronectin 1 0.159658
HSPA4 heat shock 70kDa protein 4 0.158692
EMB embigin 0.158315
SPATA13 spermatogenesis associated 13 0.158129
CADM4 cell adhesion molecule 4 0.15776
EGR3 early growth response 3 0.157578
EIF4E eukaryotic translation initiation factor 4E 0.156863