neuropil Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description In neuroanatomy, a neuropil is a region between neuronal cell bodies in the gray matter of the brain and blood-brain barrier (i.e. the central nervous system). It consists of a dense tangle of axon terminals, dendrites and glial cell processes. It is where synaptic connections are formed between branches of axons and dendrites. White matter, which is mostly composed of axons and glial cells, is generally not considered to be a part of the neuropil. (BRENDA Tissue and Enzyme Source Ontology, BTO_0005268)
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Genes

358 proteins co-occuring with the tissue neuropil in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
SYP synaptophysin 2.15437
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 2.11233
PVALB parvalbumin 2.0744
CALB1 calbindin 1, 28kDa 2.053
ACHE acetylcholinesterase (Yt blood group) 1.93468
MAPT microtubule-associated protein tau 1.90758
CHAT choline O-acetyltransferase 1.75624
CALB2 calbindin 2 1.74176
NPS neuropeptide S 1.71738
LGALS4 lectin, galactoside-binding, soluble, 4 1.63956
PRNP prion protein 1.60415
TH tyrosine hydroxylase 1.58732
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.58535
TAC1 tachykinin, precursor 1 1.49632
MAP2 microtubule-associated protein 2 1.39881
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.35904
TECTA tectorin alpha 1.33817
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.32055
CA4 carbonic anhydrase IV 1.29579
GFAP glial fibrillary acidic protein 1.2904
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.27157
HTT huntingtin 1.25012
NTS neurotensin 1.2452
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.20912
PHF1 PHD finger protein 1 1.206
APP amyloid beta (A4) precursor protein 1.18334
PSEN1 presenilin 1 1.17757
ENO2 enolase 2 (gamma, neuronal) 1.15761
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 1.15451
RICTOR RPTOR independent companion of MTOR, complex 2 1.15318
TNR tenascin R 1.14077
CCK cholecystokinin 1.12748
SST somatostatin 1.11022
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.09253
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.08104
NPY neuropeptide Y 1.05061
APOE apolipoprotein E 1.04708
BCHE butyrylcholinesterase 1.03346
GRIK1 glutamate receptor, ionotropic, kainate 1 1.01331
SYN1 synapsin I 1.00414
MAP4 microtubule-associated protein 4 0.9889
GRM1 glutamate receptor, metabotropic 1 0.980217
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.980217
AQP4 aquaporin 4 0.977616
GAP43 growth associated protein 43 0.953409
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.941785
TOR1B torsin family 1, member B (torsin B) 0.931908
PPY pancreatic polypeptide 0.926336
RELN reelin 0.919061
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.890101
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.883744
DSCAM Down syndrome cell adhesion molecule 0.879935
SCGN secretagogin, EF-hand calcium binding protein 0.871905
GRM5 glutamate receptor, metabotropic 5 0.867263
SNCAIP synuclein, alpha interacting protein 0.86347
NGF nerve growth factor (beta polypeptide) 0.852527
NCAN neurocan 0.849165
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.828616
LSAMP limbic system-associated membrane protein 0.816904
SDF4 stromal cell derived factor 4 0.78231
NCAM1 neural cell adhesion molecule 1 0.774419
BCAN brevican 0.774004
GLUL glutamate-ammonia ligase 0.77027
GRM2 glutamate receptor, metabotropic 2 0.766125
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.759086
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.751231
BDNF brain-derived neurotrophic factor 0.744214
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.733089
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.722809
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.719934
RD3 retinal degeneration 3 0.717472
FAIM2 Fas apoptotic inhibitory molecule 2 0.711319
CALCA calcitonin-related polypeptide alpha 0.685551
CAPN7 calpain 7 0.682695
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.68188
ALB albumin 0.679433
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.679025
BSN bassoon presynaptic cytomatrix protein 0.671285
NGFR nerve growth factor receptor 0.668029
TMCC2 transmembrane and coiled-coil domain family 2 0.663555
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.655024
CA1 carbonic anhydrase I 0.65056
ABAT 4-aminobutyrate aminotransferase 0.648127
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.637999
TIMELESS timeless circadian clock 0.633144
UBQLN1 ubiquilin 1 0.627485
PDYN prodynorphin 0.625869
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.625061
DBN1 drebrin 1 0.622639
RAB3A RAB3A, member RAS oncogene family 0.616586
SV2A synaptic vesicle glycoprotein 2A 0.614571
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.60893
DRP2 dystrophin related protein 2 0.602088
GLS glutaminase 0.600479
CA13 carbonic anhydrase XIII 0.595656
B3GAT1 beta-1,3-glucuronyltransferase 1 0.593649
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 0.59124
BOD1 biorientation of chromosomes in cell division 1 0.578016
TOR1A torsin family 1, member A (torsin A) 0.578016
OR6Y1 olfactory receptor, family 6, subfamily Y, member 1 0.575216
MBP myelin basic protein 0.573217
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.573217
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.573217
GAST gastrin 0.572418
EPHB3 EPH receptor B3 0.572018
ACPP acid phosphatase, prostate 0.571219
RCAN3 RCAN family member 3 0.57082
PREPL prolyl endopeptidase-like 0.570021
DMWD dystrophia myotonica, WD repeat containing 0.565631
KIRREL3 kin of IRRE like 3 (Drosophila) 0.560449
EPHA4 EPH receptor A4 0.559254
SOD2 superoxide dismutase 2, mitochondrial 0.558856
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.556467
GLS2 glutaminase 2 (liver, mitochondrial) 0.545342
BRSK2 BR serine/threonine kinase 2 0.538209
CHGA chromogranin A 0.537416
CRH corticotropin releasing hormone 0.537021
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.531879
TTBK1 tau tubulin kinase 1 0.530693
XPO6 exportin 6 0.529113
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.525955
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.525166
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.524377
SNTG2 syntrophin, gamma 2 0.523588
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.519647
IGSF8 immunoglobulin superfamily, member 8 0.518072
ALPP alkaline phosphatase, placental 0.51571
NRCAM neuronal cell adhesion molecule 0.511384
APOD apolipoprotein D 0.510599
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.509027
UNC13C unc-13 homolog C (C. elegans) 0.50275
CDH8 cadherin 8, type 2 0.498048
KSR2 kinase suppressor of ras 2 0.497657
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.497266
GAL galanin/GMAP prepropeptide 0.496874
TUBA1A tubulin, alpha 1a 0.493354
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.492182
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.488276
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.482038
AIF1 allograft inflammatory factor 1 0.477756
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.471151
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.469987
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.468436
CMC2 C-x(9)-C motif containing 2 0.46766
DPYSL2 dihydropyrimidinase-like 2 0.465335
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.464948
MNS1 meiosis-specific nuclear structural 1 0.461078
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.459918
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.459145
TMEM106B transmembrane protein 106B 0.458759
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.454898
NTF3 neurotrophin 3 0.451428
CNR1 cannabinoid receptor 1 (brain) 0.449886
TARDBP TAR DNA binding protein 0.449501
ICAM5 intercellular adhesion molecule 5, telencephalin 0.448731
GPHN gephyrin 0.447576
ATRN attractin 0.446422
POMC proopiomelanocortin 0.441426
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.441042
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.431077
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.431077
NOS1 nitric oxide synthase 1 (neuronal) 0.42993
KCTD12 potassium channel tetramerization domain containing 12 0.42993
CPLX2 complexin 2 0.429547
ULK2 unc-51 like autophagy activating kinase 2 0.427254
ANAPC4 anaphase promoting complex subunit 4 0.423436
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.422292
DPYSL3 dihydropyrimidinase-like 3 0.420766
CAPN15 calpain 15 0.420766
CRYAB crystallin, alpha B 0.412011
GSAP gamma-secretase activating protein 0.411251
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.407832
DMD dystrophin 0.404797
NOTCH1 notch 1 0.402523
NT5E 5'-nucleotidase, ecto (CD73) 0.398735
GDNF glial cell derived neurotrophic factor 0.397979
LMTK2 lemur tyrosine kinase 2 0.396844
ELSPBP1 epididymal sperm binding protein 1 0.394197
DNAH8 dynein, axonemal, heavy chain 8 0.393819
FTL ferritin, light polypeptide 0.391553
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.391553
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.390799
DPYSL5 dihydropyrimidinase-like 5 0.390044
CLSTN1 calsyntenin 1 0.387781
RYK receptor-like tyrosine kinase 0.384013
MGAT4C MGAT4 family, member C 0.378748
EWSR1 EWS RNA-binding protein 1 0.375743
VCAN versican 0.375743
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.374618
MAG myelin associated glycoprotein 0.371994
SDC2 syndecan 2 0.368998
AGO1 argonaute RISC catalytic component 1 0.368998
CLU clusterin 0.367129
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.367129
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 0.362273
PHYH phytanoyl-CoA 2-hydroxylase 0.362273
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.360409
SEPT5 septin 5 0.35743
GJA1 gap junction protein, alpha 1, 43kDa 0.356314
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.354084
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.351856
PNMT phenylethanolamine N-methyltransferase 0.350372
KALRN kalirin, RhoGEF kinase 0.34963
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.348148
OPRM1 opioid receptor, mu 1 0.347778
DNASE2 deoxyribonuclease II, lysosomal 0.346298
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.345188
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.34371
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.342602
FTH1 ferritin, heavy polypeptide 1 0.340019
CDH10 cadherin 10, type 2 (T2-cadherin) 0.33965
ADRA2A adrenoceptor alpha 2A 0.338545
TAOK1 TAO kinase 1 0.338545
SNCB synuclein, beta 0.334498
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.332294
EPHB2 EPH receptor B2 0.331927
IFNA8 interferon, alpha 8 0.330094
SNAP25 synaptosomal-associated protein, 25kDa 0.329727
FBXO44 F-box protein 44 0.328994
UBB ubiquitin B 0.32753
CST3 cystatin C 0.320956
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.319134
EPHA3 EPH receptor A3 0.316951
CD99 CD99 molecule 0.316588
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.316224
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.315498
PENK proenkephalin 0.315498
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.31332
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.311507
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.310059
PDE10A phosphodiesterase 10A 0.309335
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 0.309154
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.306444
PSEN2 presenilin 2 0.303559
NLRP12 NLR family, pyrin domain containing 12 0.303198
SCN10A sodium channel, voltage gated, type X alpha subunit 0.302118
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.301398
VIP vasoactive intestinal peptide 0.300679
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.300679
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.300679
FLNB filamin B, beta 0.299242
PICK1 protein interacting with PRKCA 1 0.299242
NPTN neuroplastin 0.297447
NTNG2 netrin G2 0.296372
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.289582
EMX1 empty spiracles homeobox 1 0.289226
SNAP23 synaptosomal-associated protein, 23kDa 0.28887
ACTL6A actin-like 6A 0.28887
GFRA1 GDNF family receptor alpha 1 0.287447
CNTN2 contactin 2 (axonal) 0.287447
ATG4B autophagy related 4B, cysteine peptidase 0.287447
EPS15 epidermal growth factor receptor pathway substrate 15 0.285316
HPCAL1 hippocalcin-like 1 0.283545
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.281423
GJD2 gap junction protein, delta 2, 36kDa 0.281423
MGLL monoglyceride lipase 0.280364
GPM6A glycoprotein M6A 0.279659
RHO rhodopsin 0.277549
FKTN fukutin 0.275444
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.274045
CEND1 cell cycle exit and neuronal differentiation 1 0.273696
ALPPL2 alkaline phosphatase, placental-like 2 0.273346
ALPL alkaline phosphatase, liver/bone/kidney 0.272649
S100B S100 calcium binding protein B 0.2723
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 0.271604
TNC tenascin C 0.271604
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.267791
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.266757
MEA1 male-enhanced antigen 1 0.266413
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.266413
CELF4 CUGBP, Elav-like family member 4 0.265038
NTF4 neurotrophin 4 0.262304
GRIK4 glutamate receptor, ionotropic, kainate 4 0.261964
CHMP2B charged multivesicular body protein 2B 0.261284
MAP1B microtubule-associated protein 1B 0.260945
CA2 carbonic anhydrase II 0.260606
DAOA D-amino acid oxidase activator 0.260267
PNMA2 paraneoplastic Ma antigen 2 0.257907
RTN3 reticulon 3 0.257237
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.256902
CLEC2B C-type lectin domain family 2, member B 0.256902
ADCY2 adenylate cyclase 2 (brain) 0.256234
ATXN2 ataxin 2 0.256067
FGF2 fibroblast growth factor 2 (basic) 0.251606
UTS2 urotensin 2 0.250627
PINK1 PTEN induced putative kinase 1 0.248361
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.248361
TDO2 tryptophan 2,3-dioxygenase 0.242828
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.242672
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.242054
SIM2 single-minded family bHLH transcription factor 2 0.241746
FLOT1 flotillin 1 0.241746
CALY calcyon neuron-specific vesicular protein 0.241438
DYNLL1 dynein, light chain, LC8-type 1 0.241285
SESN2 sestrin 2 0.239913
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.238108
FN1 fibronectin 1 0.23781
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.234878
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.23459
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.233731
BSX brain-specific homeobox 0.233731
GYG1 glycogenin 1 0.2319
NPAT nuclear protein, ataxia-telangiectasia locus 0.230656
GPR50 G protein-coupled receptor 50 0.229299
FRY furry homolog (Drosophila) 0.229032
BAALC brain and acute leukemia, cytoplasmic 0.228764
AMPH amphiphysin 0.226926
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.226539
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.224893
ELN elastin 0.224398
CDK5 cyclin-dependent kinase 5 0.222699
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 0.222699
NEFH neurofilament, heavy polypeptide 0.22246
SYNPR synaptoporin 0.22246
ULK1 unc-51 like autophagy activating kinase 1 0.221291
LAMA1 laminin, alpha 1 0.220831
FOS FBJ murine osteosarcoma viral oncogene homolog 0.220831
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.219485
MGAM maltase-glucoamylase 0.219047
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.219047
SRM spermidine synthase 0.216325
DLG1 discs, large homolog 1 (Drosophila) 0.215341
DGCR8 DGCR8 microprocessor complex subunit 0.214294
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.213112
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.212848
GALP galanin-like peptide 0.212761
LIMK1 LIM domain kinase 1 0.20424
CAV2 caveolin 2 0.203474
PRDM1 PR domain containing 1, with ZNF domain 0.203179
DROSHA drosha, ribonuclease type III 0.203138
CRYGD crystallin, gamma D 0.202663
WAPAL wings apart-like homolog (Drosophila) 0.199595
PAM peptidylglycine alpha-amidating monooxygenase 0.198684
MYO5A myosin VA (heavy chain 12, myoxin) 0.197863
CD27 CD27 molecule 0.197309
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.197309
PRODH proline dehydrogenase (oxidase) 1 0.197289
NUMB numb homolog (Drosophila) 0.196983
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.196885
GNLY granulysin 0.196786
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.19651
SYT1 synaptotagmin I 0.19643
L1CAM L1 cell adhesion molecule 0.195918
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.195886
HDAC3 histone deacetylase 3 0.195854
CAV3 caveolin 3 0.195373
CYCS cytochrome c, somatic 0.19534
AGO2 argonaute RISC catalytic component 2 0.194764
CLOCK clock circadian regulator 0.194554
HDAC2 histone deacetylase 2 0.194441
KMT2A lysine (K)-specific methyltransferase 2A 0.194274
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.193835
KAT5 K(lysine) acetyltransferase 5 0.192575
GUCY2C guanylate cyclase 2C 0.19256
NPR1 natriuretic peptide receptor 1 0.192465
DICER1 dicer 1, ribonuclease type III 0.192009
MX1 MX dynamin-like GTPase 1 0.189829
MECOM MDS1 and EVI1 complex locus 0.189808