nf1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description neurofibromin 1|This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4763)
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Genes

66 genes co-occuring with the biological term nf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2L1 BCL2-like 1
BRCA1 breast cancer 1, early onset
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN2B-AS1 CDKN2B antisense RNA 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
DDR2 discoidin domain receptor tyrosine kinase 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EGFR epidermal growth factor receptor
ESRRA estrogen-related receptor alpha
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GDNF glial cell derived neurotrophic factor
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSF1 heat shock transcription factor 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1R insulin-like growth factor 1 receptor
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
LRPPRC leucine-rich pentatricopeptide repeat containing
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MIR10B microRNA 10b
MIR193B microRNA 193b
MIR370 microRNA 370
MOG myelin oligodendrocyte glycoprotein
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NF1 neurofibromin 1
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NKX2-5 NK2 homeobox 5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGR progesterone receptor
POU2F1 POU class 2 homeobox 1
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PTBP2 polypyrimidine tract binding protein 2
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RET ret proto-oncogene
RNF135 ring finger protein 135
S100B S100 calcium binding protein B
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPRED1 sprouty-related, EVH1 domain containing 1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TERT telomerase reverse transcriptase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
YBX1 Y box binding protein 1