nfatc1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1|The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 4772)
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Genes

40 genes co-occuring with the biological term nfatc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
CALCR calcitonin receptor
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CD28 CD28 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EP300 E1A binding protein p300
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
ICAM1 intercellular adhesion molecule 1
IFNB1 interferon, beta 1, fibroblast
IL1B interleukin 1, beta
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KDM8 lysine (K)-specific demethylase 8
LACRT lacritin
MIR145 microRNA 145
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
OSCAR osteoclast associated, immunoglobulin-like receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RCAN1 regulator of calcineurin 1
SP7 Sp7 transcription factor
SPI1 Spi-1 proto-oncogene
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
VEGFA vascular endothelial growth factor A