nfatc2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2|This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 4773)
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Genes

24 genes co-occuring with the biological term nfatc2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD40LG CD40 ligand
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
EGR1 early growth response 1
FAM3D family with sequence similarity 3, member D
HSF1 heat shock transcription factor 1
IL2 interleukin 2
IL21 interleukin 21
IL6 interleukin 6
JUN jun proto-oncogene
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MIR184 microRNA 184
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
POLE polymerase (DNA directed), epsilon, catalytic subunit
PRKCZ protein kinase C, zeta
SCP2 sterol carrier protein 2
TNF tumor necrosis factor
TRA T cell receptor alpha locus
USP22 ubiquitin specific peptidase 22
WNT5A wingless-type MMTV integration site family, member 5A