nfkb1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description nuclear factor of kappa light polypeptide gene enhancer in B-cells 1|This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 4790)
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Genes

28 genes co-occuring with the biological term nfkb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
CYP3A cytochrome P450, family 3, subfamily A
GADD45A growth arrest and DNA-damage-inducible, alpha
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IRAK3 interleukin-1 receptor-associated kinase 3
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
MAPK8 mitogen-activated protein kinase 8
MIR9-3 microRNA 9-3
NCF2 neutrophil cytosolic factor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
PLAUR plasminogen activator, urokinase receptor
REL v-rel avian reticuloendotheliosis viral oncogene homolog
REST RE1-silencing transcription factor
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SOD1 superoxide dismutase 1, soluble
STAT1 signal transducer and activator of transcription 1, 91kDa
TAL1 T-cell acute lymphocytic leukemia 1
TNF tumor necrosis factor
TNIP1 TNFAIP3 interacting protein 1