nhej Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. (Gene Ontology, GO_0006303)
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Genes

38 genes co-occuring with the biological term nhej in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLF aprataxin and PNKP like factor
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BLM Bloom syndrome, RecQ helicase-like
C9ORF142 chromosome 9 open reading frame 142
CHEK1 checkpoint kinase 1
DCLRE1C DNA cross-link repair 1C
EGFR epidermal growth factor receptor
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
IL24 interleukin 24
LIG4 ligase IV, DNA, ATP-dependent
MAP3K3 mitogen-activated protein kinase kinase kinase 3
NBN nibrin
NHEJ1 nonhomologous end-joining factor 1
PARP1 poly (ADP-ribose) polymerase 1
PIDD1 p53-induced death domain protein 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAD18 RAD18 E3 ubiquitin protein ligase
RBBP8 retinoblastoma binding protein 8
RECQL4 RecQ protein-like 4
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
SP1 Sp1 transcription factor
STK11 serine/threonine kinase 11
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6